INSTITUTE OF ANIMAL GENETICS . WEST MAINS ROAD . EDINDUP“H 9
University Department of Animal Genetics, A.R.C. Unit of Animal Genetics & M.R.C. Induced Mutagenesis Group
Professor C. H. Waddington, C.B.E., Sc.D., D.Sc., F.R.S. Telephone: NEWington 1081

NOV 1 1962

29th October, 1962.

Professor J. Lederberg,
Department of Genetics,
School of Medicine,
Stanford University,
Medical Center,

Palo Alto,

Californie, U.S.A.

Dear Joshua,

I am afreid I do not know anything about the mutagenic or
teratogenic effect of BromoUracil in mammelien materials. I am
fairly sure that no mutagenic effect has ever been reported, but
my knowledge of teratogenic effects is extremely limited.

The only paper which comes to my mind as having a remote
bearing on the question is that by Djordjevic and Szybalski in
The Journal of Experimental Medicine 112, p. 509, in which they show
that incorporation of the analogues into the DNA of human cells increase<
radiation sensitivity.

Kind regards,

Yours sincerely,

hokk ei eee ree,

C. Auerbech.

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