UNIVERSITY OF CALIFORNIA
COLLEGE OF AGRICULTURE
AGRICULTURAL EXPERIMENT STATION

DEPARTMENT OF BACTERIOLOGY
DAVIS, CALIFORNIA September Sy 1952

or. Joshua Lederberg
Department of Genetics
University of Wisconsin
Madison 6, Visconsin

Dear Joshs:

‘te arrived in sunny California safe and sound. ‘Vith those three offspring
of mine jumping around my little Ford the trip was quite amusing.

On the way out I stopved to chat with Dr. Chance, He and Yennett Clark {who
worked with Orv Wyss) are well into a combined cytological-senetic problem. Pers
haps you are already acquainted with their approach. Chance has perfected a still
different nuclear stain which has quite taken my fancy sy its simplicity, clean-
cut results and its sound theoretical basis. At least one paper on the nucleus of
daffyka sp. is in press (Stain Technology). Another on cytokinesis, which is truly
astounding, is in preparation, Perhaps you are already familiar with much of this.
As you know, Chance has been working in this field for 13 years, and this is the
first time in the vast 7 that I have seen him so elated.

Also during my travels I visited a former student of Abie Eisenstark who has
been working on transformations of Fasturella sp. This strain is lysozenic and
tre phenomenon is quite similar to transduction in salmonellae. Unfortunately,
the characters so far transformed are morrhological and, hence, difficult to score,

As usual I wish to "borrow" something. If you have ample, could you send
some ONPG? JT hoped to study galactosidase in course 104 since you have developed
such an elezant method of assay.

Again T extend the invitation to visit us your next trip west. est wishes
and thanks for all our help in the past.

Sincerely,

‘

aad

Allen o. Marr

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OM sme