LoNnG ISLAND BIOLOGICAL ASSOCIATION
COLD SPRING HARBOR, LONG ISLAND

January 15 3
THE BIOLOGICAL LABORATORY anuary 16, 195%

tr. J. Lederberg
Genetics Department
University of Wisconsin
Medison, Wisconsin

Dear Dr. Lederberg:

The purpose of this letter is to invite you to participate in the XVIIIth
Symposium on Quantitative Biology at Cold Spring Harbor, June 5 to 11, 1953.
The topic of the meeting is to be 'Viruses."

The program deals with certain basic concepts of virus research, starting
with the states of viruses (infective virus, vegetative virus, and provirus)
and the transitions between these states, It is felt that one of the principal
purposes of this Symposium should be a clear exposition of the evidence for the
existence of different states of viruses, and a reinterpretation of many previous
observations in the light of newly developed concepts. Another important purpose
is to bring together workers doing research on animal, bacterial, and plant
viruses for free discussion of the many problems they have in common.

A copy of the tentative program is enclosed, It has been worked out by
Dr. Max Delbriick in cooperation with several collaborators. We propose to have
two or three papers by invited speakers, followed by discussions, on each of the
seven days of the meeting. Each day's chairman will preside at the sessions,
and will correlate the discussions for publication.

The National Foundation for Infantile Paralysis has generously agreed to
sponsor this Symposium, You will be allowed a maximum travel allowance of
% 108.22for transportation to New York City, and $15,00for incidentals,
including local transportation. The National Foundation will take care of your
living expenses in Cold Spring Harbor during the seven days of the Symposium.

I hope that you will find it possible to take part in the Symposium, and I
will appreciate your filling out the enclosed sheet and returning it to me at
your earliest convenience,

Sincerely yours,

J VAC UAE

MD:eb M. Demerec, Director
Enclosures
TENTATIVE PROGRAM
XVIIIth Cold Spring Harbor Symposium on Quantitative Biology

Friday, June 5, to Thursday, June 11, 1953

VIRUSES

 

Friday, June 5. Chairman: E. L, Tatum

Introductory Remarks About the Program

 

M. Delbrick
Virus in the Vegetative State and Its Maturation

A. H, Doermann: The existence of vegetative phage, as inferred from intra-
cellular growth curves and from genetic recombination experiments,

Discussion: Visconti (effects of timing on genetic ratios); Dulbecco

(experiments with T3); Appleby, Hirst (experiments with Influenza),

C. Levinthal: Maturation of phage. Evidence regarding transitional forms
between vegetative and mature phage.

W. Henle: Maturation in animal viruses,

Discussion: Schlesinger, Sanders.

 

Saturday, June 6, Chairman: F, K, Sanders

 

 

Provirus

J. Bertani: The distinction between the prophage state and the vegetative
state. Compatibility relations between different prophages,

Discussion: Schlesinger (applications to animal viruses),

W. Hayes: The mechanism of genetic recombination in bacteria,

Discussion: Appleyard, Lederberg (interrelations between phage and
bacterial recombination)

 

The Transition from Provirus to Vegetative Virus

F. Jacob: Induction in lysogenic strains of bacteria,

Discussion: Lwoff (theory of induction); Lieb (transition from infective
state to prophage state),

 

Sunday, June 7, Chairman: R, Herriott
The Transition from the Infective to the Vegetative State

A. D, Hershey: The injection of DNA.

R. Markham: Chemistry of functional components of viruses,
Discussion: Hirst (enzymatic attack of the Influenza virus on the host

ee

cell); Mommaerts (enzymatic attack of the avian erythromyoblastic
leukosis); Puck (attachment of viruses to their host cell).

Afternoon Free
Monday, June 8. Chairman: J. Beard

Structure of Viruses

 

R. 0, Williams: Morphology of Viruses.

Mark Adams: Evidence on structure from effects of ionic environment on viruses,

Discussion: tT. F. Anderson (osmotic effects).

F. Lanni: Virus antigens as associated with structural and functional com-
ponents of viruses.

Tuesday, June 9, Chairman: A. Lwoff

Biochemical Studies of Virus Infections

L. A, Kozloff: Source and fate of phage materials,

Discussion: 5B. Commoner (experiments with tobacco mosaic virus).

3. 5, Cohen: ietabolice changes in the host induced by virus infections,

 

Host-controlled Variations of Viruses

 

S. E. Luria: Analysis of hostecontrolled variations in phages and e discussion
of various observations with animal viruses possibly related to it,

Vednesday, June 10, Chairman: G, Hirst

 

G. Bowen: UV inactivation, photoreactivation, and multiplicity reactivation,

 

N. Zinder: Type transformations induced by DNA preparations and transduction
of genetic markers by phage.

afternoon Free

Thursday, June ll, Chairman: J. imders

Viruses in Tissue Culture

R,. Dulbecco: Application of plaque techniaue to animal viruses.

Discussion: Syverton, Selk,

A. D, Hershey: Summery and conclusions regarding phages,

 

 

F, Horsfall: Summary and conclusions regarding animal viruses,