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TeterHone PADoincton 1148 THE WRIGHT-FLEMING INSTITUTE OF MICROBIOLOGY,

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ST. MARY’S HOSPITAL MEDICAL SCHOOL,
PADDINGTON, LONDON, W.2.

V

17th September, 1953.

Dr. J. Lederberg,
Department of Genetics,
University of Wisconsin,
Madison,

Wisconsin,

U.S.A.

Dear Dr. Lederberg,

I am writing this in the absence of Dr. Fowley
who is at the moment at the Fasteur Institute and who I
believe has been in communication with you regarding the
availability of virulent coliforms for use in recombination
study.

I have been associated with Dr. Rowley in the
investigation of the genetic localisation of the marker for
resistance to inhibition by norleucine in K12 and its
auxotrophic mutants.

During the course of this work, a preliminary
report of which was read at the Rome Congress, we had
occasion to investigate the sugar fermentation characteristics
of progeny from matings involving strain W677. These
differed significantly from those published by you in
collaboration with Dr. Cavalli-Sforza using strain WOL5 and
certain sugar fermentation markers carried by these two
strains are presumably non-allelic. Dr. Cavalli-Sforza
has promised to let us have a culture of this latter strain
in order to compare our results.

We noted a reference made by Wellmann (1953)
Ann. Inst. Fast. 84, 280 to an unpublished paper of yours in
Genetics, quoting the allele for Ga@é fermentation in W677
to be Gal
Dr. J. Lederberg, 17th September, 1953.

I would be grateful if you would let me have a
copy of this communication if available, or if not if you
would be so kind as to provide me with the details of the
sugar fermentation markers carried by these two strains.

Yours sincerely,

tyne