REQUEST TO RESEARCH COMMITTEE FOR RFSFARCH SUPPORT, 1956 ~ 1957

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Submitted by Professor Joshua Lederberg, Department of Genetics, January 5, 1956
TITLE AND REASONS FOR STUDY RESULTS OBTAINED TO DATE

Genetics of Bacteria: a continuing program on life cycles and genetic mechanisms
of bacteria and other microbes. See attached sheets for detailed report

PROCEDURE AND PERSONNEL

All laboratory work will be conducted in the Denetics Department, and will
be an extension of current studies. The partial problems will be handled as
follows:

Trandduction in Escherichia coli; relationship of provirus to bacterial genes.
Dr. F. M. Lederberg; Dr. J. Lederberg; Dr. M. L. Morse (to June 1956)

Sexual conjugation in F. coli. Dr. N. Morton; Dr. J, Lederberg

Cytoplasmic transmission in yeast dikaryons. Mr, R. EF. Wright

Transduction in Salmonella; genetic control of flagellar antigens. Mr. T. Iino*
Biophysics and genetics of sexual compatibility in ©. coli. Mr. Alan Richter*

*These assistants, now supported by WARF funds, have proved to be excellent
graduate a@adents and researchers. I have never before had such a consistently
good group. Mr. \iright's work last year was set back by a serious auto accident
but he has now resumed at his former stride. Mr. Richter is a WARF fellow; the
budget below is based on the assumption his appointment will be renewed, which
I am happy to recommend. Miss Ruth Zlcten was intended as a fourth assistant
last year but she has joined a related project with Professor D. T. Berman.

The budget request provides for the renewal of these appointments, with the
possible additicnsBf a student to be selected from current applications.

FINANCIAL SUPPORT

During the past tw years, the Committee has awarded funds for four assistants.
Last year, two appointments were vacant, but the funds were used to met urgent
and unforeseen needs; they were rearranged to pay the salary of one full~time
nonstudent assistant. This is now to be supported from other funds, and the
assistantships now requested are intended for their usual appiication to gradu-
ate assistants.

Budget 3 Twelve-month assistantships, at $1560 4 680
(Wright; Iino; -—)
Hourly Help (dishwashing) 500
Equipment (small air-turbine centrifuge
for concentrating phage) 200
(Contingent request; assistantship for Richter 1 560)+
Total & 5 380

*“tRequested for the contingency that his WARF fellowship will
be terminated.