THE JOHNS HOPKINS UNIVERSITY SCHOOL OF HYGIENE AND PUBLIC HEALTH 615 NORTH WOLFE STREET BALTIMORE - 5, MARYLAND DEPARTMENT OF BIOCHEMISTRY May 19, 1958 Dr. Joshua Lederberg Department of Medical Genetics University of Wisconsin Madison, Wisconsin Dear Joshua: The organism WH-8-Sm unfortunately does not yield its DNA readily in my hands. I've had no success extracting anything with the phenol method which will transform, but there doesn't seem to be much 260 material extracted either. I'11 give it one more trial using a method which ruptures the cells and then extract with the Sevag procedure. Enclosed you will find my curriculum vitae. With best regards, Sincerely, of Sol H. Goodgal SHG: csb