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THE WISTAR INSTITUTE
THIRTY-SIXTH STREET AT SPRUCE
PHILADELPHIA 4, PA.
HILARY KOPROWSKI, M.D. PHONE: BARING 2-6700
DIRECTOR CABLE ADDRESS: WiSTARINST

October 28, 1958

Dr. Joshua Lederberg
Department of Medical Genetics
The University of Wisconsin
School of Medicine

Madison 6, Wisconsin

Dear Joshua:

I was delighted to hear from you and learn of your impending
move to Stamford and of your intention to enter the tolerance field, I am
sending you, under separate cover, copies of the few reprints of our papers
which I still have but have to apologize in advance that we no longer have
any reprints of our major work on tolerance left.

I was extremely interested to read your enclosed speculation
which I found very stimulating. I, myself, go along with you in the opin-
ion that it seems necessary to maintain the presence of antigen in order .
to maintain a state of acquired tolerance. I think that Richard Smith's
recent paper in the Journal of Experimental Medicine dealing mainly with
tolerance in rabbits to bovine serum albumin, makes this particularly
clear. So far as tolerance of homologous cells is concerned, the situation
isstill, to some extent, unresolved although experiments I have been carrying
out here certainly show that abolition of cellular chimerism in an animal
for at least 50 days does not necessarily result in the abolition of
vious state of immunological tolerance. I mist confess that I esbeety on
particularly enamored of Burnet's clonal hypothesis and have experiments in
progress, or at the planning stage, designed to try and disprove it; but it
would be too premature to discuss them at this stage.

 

With best wishes to you in your new fields of endeavor.

Yours sincerely,

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