October 5, 1953 Dr. ©. S. Lindstrom Department of BacterLology Pennsylvania State College State College, Pennsylvania Dear Gehe: I have your letter of September a, and am under separate cover. May Inalso intrude a caveat, whic what hesitant to bring up except thé you 7 it, and will keep it strictly persofal. work with which lis, Berry was connected at Amherst (and for whigh she is presumably responsible to the extent of authppship on the papers) has duffered from/grave aechnical mishaps— reflected for example in the mixed cutt gh Linally"explained" (rather reluc— tantly, but under the dtrongss satre_frof Other workers)in P.NeAS. 37:640/ and also in the inconsistencie» aper in P.N.A.S. 38:797; compare with Microb. Genetics Bull. Febr. 3 p.17, and also his private statement that p uctdons cannot be "consistently" obtained P do not mean to imply that anything more is required than a caref? techdhque. I suspect that many of the incon— sistencies may stem from \the sverae auxanographic" method of testang nutritional requirementa.\Mutagenic effedts-are some of the most difficult to evaluate, and more than usual\attention has to be paid to experimental design and its execution in this field. and many no longer react As Sincerely, . - Joshua Lederberg