SEP 24 1962

THE LILLY RESEARCH LABORATORIES

EL! LILLY AND COMPANY
INDIANAPOLIS 6G, IND.,U. S.A.

September 18, 1962

Dr. Joshua Lederberg, Chairman
Department of Genetics

School of Medicine

Stanford University

Stanford, California

Dear Dr. Lederberg:

Thank you for your letter of September 14 with welcome comments
on our ribotide amidate work.

Concerning the thymidylic derivative, I will have to do some
work on the cold synthesis. I hope we will be able to do the
c14 or tritium label later here or at S.I.M.B.

I have given some thought recently to extending this work to

the 5 FU series as this would add to the picture and be, chemi-
cally, actually easier in the last step of the synthesis. Ig,
will communicate on this with Dr. Aronow and, if agreeable, wiht cau)
I will contact Dr. Heidelberger at Wisconsin. He has both starting
materials and test organisms on hand. This would reduce my work
from years to weeks.

I am anxious to pursue this work but find it more time consuming
than I had thought to get the laboratory going.

I am sorry to hear that you will be unable tocome here in October,
but we will try to do the best we can in spite of this handicap.

Sincerely yours,
, a en

KO he . <..

Koert Gerzon
Organic Chemical Division

ba

-

xin
Oe

749 J

mS