ee THE UNIVERSITY OF TEXAS AUSTIN 12 DEPARTMENT OF BACTERIOLOGY i Auguat 1951 Dr. Joshua Lederberg Genetics Department University of Wisconsin Madison, Wisconsin Dear Dr. Lederberg: We are rather puzzled by some results which we have obtained with the sexual recombination of streptomycin resistant forms of E. coli. In data obtained in an attempt to determine whether there are several loci are involved in the various grades of streptomycin resistancey ‘here are a number of unexplainable (ito us} discrepancies. “It has occurred to me that perhaps you have already worked out this problem, If this is the case, I would appreciate it if you wouid advise me to that effect as I am looking for an excuse to abandon it, I wonder if you are planning to attend the Biochemical Convention at Brookhaven this month? Very truly yours, OW:je