Columbia University intheCitpefHewPork 27 LABORATORY OF BIOPHYSICS November 29, 1946 Mr. Joshue Lederberg Osborn Botsnical Laboratory Ysle University New Haven, Connecticut Dear Lederberg: Thank you for your kindness in sending several reprints recently. The idea about cancer being a reverse mu- tant is certainly a sensible one, and I hepe it leads to some good experi- mentation. Yours sincerely, a wr” rr CG = Selig Hecht