May 19, 1954

FEPORT ON RESEARCH PROJECTS

 

 

for the
FISCAL YEAR 1953-54
I. Name ED 'RB'RG Joshua Dept, Genetics Proj. No, 53% 326
Title of project Bacterial Genetics

 

II. Personnel: Helen L. Byers
Aleck Bernstein

III. Statement of other financial support, if any, for this project:
Watioml Institutes of Health: $ 8 500

Rockefeller Foundation 6 000
IV. Brief statement of specific progress made during the year:

A morphological basis for genetic recombination in F. coli has been visualized
for the first time. ith the proper combination of parents, a few percent of the cells
form microscopically visible pairs which remain attached about 1-2 hours. The exconju-
gants then show a very high incidence of genetic recombinants » supporting previous
inferences of a sexual mechanisa, In addition, the inherdd#itance of incomplete
genetic factors (capable of functioning without reproducing) has been stul ied in the
Salmonella transduction system.

V. Publications that have appesred in print from July 1, 1953, to June 30, 1954.

TAMA! Lederberg,J. and Tatum, F.L., Sex in bacterla: genetic studies, 1945-1952.
Science 118: 169-175, 1953
Stocker, 3.A.D., Zinder,N.D., and Lederberg,J., Transductipgsef flagellar
characters in Salmonella. Jour. Gen. Microbiol. 9:410=433

VI. Manuscripts accepted for publication but not yet printed:
Nelson, T.6.g aml Lederberg,J., Post-zygot&® elimination of ymetic factors
in E. coli. Proc. Nat. Acai. Sci. U.S., 402415-419. 1954.

Lederber g,J., Genatics and Microbiology. Rutgers University Institute of
Microbiology, Dedication Sympesiua, In Press.

Lederberg, J., Recombination mechanisms in bacteria. Symposium on Genetic
Recombination, Oak Ridges National Laboratory, In Press.

The pink copy should be returned to the Graduete School Office on or before
August 1, 1954. The blue copy is for your file.

Cavalli-Sforza,L.L., and Lederberg,J., Genetics of resistance to bacterial
inhibitors. Symposium on growth inhibition and chemotherapy, International

Congress of Yicrobiolo Rome, 108-142, 19
derber gadey ai denne P.Re, aeectitte Pécombination in Salmonella.
MANO,

our. e vale 2320 21,0. 1953