SEP 10 1962
THE LILLY RESEARCH LABORATORIES

ELt LILLY AND COMPANY
INDIANAPOLIS G,IND.,U. S.A.

September 4, 1962

Dr. Joshue Lederberg, Chairman
Department of Genetics

School of Medicine

Stanford University

Stanford, California

Dear Dr. Lederberg:

You have probably heard at the institute of the encouraging
results which Dr. Aronow has obtained with our 6-MP ribotide
amidate in 6-MP resistant cells. Although I am aware tnat~much
éonfirmation and rechecking is in order, I feel we should check
this lead in other ways, too.

Ma 249)

To this end, I hope, as soon as feasible, to prepare again the
corresponding thymidylic acid amidate, this time in the form of
the ammonium salt. With your permission I would then like to
send you a sample for assay in the thymine-less mutant you men-
tioned as being available in your laboratory. At the same time,
I wonder if it would be possible to obtain a culture of this
strain for use here by our biologist, Dr. I. S. Johnson, to
familiarize him in this area. He is also planning work with
mouse leukemia resistant to 6-MP to test the 6-MP derivative

in vivo.

All I need is four hands instead of two. I hope you had a

pleasant and useful trip this summer, I am looking forward
to seeing you with other 5.I.M.B. members here in October.

My regards go also to Mrs. Lederberg.

Sincerely yours,

)

4

  

Koert Gerzoy oy
Organic Chemical Division

ba