28/5/63 Dear Dr. Lederberg, I have read with considerable interest your recent article in Nature in relation to the Future of Man. This article has stimulated me to write concerning a 'half baked' idea I have had and to ask for your comments. Briefly it consists of a human-algal symbiosis. Analogous situations can be found in the animal kingdom, hydra, sponges, protozoa. The technological problems of such a relationship are enormous but the major initial consideration is whether a large enough algal population could be established to produce any quantitative benefits. The advantages on paper of such a relationship are attractive, the algae use metabolic CO2 and liberate O2 and carbohydrate providing a system immediately applicable say in long [END PAGE ONE] [BEGIN PAGE TWO] term space travel. The problems on the other hand loom large, immunochemistry, parasitism toxicology. It could also prove social dynamite in relation to pigmented people with a shielded melanophore layer. I have been purposely brief in the above outline in order not to bother you with the trivia of what may well be my stupidity. At present I am studying for a D.Phil degree in the Dept of Biochemistry Oxford. Yours sincerely Desmond Clark-Walker