No.

B-30L,8

Score

NATIONAL SCIENCE FOUNDATION ADVISORY COMMITTEE
BIOLOGICAL AND MEDICAL SCIENCES

PROPOSAL RATING SHEET

Title Investigator Institution

Mathematical analysis of tetrad Carl C. Lindegren Southern 111 U
data from yeast genetics .

The mathematical formalization of oreesing~over is an impertent
research area that has ocoupled the attention of a variety of workers
(e.g., the very elaborate proposale of Oven and Sir Renald Fisher). A
hasty reading of Seult's analysis (to ubich T had access independeAitly
ef the SF, and whieh was not furnished with the application) leads me
to think thet he hes made en interesting advence in the applicetion of
a preup—~tieeretieal approach (a notion on vhieh I wnsuscersfully sought
te elicit sane mathematical interest in 1947) and he appears’ to have been
able to simplify end generalize seme derivations in tetrad theory, This
work should definitely be encouraged, and Scinlt seems rather ebright
lad, but I doubt that this is the right track. No theoretical development
that is goings to require expensive machine-——~programing is going to
be partieulably useful, and I suspect the theary isself has not yet been

The data that the Lindegrens hace sccwslated

be entirely feasible on a nore
modest basise after they have hed a preliainary survey ve could moaningfully
enquire whether they warrant the type ef analyais indicated here.

'g reputation and atanding have been reviewed in pfevicus
evhhuations, end I meed not repeat my previous remeris, It is characteristic
that he should ask for $800 travel for a stationary project.

I think enough ef Selult to vant te keep him in business, It is a
question I cennet snewer whether he would not be far better off in
mere rigorous surroundings; one recamendatéon I would be prepared to
consider would be a grant sufficient to subsidize his om salary, i.e.,
about 4500 altogether. ;

DW
From 5 Clow) to 1 (high)

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