; 7 4 Ministére de !'Instruction publique UNIVERSITE DE LIEGE Liége, le February, 4, 1958 1, rue des Bonnes-Villes Microbiologie et Hygiéne Prof. P. Fredericq Prof,J. Lederberg Department of Genetics University of Wisoonsin Madison 6 Wisconsin USA Dear Professor Lederberg, Thank you very much for your proposal for a lec- ture in Madison. I shall be very glad to do it. I think that I shall come to Madison around June 9 but my travel program is not yet definitely settled, I hope that the date will suit you, IT am sorry to have made a distinction between *‘virus-like" and”“plasmid-like", I really had overlooked the full meaning of the term plasmide a I am sending by the same mail phage BF.25 which is useful reagent to distinguish resistance and immunity to colicin E, Its host~strain is E.coli B that,I am sure,you have. I include also a new sample of strain TR.27 as you did find the previous one to be streptomycin sensitive, This one is at least qualitatively resistant,;for if you cross-streak it on a streak of streptomycin 10.000 ¥/m1 , there is no inhibition, I am very sincerely yours, GA fool Prof.P.Fredericq