May 21, 1957

REPORT ON RESEARCH FROJECTS
for the
FISCAL YEAR 1956-57

 

 

 

I. Name Lederberg, J. Dept. Genetics Proje Nos 562 245
Title of project Genstios of Bacteria
Robert E. Wright ] Graduate students: researeh assistants
II. Personnels Totaue Lino 4

Jean Falvorsen

III. Statement of other financial support, if any, for this projects

NIH 8 500 Rockefeller 6,000
NSF 7 909

IV, Brief statement of specific progress made during the year:

1. Bacterial L-forms consia’ of ontgrowuns of rall~less bacteria (i.e. protoplasts)
in a confining agar milieu. Tne loss of tne wall may ve occasioned either by inhibi-
tion of its syntiveis, by panteillin, or by internal gamtic blouks, e.2. of the
biosyuthesia of diamino-nimealic acid.
2. Efforts to inportddf DNA into protoplasts for genetle effect have au far failed.
3. Further mitationa influencang the ayathesis of fisgeil.r proteins hive been iden-
tified and characterized. Theres is a chain of comin synthetic steps, followed by
two divergent, and competliive, pativiays.
4. Host mutants influencing galactose fernentabion in 7. voli have «a simple physlolo—
gicul genstic pattern: ous group, ia which galsfoltin.se is dsficieat, form a single
genstic rogition-alfact sut (cistron), and the sams for a secon, in videh the missing
enzyme is a Uridine-Diphosphate-laxoss transferase. However, there are additional
woaieh don all int: is stlucla set °
Ve mutate thon that bist laphearon in sae? Fehon nay 1, 1956 to June 30, 1957.

Sen attrehed sheet (lieos cheated)

VI. Manuscripts accepted for publication but not yet printed:
Viruses, gones and cells. Bacteriological Reviews

The pink copy should be returned to the Graduate School Office on or before
August 1, 1957, The blue copy is for your file.