clinical demonstre tions

Ae What is heredity
1, twins, Naters and norburs.
9, Collection and interpretation of family cata, Censan
Single factor inheritence. Dominance, Sex Linkess,
4. The chromosomes of man, Sex determination.

B. Common hereditary factors
lieS, Blood groups, Transfus
6, The hemoglobins AND here

ion, Hemorrhagic dissase of nowborn, Forensic.
diltary ancmiLas.

C, Rare maitants in man
7, Mutation, Metabolic diseases with physielogical genetics of Neurospera, ete. ,
as backeround, Phenylketemuric oligephrenias alkeptonuria; tyresincsis.
8, Metabolic discases, cid., glycogen storage disease: galactosomic hepatomegalys
agaumaplobulinemia; nemophilias, Metabolic Individuality.

D, Polygenic inheritance
9, Genetic factors in infectious and constitwtional disease; cancer.
10. Genetic factors in mentel disease,

E, Genetic hygiene
lL, Aims and fallacies of eugenics: social and “industzial” medical problens fron
vadiation (and chemicals?).

F, Experimental genetic studies on mammals
12. Example-~-histocompatibility and acquired tolerance; the antibody response.

G. Microbial genstics
13, Mutation studies, Drug resistance.
1h, Recombination mechanians,
15, Viruses (as crganisus and as genes).

love: This is a tentative outline of feasible topics, The syllabus would depend on
the judgment of the instructor.

Some of these topics may already be adequately cevered ‘in other course work, Pvery
effort should be made to correlate this with other offerings, It will be essential to
seek the cooperation of clinical specialiste i} for appropriate case demonstrations,
and 2) to ensure a balanced account of such topics as mental disease, eugenics and
radiation hazards, If there ave pronounced differences of opinion within the medical.
faculty, it may be profitable to arrange for joint presentations or discussions.

Student laboratory exercises would pose many problems, tus might be worked out in
collaboration with ether courses (clinical psatholosys physiological chemistry; micro=
blology).

Tt would be helpful to have some standardization of preparation in genetics. If
most prensdicel students will already heave included a course, it would be wise to urge
most of them te do soz 1f not, more emphasis may be necded on the bleod greupa

2
The cource is not designed to indoctrinate specialists, but to incricate an ape
preciation for the role of the genotic factor in the determination of disease amd of

normal personal individuality. With this background, the student may be better equip
ped to learn from his experience in the clinical years and his practice.

Text: Possibly "Harris- Intreductionte Human Biochemical Genetics"
Reference Books: Sorsby» Clinical Genetics; Neel and Shull- Human Hereditys
Sterm» Human Genetics

d, Lederberg