CHEMICAL CORPS MEDICAL LABORATORIES

ARMY CHEMICAL CENTER, MARYLAND

IN REPLY REFER TO:

CMLRE-ML (B)

Dr. Joshua Lederberg
Department of Genetics
University of Wisconsin
Madison 6, Wisconsin

Dear Dr, Lederberg:

Your recent request concerning the availability of DFP for
experimental purposes has been referred to me for necessary
action.

We are prepared to supply you with one gram of DFP for
experimental purposes, without charge, Please fill out, sign
and return to me both copies of the inclosed "Statement of
Investigator" and I will take the necessary action required to
supply you with this material,

Offhand, I do not believe that studies of the kind you
propose have been carried out, The most closely related study
may be the demonstration of AcChE in the fibrillar fraction of
Tetrahymena geli\eii by Seaman (Proc. Soc. Exptl. Biol. Med. 76,
169 (1951)); and I believe that Kidder has demonstrated inhibi-
tion of fibrillation in Tetrahymena by DFP in rather high doses
but I cannot give you a reference for this. We have also demon-
strated the same effect in our laboratory several years ago.

Yours truly,

AL

‘BERNARD J. JANDO
Incl, Acting Chief, Biochemistry Division
Statement of Investigator

JBhe FASS” (FH