Jepartment of Jeneties,
The Jniversity,
Adzbaston,
Bircineham, 15.

2nd ilay, 1953.

Dr. J. Lederbers,
Jepartiwent of Genetics,
Golleze of Asriculture,
University of +isconsin,
wadisgon 6, ;
Wisconsin, U.S.a.

Dear Lederbers

oS?

It was a sreat pleasure to receive a letter 7vom you aad to hear how

a. coli is setting alone. Altnoush I try to read the various papers ag they
appear, esoecisaily the reviews, LI do aot ®iad it easy to <eep up with all the
sQvauces in bacterial renetics. It is a Pasciaatins subject and I oaly wish
i had more tine to sive to .t versonally. Iam tryin: to do the sext best thins.

Jin«<s, who is 4 very brizht youny man, tas been chiefly coneerned with Paneal
Senetics, but ae is now soins to Cavaili for a time so as to sain some exoeriance

with tne methods and problems of bacterial zenetics. dhile LT do not ssy thot
bacterial senevics will thea become his chie® interest, at least he should be

eole to Keep up With the sunject and to ceep the rest of us at Least mojerntely
up to date also.

i passed your letter on to tees and Jinss and I heve disogussed it nti
Laem. ve are vt clear what would be involved in detail ia 4 system oT reqijom
ductusations ol auclear ratio with selective vroliferstion of those :
ome TO nave, by chance, the most adaptive ratlos. It seins to us, aoverer, thet
ae sjstea xs (ees aad Jinss ssw it in Psnlcillign caa hardly nave this t

: : 3G 1a it, vecerse of the hishiy coordiaated livisions of ths qucleil in
tag tip cells of the neterosaryons, tuese bains the oily esils in vnien

Ve Gal Sea, divisioa occurs. The existiar suelesr eitlos ust bo: pr
ens* FO 2 very close a oroximation, oy saca » system o? coorlinated
bo aisht be assumed, of course, that the adapuive rallo cae into bein: hy
a Poduou group, evea thoucsh, wisn ones attained, it was maintained yey
fdiaeted division; but such =a assumption wou 14 seam to us to be gratuitous,
if gytcpiasmis control e#n coordinate divis in one est of olreumsteages. it
wid surely nob be unreasonable to supsose tha
tartnersore, Such & coatrod oF ere toa
offers

 

  

   

      
    
  
 

 

AU Lous

   

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I trust that these notes will have helped to clarify the way we have
come to look at heterokaryons.

I hope,that all goes well with Mrs. Lederberg and yourself.

 

 

 

 

 

 

 

 

 

 

 

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Best wishes to you both. |
Shecorely senres eat,
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