DEPARTMENT OF
TAALTE, ae 7 —_

 

¢ Public Health Service
NATIONAL INSTITUTES OF HEALTH © Bethesda 14, Md.

 

NATIONAL INSTITUTE OF ARTHRITIS AND METABOLIC DISEASES
NATIONAL CANCER INSTITUTE

NATIONAL INSTITUTE OF DENTAL RESEARCH January oO 19 56
NATIONAL HEART INSTITUTE ’

NATIONAL INSTITUTE OF MENTAL HEALTH

NATIONAL MICROBIOLOGICAL INSTITUTE

NATIONAL INSTITUTE OF NEUROLOGICAL DISEASES AND BLINDNESS
THE CLINICAL CENTER

DIVISION OF RESEARCH GRANTS

Dr. Joshua Lederberg
Department of Genetics
College of Agriculture

The University of Wisconsin
Madison 6, Wisconsin

Dear Dr. Lederberg:

Reprints for the paper you recently requested have not come
in yet, but as soon as they do I shall send one along.

In regard to the enzyme system possibly involved, we have made
some preliminary determinations but nothing definite can be said
so far. It looks, however, like there may be no differences in
enzyue activity levels between the long-sleeping and short-sleeping
@ strains. If this is the case, the basis for this difference may be
tied up in some way with differences in sensitivity due to the
theoretical receptor centers. This hae some interesting implications,
and this mouse material may prove to be suited for experimentation on
this theoretical mechanism.

As to the atropine esterase system in rabbits, I know of no
other work than that of Glick and associates and Bernheim and Bern=
heim. However, Dr. Sawin may know, and an inquiry to him might be
worthwhile.

Thanking you for your interest, I remain

Since Ne Te

iz Me.