FEDERAL SECURITY AGENCY
PUBLIC HEALTH SERVICE

 

IN REPLYING, ADDRESS THE

December 24, 1952

Communicabie Diserse Conte:
Enteric Becleticlogy Laboratories
2. O. Box 185

7

Cnamblee, Geordia

Dr. Joshua Lederberg

The University of Wisconsin
Department of Genetics
Madison 6, Wisconsin

Dear Dr. Lederberg:

Under separate cover we have sent you the serums requested
in your letter of Vecember 14 and in addition some Worthington serum
(lw). This serum was sent since it reacts with the "nonspecific"
phases less than otner £... serums.

It is very difficult to fulfill your request for cultures
which display phase variation yet which are fairly stable in one
phase. 1 am sure you will realize tnat this is a characteristic of
individual cultures rather than of types. further, in routine
diagnosis it 1s possible only to tell whether a culture is mono-
phasic or diphasic, but without special studies one could make no
predictions regarding the relative stability of tne phases.

We have sent several strains of S. javiana, since the phases
of this type seem to be somewhat more stable than those of the
usual diphasic Salmonella. I hope you will find among these one or
more cultures which will meet your requirements. ‘he Worthington
serum was sent to be used witn tnese cultures.

1 think 1t would be very nice if vr. Spicer could visit the
laboratory. se would be very glad to see him.

For the ufficer-in-Uharge, Bacteriology Section
Sincerely yours,

A © nnn

Philip «x. tdwards, Ph. v.
Bacterlologist-—1n-Unharge
unel.e Enteric BacterloLlogy unit