CALIFORNIA INSTITUTE OF TECHNOLOGY
PASADENA

GATES AND CRELLIN LABORATORIES OF CHEMISTRY December 12, 1958

Dr. Joshua Lederberg
Department cof Medical Genetics
The University of Wisconsin
Madison 6

Wisconsin

Dear Dr. Lederberg:

Thank you for your letter and the interesting ideas. I think
you might be interested in a discussion I wrote several years ago
on some of the factors involved in immune mechanisms which should
be considered when theorizing on antibody formation. This appeared

} in Chapter XI of “Amino Acids and Proteins", edited by David Green-
berg, Charles Thomas, 1951. Since then many more have been added
such as the lack of antibody formation in spite of the fact that
antigen is present. This occurs commonly in some normal rabbits,
in “tolerant” animals and also the disappearance of Ab in the
circulation following termination of antigen injections. It is
also true that the anemnestic reaction is relative and is probably
not a life time situation.

Hope the copy of the letter is OK. Seasons greetings.

Sincerely
Mh I agp
DHC:me Dan H. Campbell

Professor of Immunochemistry