No.

NATIONAL SCIENCE FOUNDATION ADVISORY COMMITTEE
BIOLOGICAL AND MEDICAL SCIENCES

PROPOSAL RATING SHEET

Title Investigator Institution

B~3081 Mutational origin of halophilic William L, Flannery Baylor U

Score

bacteria

The prppesal is for a problem of fundamental interest, doubtless having
been suggested by Allen's recent studies on tie mutational basta of thernc~
phily, The investigator appeearr te be semewhat neive as to the experiments
he proposes; to my mind, 2 preliminary survey to substantiate ths possibilities
should prececd any longer-term investment, The ideas ar: rather rote, end have
te be so long as as he has not actually initiated any genetic studies. The previeus

‘werk of Deudoroff wuggests, however, that several casplications will arise, the

rate of change of fonie strength possibly being as impertent a factor in bac-

Series survival as the salt cmoentration itself, Him I have had access to
‘Flanneryts review 4n press, which, together wifh his previeus peper's euggeat

@ wintler simple-utndednese of spprosch, Yevever, noone else appears to

ly te go inte this etory, and it aight be worthwhile te simply stir up sane
interest in this tapertent proble. T shoald think one could make & goed start
on this kind of werk with a minimm ef assistance and expense, though the budget
presented is not extravgant.

“2

_. _ Signature
From 5 (low) to 1 (high)