FEDERAL SECURITY AGENCY

U.S. PUBLIC HEALTH SERVICE
NATIONAL INSTITUTE OF HEALTH

 

IN REPLYING, ADDRESS THE BETHESDA 14, MARYLAND

Experimental Biology
& Medicine Institute

July 2, 1948

Dr, Joshua Lederberg

Assistant Professor of Genetics
The University of Wisconsin
College of Agriculture

Madison, 6, Wis.

Dear Doctor Lederberg?

I may be wrong but I do not feel that des-
oxypyridoxine is an antiphage agent in the sense that
the compound has a direct effect on phage production
similar to that of a germacidal agent on bacteria
multiplication, Our experiments indicate that des-
oxypyridoxine acts by inhibiting the utilization of
glucose by the virus, The phage seems to adsorb to
the host cells readily enough and virus multiplication
occurs at a normal rate for the first hour and later
slows down in its rate of growth, brought about, we
believe, by deficiency of nutrients, viz,, carbohydrates,

I have a very limited supply of desoxypyridoxine
on hand but Merck & Co,, Inc., Rahway, N, J., has deen
very generous in supplying my needs of this compound,

If you will write to Dr, R, C, Pogge, Medical Division of
Merck & Co,, he will probably supply your needs,

Very truly yours,

f Bil

Jerald G, Wooley

  
 
 
 

JIGW: tey