PRESBYTERIAN MEDICAL CENTER

CLAY AND WEBSTER STREETS
SAN FRANCISCO 15, CALIFORNIA

December 1, 1960

Professor Joshua Lederberg,

Stanford University School of Medicine,
300 Pasteur Drive,

Palo Alto, California.

Dear Professor Lederberg:

Recently Dr. Shumway suggested that you might be interested
in our early studies in isoskingrafting. An important observation
described but not stressed in the reprint is the fate of my own two
sets of donor grafts (E.H. page 11). The first set applied April 3 took
perfectly and spread normally. A second set applied April 25 at a time
when the first set was still in blooming condition (though about to be-
gin to disappear on May 2) floated off in a sea of wound fluid—obviously
already quite distasteful to the host. A second set of srafts from
another donor applied on April 2 took but they, too, began to disappear
about May 2. Meanwhile, e third donor supplied a set of grafts on April
1@ which took and continued to tarive until May 14 even though the grefts
from the first and second donors had begun to disapoesr on May 2, indica—
ting a highly specific reaction of the donee to each set of donor grafts
(anticipating Medawar by many years!)

The second reprint is sent as I thought you would be amused by
Dr. Halsted's allusion in 1914 (page 8) to what is happening in the outer
space-world about to be invaded by our astronauts!

With kindest regards,

Sincerely yours,

ech, Mek

Emile Holman, M.D.
EH—eh