Depaftment of Ganeties
University of Yisconsin
Madison 6, Wisconsin

February 23, 1953

Dear Luca:

I hope that sending this note so soon after my letter of the
2lst does not confuse you.

Hayes now writes "The strain I have seems to have reverted
“completely to Nfr/F¥ and Tam aimdoms to Wah theaettect Sf” Bit. on’
the fertility of Hfr...". I ate quoétitiy this tc you #6 Peinforce my
suggestion that Hfr be resepege for the time being. If we are to
secept the obligation to segd our immediate working materiale ta ©
anyone who asks we might as weld abandon our own expéfimental ‘work,
and settle in the position of (@evelopers of stocks fpr other's

   

5

    
 

I will be willing to. takg! the responsibility of answering Hayes".
request in the negative,. but first wished to tonsult-you about it
more fully. Eos Se - ee

   

Have I mentioned that Sidr has discovered that passing ta 58-161
through motility selection agar results in F~! I have not yet checked
on this myself, but: am doing sg-(Skaar is my colleague. working on
coli immunogeneties) ; He also? that the F+ derived from these
F- by transduction ‘are: Tess ‘m@Bile. It is not’ unimaginable that F+ as
a surface property affects thé structure or functioning of the flagella.
The procedure did»not work in a, few trials with W-1177F+, but has not yet.”
been tried widely. ©. : y meee a

   
 

 

Sincerely,

  

x

Joshua Lederberg

 

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