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Manuscripts Department, Lilly Library
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seonneporn mss.

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444190 MGAVELD LAL

_is covered by copyright and may not be
/ quoted or reproduced without

DMR ARE EE VO Ly @
of copyright holder.

 

permission

 

 

CARNEGIE INSTITUTION OF WASHINGTON

DEPARTMENT OF GENETICS

COLD SPRING HARSOR, LONG ISLAND, N.Y.

April 11, 1947

Professor Te Me Sonneborn
Department of Zoology
Indiana University
Blooningtons Indiana

Dear Sonneborn:

It was very thoughtful of you to write us in connection with our
daughter's success. We appreciate it.

I hope that now that we have a method for treating Drosophila
with chemicals it will be possible to find a number of them to be gene-
tically effective. So far we have satisfactory data showing that
dibenzanthracens induces mutations and chromosoma breaks. The experi-
ments with methylcholanthrenes, benzpyrene, and beta-naphthylamine are
suggestive but have not progressed far enough for a final conclusion.

We are very much excited about Dr. Witkin's very suggestive
results that desoxycholate and pyronin induce mtations in coli. Both
of these chemicals combine readily with nucleic acids.

With best regards,

} Sincerely yours,

(VV

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