II

‘

Sonneborn mss.
Manuscripts Department, Lilly Library

Indiana University, Bloomington, Indiana

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January 6, 1948

Dr. Joshua Lederberg
Department of Genetics
University of Wisconain
Madison 6, Wisconsin

Dear Lederberg:

The point you raised about the multiplication of
kappa has been considered and I think you will get the
answer you wish from Preer. The full paper on this is now
in press and should appear shortly in Genetics. Ottierts
paper, on the other hand, which is the mathematical basis
for mich of the work, has not yet appeared and I do not
know where it is scheduled to appear. As Preer will tell
you, the data show that kappa miltiplication is first order
autocatalytic at low kappa concentrations.

Quite aside from the slant you have on the situa=
tion, doesn't it seem a little difficult to conceive of
kappa duplication taking place at the locus of K when Preer's
estimate of kappa size make it, as I pointed out in Chicago,
more near the size of a chromosome?

With best wishes,
Cordially yours,

7, M. Sonneborn
TMS set