UNIVERSITY OF LONDON

 

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_Dept.of Bacteriology. ... 8th.April,1952.

 

Dear Cavalli, .- en, Drs Obs ote.
Elon on. > Many thanks for your letter of
v 3/4/5226. . Tam enclosing a copy of a ‘letter

.: cE. Rave sent to Lederberg. ..: I hope you :do'nt
mind ‘my. answering .you in this way just now
but I. am very buey.-. I: much appreciate your

suggestion of nublighing your. joint paper. in

‘the: J.Gen.Microbiol. .-and. I: consider it an:

excellent idea to have our respective papers

in the sane number. I still: have a certain
amount of consolidation to do but this should
not take more. than. 2~3: weeks’ when I can get
down to it after the Oxford meeting next week.

I have previously told you of my experiments

on the relative efficiency of F+ X F+ and

F+ X Fe matings and you will see in my letter

to Lederberg of another experiment arising

out of these which,I think,eliminates the
possibility of a union of two haploid sets

of chromosomes,followed by crossing-over and

meiosis. It will,of course,have to be repeat-

ed but I am reasonably confident of the
resulta. I will send you copies of the |
relevant experimental protocols as soon as
these have been photographed. ‘If I: confirm
these results on the different distribution

of marker patterns in relation to

(58F+ X WF-),(WF+ X 58F-) and (58F+ X Wr)

na tings I shall,of course,abandon the term

"gamete"but I am sticking to the gene donor

and acceptor idea. My own views are

(pro
t 4
’
¢

beginning to crystalise a bit. I think the
best thing for me to do will be to send you
a typescript of my forthcoming waging paper
to the Soc.Gen.Microbiol. This will be only
a skeleton,of course,but it will be a more
precise formulation of my views at the moment
than I may have given in my letters. You
would find in it a firmer basis for comment-
ing on my theory-in your own paper and to
this I am quite amenable, - May I,too,@iscuss
your view that F+ is transferred separately
from those characters directly involved in
“pecombination"” and determines. the mating
compatibility between the mutants, as well as
‘accounting for the absence of mating between
Fe cells? %I think I have your view correctly.

“ Thank you for your offer for further
‘exchange of ideas and comments which I will
certainly take advantage of. I am sorry)
about the dinner which certainly prejudiced
& clear exchange of ideas but,perhaps,it
was'nt such a bad idea after ali! —

With best- wishes,

 

Morheal AH Wen Wat Hntntoy oi ag27/