RESEARCH INSTITUTE FOR NUCLEAR MEDICINE AND BIOLOGY
HIROSHIMA UNIVERSITY
KASUMI-CHO, HIROSHIMA, JAPAN

April 4, 1969

Dr. Joshua Lederberg
Department of Genetics
School of Medicine

Stanford University

Palo Alto, California 94304
U.S. A.

Dear Sirs:

I hav¢ been looking for streptomycin-resistant mutants of
Escherichia coli K12, which have altered ribosomal components.

I got the streptomycin-resistant strain W3637 from Dr. Hino of
Hiroshima University, who had got it from Dr. Y. Hirota.

And this strain seems to have some alteration compared to non-

resistant Kl2 strain on carboxy-methyl-cellulose column chromatography
of ribosomal proteins.

I want to know how, from what strain and by whom this W3637
strain was derived. I would be very glad if you give me informations
about these things or about reference paper published, and send me
the original strain of W3637, which has not streptomycin- resistant

mutation.

Sincerely yours,

Pabsth, JokaDp

Renkichi TAKATA Ph.D.

Research Institute for Nuclear

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