FEDERAL SECURITY AGENCY «+ Public Health Service NATIONAL INSTITUTES OF HEALTH © Bethesda 14, Md. NATIONAL INSTITUTE OF ARTHRITIS AND METABOLIC DiSEASTS Oc tober 10, 1951 NATIONAL CANCER INSTITUTE NATIONAL INSTITUTE OF DENTAL RESEARCH NATIONAL HEART INSTITUTE NATIONAL INSTITUTE OF MENTAL HEALTH NATIONAL MICROBIOLOGICAL INSTITUTE NATIGNAL INSTITUTE OF NEUROLOGICAL DISEASES AND BLINGNESS THE CLINICAL CENTER DIVISION OF RESEARCH GRANTS Dr. Joshua Lederberg University of Wisconsin College of Agriculture Madison 6, Wisconsin Dear Josh: Many thanks for letting me see the enclosed paper in advance of publication. The method you describe has a classic simpli- city; and the results obtained with it seem perfectly clear-cut. For a number of reasons I have not beenable to push our resis— tance studies as fast as I would have liked. I am, however, now writing an introductory paper,and when it is ready, I would welcome your critical comments and suggestions. With kind regards, Experimental Thepfapeutics National Microbiological Institute HE:km Enc.