CABLE ADDRESS ‘‘RESEARCH”

IN YOUR REPLY PLEASE QUOTE

 

NATIONAL RESEARCH COUNCIL
CANADA

ATOMIC ENERGY PROJECT

AIR MAIL CHALK RIVER. ONT.

duly 13th, 1950,

Dr. Joshua Lederberg,
College of Agriculture,
Universitv of Wisconsin,
Madison 6, Wis.

Dear Joshua,

Enclosed is a manuscript on the peculiar
segregation in BE. coli, which I am on the point of submitting
to the American Naturalist. Before doing this, however, I should
be grateful to have your criticisms.

In parfiicular, is there anything in the
heterozygote story to render the present somewhat conventional
approach unjustified? I have had in mind the matter of gene loss,
but have assumed that it occurred after the initial crossing
over anc partial segregation which seems to take place in the
formation of the heterozvgous strains. If this is so the present
story would seem unaffected. Your may, however, have indications
of a much less straightforward chromosome behaviour.

Rothfels is with us acain this summer and
is working on a similar problem.

Sincerely,
4,

Howard B. Newcombe
HBNsbe