FOLD SIDES OVER AND THEN FOLD BOTTOM UP AND SEAL.
NO OTHER ENVELOPE SHOULD BE USED

april 16, 1953
Dear Luca:

This is a postscript to my letter of the 13th. I hope I dé not
disturb you from your task of assimilating my notes.

le have just received the pre-prints of the current symposium on
bacterial adaptation in London, for the SGM. Unless you have already
had this some time, it would be unreasonable to try to digest it for
our review. I am astonished at the prevalence of the phydsiclogical-
adaptationist view-- but suppose it is the same problem the geneticist
has-always. faced in-trying to explain the miracle of evolution in terms
of modern population’ genetics. TI-.am encouraged that we should again
restata a strong (but circumspect) case along the lines of our review;
I had “ere before whether there was mich point in repeating the
argumen oe

 

The £ ip owing references can now be completed:

Potte oR, 1951 Sequential blocking of metabolic pathways in vitro.

ce. Soc. axp. Biol. Medes Mets 76:41-L6 (in place of Potter &
efidelberger).

. The fi title for Graessle & Pietrowski is "The in vitro effect of
para~aminoasalicylic acid (PAS) in preventing acquired resistance to
streptompcin in Mycohagterium tuberculosis. J. Bact. 572.459-464

I forgot to mention the reference for Dittrich:

= Bornsshein,H., Dittrich,wW., and HBline ,G. 1951 Zur Entstehung der Chemo-

Ag resigeéenz bei Bakterien. Naturwissenschaf ten 16:383—384.

[I do not suppose you are unaware of any of these references, but hoped

2 to save you some trouble in hooking any. of them up, as long as I had them

fairly close at hand. ] fe

Saye. us from the thought! But it o¢curs to me someone (namely anyone but
self} could well afford to expand, the subject of our review into a
pnograph ° “("Genetics and Chemotherapy") that might have as wide a usefulness
a8 0 C2». WorkéWork 's book on the fochemical Basis of Chemog$sherapy".

 
  
 

   

 

t am ‘very. ‘pleased ta. learn of your election as ‘the. sectional VicePresident. I could
advise you better.ag..to candidates for Presigency if I knew better just who was
“going. Either: Beadle or Tatum would be an excellent choice. I know that Sonneborn
_” ‘<fhe-going to; the Genetics® Coligress but suppose he is a bot too far removed,

How about Lwoff? Pontedorvo would be perfectly appropriate too.

As it looks now very doubtful whether I will be able to Zo myself, I must again
ask your specific advice about the filter. TI am suspicious about the advisability
of sending the entire U-tube, but will do so if you do not have access to a glass—
blower. Tt would be toc much of an imposition to ask someone to carry such a fragile
item, which then has to be wrapped in a bulky package. I enclose a sketch of the

tube. Please advise ne what to do. I have the filer atself and could send it, or
the U-tube immediately.

I am interested in your comment in reversal of polarity. Frankly, I do not see
how this can haonen under crossing conditions. Recall the experiments with %-1305
(M-T-L-F+) which provoked no prototrophs when washed eells were p}ated with ‘+F-
plus T-L-F-, but required some period of incubation in broth to effectively transfer