INDIANA UNIVERSITY
BLOOMINGTON, INDIANA

November 11, 1952

Dr. Joshua Lederberg
Department of Genetics
University of Wisconsin
Madison 6, Wisconsin

Dear Joshua:

Freeman was here and talked much in general, but little about our
book,

Your formula for progress sounds good, but I'm not sure I can
adhere rigidly to avoiding reviews and general papers altogether. For
example, I agreed a few years ago to write a review on our antigen work
for Experimental Cell Research. This will force me to get some of our
results together and that is to the good. Nearly two years ago, Kalmus
gave Heinemann in London a manuscript of mine on Cytoplasmic Inheritance,
which they want to publish as a little book. I have refused to permit
this without revising it and I haven't made the revision. I have been
asked to present a "critical review" at the Genetics Congress and feel
this can hardly be turned dewn; but I have no definite idea yet as to
subject. Could you suggest one that might be useful as preparatory
material for our book? Naturally, I'd like to take this opportunity
either to set farth parts of our own work or to tackle some more general
theme in GOM or cellular genetics, All these efforts will have some
value in relation to our book, though they may set back the timing. Do
you really think I should turn any or all of these things down?

Without fully understanding the details of what you write about
Salmonella, 1 grasp just enough to be very intrigued by the way things

arg FUE and lock forward to hearing more in time. HS Fravghf tock a puller accout

Inoki did not offend me at all. On the contrary, I may have
offended him. He asked me to support his application to Harvard and
I wrote that I felt limited in what I could say because the questions
and comments I raised about his first communication to me had never
been answered. He said he answered about the time I went to South
America and the letter seems to have been lost. That set things straight.

As to his system of results, I think the regular return to type 0
may be misunderstood and that he is placing undue stress on this. The
type one starts with is likely to be the one best adapted to, or most
likely to arise under, the conditions employed. Reversion may mean only
that. We find similar things. For example, at 31° in stock 51, we
have type A. It can be transformed to other types but if the latter
are again exposed to transforming conditions at 31", they regularly go
Dr. Joshua Lederberg--2

to A. If the experiments are done at u4°, however, type H takes the
place of A and changes from H revert to H at the next transformation.
I have intended to write this to Inoki, but haven't done so yet. Mean-
while, I'm trying to make it possible for him to get to this country.

Best regards to you and Esther and the Skaars,

Cordially,

Taney
T. M. Sofneborn

TMS: jb