May 29, 1955 Dear Miss Husted: Thank you for your letter and for the 22d ed. oz your dictionary. The "Stedman" T haa purchased as a medical student needed sone fresheatag. Ae { would consider the maintenance of an accurate and up-la-date techni- cal dictionary in the life seiences one of the most urgent snd necessary tasks to help rapidly diverging specialities conmmmicate with one anotheb, I heve gone to some effort to look over the terms you referred beck to ne, as vell as some others, I am sending you my accumulated notes, But T Rear I could only scratch the surface in the time I cowld spend at moment, I hope my remarks are not gratuitous, but I an truly sorry to nave to say that a preat deal of work would be needed to revise the dietionary to mare it truly useful and reliable et least in the fields of my ova interest, genetics and bacteriology. A good deal or ppace is devoted to isems tiat Lave died since about 1910; for others meanings have chanved slightly, or the ori- ginal definitions were not expertly fremed, The coneats ars only an initial sample, My criticism, which as T em sure you realize ig offered in # trlendly and soastructive vein, need evoke no aphlocies, Your competitors have dence neo betters the task is simply too large to be handled except by a rather larrce group of copperating experts, the cost of whose consultative servicer may be prohibitive. On the whole, ths unabridged dictionaries have done a more accurate joby but even with their larce etaft's, they could not so into the technical: deteil that would b expected in an onterprise like yours, The objective is too important to be left undone in frustration. I would sug gest thet either your conpany consideré enlarging its technical statx (with the inevitable undestrable rasult of cost increases) or approaching the Anericaa Institute of Biological Sciences an] the Anerican Medical Association Lor help in trying to orgatize an adequate consultative hase. The AISS has been excenting @ Job in copperstion with the National Research Council, and with federal sum port, namely the Handboo: of Biological Vata, which I would consider rather less important than the job of setting up a really complete and reliable technical dictionary, T do not think: mere bulk would be » limiting factor the work I have in mind could de encompassed within the present size volume, particularly if derivatives bearing an obvious relationship to the root worii were omitted, and the deadwood relegated to a dictionary of antiquities, < @ @ To change the subject, may I comment on derivations? It often happens that new words are modelled after existing English terms, rather than the ultinste classical roots, Then, to quote Gk. gen- rather then English gene as the source word of compounds may be misleading (ae it would be in heterocencte). Perhaps a better example is the words in some, which are really modelled after Chromosome, and not the ultimate soma; or better still, the compounds of -ploidy which are modelled after the word ploidy itself, which is in turn an enpiricel abstraction from haploid, diploid, ete., rather than a derivative af any (which?) Sreck root. I have tried to indicate this process in my ow comments. I kitedomwx believe that to present to factual English model word, where it agists, is more reelistie than to go back to the classical origins, which can always be deduced from the prototype in any case, One more instances psovdesllele ts Just Eng. preudo-~ end ailelb: it could never nave been independently derived from "felse® and"@1fferent", the allele having come by contracwion from allalonerpi, widen was ef classics. conctenction, I realize there is some variance in prectice along these Lines, and I actice that the 224 Ed. orten accepts prefixes, but usually not suffixes, on the temas I peegented, E.G. why not, glycorriea us just glyco- and-rrhesz, both of which are Listed as combining formas, or, even better glycosoneter, etc, These sxeples ure not so telling, simee the combining forms are se close to tue classical that tho conpéunds might have been rixewkin derived equally well from either, which is less often true iy genetic 7 neolovy, (since there wes no classical genetics). MP ee ges ng Bo cp nee, eee Yours clings. Tey» JOshux Lederogrg Professox of “euebics not gan, TERMS ESTABLISHED IN GENETIC LITERATURE, SUGGESTED FOR INCLUSTON holandric —e inherited oxclusively through the acle descent; signifies genes located on the Y chromosome, chromogene (chromosome ~ and -gene) a chromosomal gene, as distinguished from extrachromosomal chromogenic biopoisesis aeropause 2. pertaining to chronogene origin of life from inorganic matter region of and beypnd the earth's atmosphere tantenount to Tree space axenic (a! gen ig) (a- xenos) in pure cultures free from foreim organisms, serotype lysetype imaunogenetics histoconpatibi lity lysogeny, lysorcenicity mutacen mutegebécs mutafaciont karyotype allopelyploid autophbyploid taxonomic subdivision based on antigenic analysis; a tomula describing such a subdvision, taxonomic subdivision of bacteria based on reactions to specific phageas a formula describing such a subdivision. branch of genetics concerned with the inheritance of antigenic and other characters related to the imaune response, 1. the sbility 6f a graft to shrvive homo or hotero~ transplantation. 2, the relation of transplant to host and its gonetic basis, lysogonesiss the synbioais of bacterium with phages the potentiality of a bacterium to produces « phar. a chenteal or physical agent that induced mutations, the propert or act of inducing mutations, the chromosomal constitution of a cell, individual o: apecios, an orgentem naving a polyploid chromosore set derived frou two or mors parental spectes/ ile an organism heving . polyploid chromosome set der? vad £ a > Ly ne on eee, ao “at atone trom the reloubling of chromosoues cis simvle spaces. SUGGESTED TEAS polysomy (poly- and chromogoges) an excess ef a particular chromosome. polysomety (deriv? prob sane) reduplication of the total chromatin in the nucleus, with or without obvious polyploidy, Often used as synonym for endopdivploldy. endopolyploldy reduplication of total chromatin as a result of endomitos! . without visible increase in chromosome number, coments on some definitioas genone The definition given is not correct, (I+ was doubtless furnished by Dr, Davis by analogy with phenome, but this uaage oF genous hag not been introduced into the iiterature, and I nope will not be. The usefulness of the definition below, contra genotype, has been that a hybrid may contain two Or more genomes. Genonic analysis tius means explicitky the investi-~ gawlon Of & presumed ellopolyploid to determine the uitlnate parentage). Defs 2 single busie set ci’ Yeucs, ubudily & bepioid complement ag carried by a gaaete. In éliopolyploids, exch haploid seb constitutes one gengone, heterotrophic fie intergolation of growth factors is coniusiag. The tera is usnally &pplied to orgenisas wich vequire a reduced goma of carvon ior energy anc synthesis, (glucose ig nov usually cunasidered a growin iacvor)/ autotrophic vos, We Gupdedib da vitasias is ulsplaced. Se some green plants (sugleas) cequire yrowih factors ia smal amoulis, bub, uy extension, or Watier resteletioa te bue Gr-sOucve, uve ubill classed as autotrophic. biose 1. a sugar containing 2C atous (= only giycelalideiyde), by enslogy with irlose, hexose..., bus imslly evex used in this sanse. 2/ a disaccharide, bloside then becomes & glycoside conteining s biose + aglycone, blotaxis, biotropian no Meunings analogous io chenotexis, chemotropisn’? biparasite ?¢ = nyperparasiie, COMMENTS ON DEFINITIONS IN 224 Edition ; Cc x obsol. if ever current; have you a citation micronucleus ~ all wrong, 1. In eiliate protozoa, the analler of two types of nuc&éus in each cell, required for sexual but not for vegetative reproduction, Ci. macromecleus, 2, karyomere q.v. karyomere (I am not acqgainted with these usages, for 1 certainly ?c) & vesicle containing only a small portion of the total mass og the typical nucteus, usually following mitotic abnemeality. translocation add: in genetics (usually reciprocal t.), the reimion of one part of « broken chromosome with part of enother. inversion adds in genetics, the invergted reunion of the interstitial segment after breakage of one chromasome at two points, blomone, biomore, biomitation, biomonad » biochemy (German 7), dloplesmin, biorgan genesistasis ?e I would heve ressoned this to mean interruption of development, xenia include ...from the male (pollen) parent.... gen (for gene) 2c German! heteroplasty in transplantation genetics and probably generally is dist. from homoplasty., The former implies a different species, the latter a different individual of same SUD. Iutagenic 2. inducing genetic mitetions, X~ chromosome (under X?) The differential sex chromosome carried by ¢ the male and all female gametes in man and other nale-haterozanatic species, i~chromosoms (under ¥?) ‘The differmatial sex chromosome carried by + male ganotes in man and some other male-heterncanetic species where the homologue of the X-chromosome haa been retained, dletin correct structural formila— the thiophene ring is omitted) bisanylose te theory ?ea douin still comtemp? (£1. ¢ 1900) genetotrophic fe meaning? (T recall possibly heaving seen this in the sense of pathology of genetic etiology) inheritance define} Most of the categories are obsolete or ?c. You might rete: . criss-cross, with note to sexlinkeds extrachromosana] (¢ cytoplaanic) § and mmutkak mondelian., Holandriec and hologynic (spell!) might be define’ under their own headings and the other: deled, here, inhibin 1, what does this mean? antibLotin any antagonist of biotin, not just avidin colibacillary-antic, compare E. coli/Bectllus coli azoxybenaene formula as given is misleading. C6H5.N.(.0.)N.C6H5; no N:N bonds.