June 12, 1953

REPORT ON RESEARCH PROJECTS

 

for the
FISCAL YE4R 1952-53
I. Nee LEDERBERG, J. Dept. Genetics Proj. No. 326335
Title of nroject: Bacterial genetics

 

ZT. Personnel: H. L. Byeran(part NIH)
M. L. Morse (part AEC)
Be R, Lively (to 8/31/52)

i. Statement of other financial support, if any, Yor this project:

Nations. Institutes of Health § # 500
Chemical Corps (to terpinate 9/53) $ 4 500 [for 152-53]; A.E.C. [terminated 3/53]
Rockefeller Foundation $ 4 500 [for 152-53] $1 250 in 52-53.

IV. Brief stetenent of ssecific progress made during the yeer:

Studies were continued on the mechanism of genetic transfer in bacteria. In 3alm-
nella, phage rartdeles were shown tto tranaduce smell genetic fragments. This was
applied extensively to the synthesis of many Salmonella types. In E. coli, the
physiclogical conditions remired fer optinal rates of semial mting were studied.
Some prelisinary observations have been made on what may be the cytology of this
mating process.

Further evidence has been accumlated for the localization of 2 provirus at a
specific locus of 2 chromosome in lysogenic F. coli. 4 transduction mechanism

has else been found in EF. coli, so thot the chromosomel basis of thie process

ean be verified,

VY. Publications that have appeared in print from July 1, 1952, to June 30, 1953:
Lederberg, J. Cavalli,LeLe, and Lederberg, FM, Sex compa tibiiity in Escherichia coli.
Genetics 37: 720, 1952 (Nov.)
Lederberg,i.iie, and Lederberg,J., Genetic aspects of lym genicity in Escherichia coli.
Genetics 36151, 1953 (dan.)
Cavalli,L.l., Lederberg,J., and Lederberg,E.i., An infective factor controlling
cont'd overleaf sex compatibility in Bacterium coli. Jour. Gen. Kicrubici. 8:89, 1953 (Feb.)

Zinder, N.D. and Lederberg,J., Genetic exchange in Salmonella. Jour. Bact.
64: 679, 1952 (Nov.)
Lederberg,d., Cell genetics and hereiitary symbicsis. Physicl. Revs. 32:403, tot
Oct.

VI. In press: Lederberg,J., Some biological aspects of bacterial genetics.
Proc, 2d Nat. Cancer Cong., Cincinnati, 1952, In Prase,

see over
The wink covy should be returned te the Graduste School Office on or before
August 1, 1953. The blue copy is for your Pile.
In Presa, cont'd:

Stocker ,B.A.D. $e» Zinder, N.D., and Lederberg,J., Transduction of flagellar
charac ters in Salmonella. Jour. Gen. Microbiol., In Press.

Lederberg,J. and Edwards, P.R., Serotypic Recombination in Salmonella.
Jour. Immunology, In Press.

Lederberg,J. and Tatum, E.L., Sex in bacteria: genetic studies 1945-1952.
A.A.A.S. Symposia, In Preas.

Cavalli, L.l., and Lederberg,J., Genstdie aspects of chemotherapy.
Symposiun on chemtherapy, IV Int. Gong. Weroblcology, Rome,1953, In Press.