8-16-48 EB AND MI Dear Dr. Lederberg--I haven't answered your letter before this, because I hoped I'd get around to testing that galact-lactose bug and could give you a report. But I haven't yet, as I want to finish up incomplete lines of work first. I'll let you know as soon as I know. Yes, I have considered using drug-resistance and, in fact, fooled around with streptomycin resistance (by plating) for a couple of weeks, early last spring but didn't get very encouraging results. I may get back to it sometime, if nothing better works but for the forward-backward measurement problem. Give my regards to Mrs. Lederberg. Yours, Bob Guthrie