FEB 1 1963 UNIVERSITY of PENNSYLVANIA PHILADELPHIA 4 The School of Medicine DEPARTMENT OF BIOCHEMISTRY 327 Anatomy Chemistry Bldg. January 30, 1963 Dr. Joshua Lederberg Department of Genetics Stanford University Medical Center Palo Alto, California Dear Josh: There were a few students of mine in Comparative Biochemistry who might fill your requirements. One of these is Bruce Levenberg, now at the Univer- sity of Michigan at Ann Arbor. He obtained his degree with Buchanan at MIT, r worked with Kaufman at NIH, and has more recently discovered some odd com- ~ pounds and enzymes in mushrooms, etc. at Michigan. He has recently described a phenylhydrazide and a unique carbamyl phosphate synthetase and appears to be more nonconformist than most. In any case, he recognizes the gold mine available when one steps off the well-worn fashionable paths. Perhaps he will be interested in your post. Walp In your letter to me, which I take as an indirect comment on my essay, you have underlined "the underlying unity of terrestrial and cosmic life", I just don't know what you are talking about; perhaps you would care to define this term. You may conceivably be right about terrestrial life, though I don't consider the evidence overwhelming if you are referring to a monophyletic path of evolution, but if you toss in "cosmic life" as well, I would suggest that you are extrapolating without any evidence whatever. You might be right, anyway, and it certainly is easier to look for terrestrial life everywhere. However, I would imagine that the nature of the assumptions used in designing the gadgetry ought to be looked at pretty closely and not accepted on faith. Perhaps I am misinterpreting that phrase, however; if so, I would really like to know what it means to you. Anyway, the job sounds like fun and I wish I were involved in it a bit myself. With best regards, I remain Sincerely yours, 2 Seymour 'S. Cohen SSC :db