55.

56.

57,

58,

Woods, Roy and Herzenbera, Leonard A.
Specificities common to mouse IgG and IgA molecules.
(In preparation).

Lanzerotti, Richard M. and Herzenberg, Leonard A,
Population of antibodies recognizing distinct allotypic specificities
in mouse immunoalobulin. V.

- (In preparation).

Herzenbera, Leonard A., Pernis, B., and Kelus, A.S.

A second locus controlling rebbit heavy chain allotypes on the
Fd fragment of a second-class of immunoglobulin.

(In preparation).

Herzenberg, Leonard A., Carbonara, A., Tosi, Res and Pernis, B.
Comparison of a locus allotypic specificities, in IgG, IgA, and
IgM in the rabbit.

P~ 20!
— -f O- nating

 

 

 

 

 

 

 

 

 

 

 

 

Geetha sare tet nO aD tat etMane Nite oa cp 2, Beparias ant ae Pre oboe “ }
- Se ee ete feateted sO ce PD te ee |
NAME TITLE BINTHOATE Wa, cur, ree |
H. Russell Hulett Research Associate May 5, .1926
PLACE OF DIATH (Cety, State, Country} PRESENT NATIONALITY Uf nen-U.S crtteun, SEK
indicate kind of visa and expiration date}
Nespelem, Washington U.S.
. Sry Mate Pl Eemse
EDUCATION (Begin with baccalauresio traimng and inctuda pasidoctorai) :
INSTITUTION ANO LOCATION “¢ YEAR SCIENTIFIC
DEGREE CONFERREO FIELO
. - '
Oregon State College, Corvallis, Ore. B.S. 1941 a
Oregon State College, Corvallis, Ore. M.S. 1942 ~
Stanford University, Stanford, Cal. Ph.D. 1964 Chemistry
, . |
KONORS Meémpersnip ins
Phi Lambda Upsilon . m
Pi Mu Upsilon + |
Sigma Xi .
MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT

ft

Instrumentation development, investigzac.

Biomedical instrumentation, origin of life. | te 1 :
of svecific cell sevarations, evalus -

 

RESEARCH SUPPORT (See sasiructuons)

N/A

 

RESEARCH ANDAOA PAODFESSIONAL EXPERIENCE (Starting with present position, Ext sca'2ng eng expenence rerevant to area Sharojesse biz
Or most representative sudlcations Oo not exceed 2 pages for each indiwidual.}
1966 - present: Research Associate, Stanford University
1964 ~ 1968: Associate Professor, Head,Department of Chemistry, College of Notre can
1965 ~ 1966: Department Head, Itek Corporation . .
1959 ~ 1964: Researcn Director, Advanced Technology Labs
1957 ~- 1959: Subsystem Manager, Lockheed

1952 - 1957: Electronics Department Eead, Detroit Controls

1951 = 1952: Electronics Department Head, Santa Barbara Research
1946 - 1951: Eleccronic Engineer, Hughes Aircraft

1942 - 1946:- U. S. Arny ; .

Publications: (selected ~~ since 1965)

Hulett, H. R. and H. S: Loring. "Reactions of metals with tobacco mosaic virus."
Federation Proceedings. 23:1943 (1965)
Hulett, H. R. and H. S. Loring. "Effect of particle length distribution on infec-
tivity of tobacco mosaic virus." Virology 25:418 (1965)
Hulett, H. R. "Turbulence limitations in photographic resolution of planet
‘surfaces."" J. Opt. Soc. Am. 57:1335 (1967) .
Ehrlich, P. and H. R. Hulett. “Living on capital.” New Scientist 38:426
Hulett, H. 2. "Limitations on prebiolozical synthesis." J. Theor. Biol. --:
Huletc, H. R., Bonner, W. A., Barrett, J. and L. A. Herzenberg. "Cell sarc
automated separation of mammalian cells as a function of intracellular
fluorescence." Science 166: 747-749 (1969)
BHS-J98 5
flev. 3-70 : page . P-2O%
DO NOT TYPE IN THIS SPACE-BINDING MARGIN

 

Hulett, H. R. “Optimum world population." Bioscience. 20:160 (1970)
Hulett, H. R. "Non-enzymatic hydrolysis of adenosine phosphates." Nature
225:1248 (1970 : . | | |
Hulett, H.°R., Coukell, A., and W. Bodmer. "Tissue typing instrumentation using
the fluorochromatic cytotoxicity assay." Transplantation 10:135 (1970).
Hulett, H. R. and L. A. Herzenberg. "Approaches to prescreening with
special consideration of flow systems." Acta Cytologica (in press)
Hulett, H. R. and L. A. Herzenberg, W. Bonner and R. L. Wolf. "Rapid cell
sorter -- a néw tool for cell study with clinical appliations.”
Laboratory Investigations 22:501 (19.70).
Hulett, H. R. “Shock-synthesis of amino acids in simulated primitive atmosphere."

Science 170#1000 (1970). Letter to the Editor.
Seven patents on electro-optical devices and instrumentation

Publications after 1970:

Merrill, J. T., N. Veizades, H. R. Hulett, P. L. Wolf and L. A. Herzenberg.

"An Improved Cell Volume Analyzer" Rev. Sci. Instr. 42, No. 8, 1157-1163 (1971).

Bonner, W. A., H. R. Hulett, R. G. Sweet, and L. A. Herzenberg.

"Pluorescent Cell Sorting" Rev. Sci. Instr. 43, 404 (1972).

Hulett, H. R., R. G. Sweet, L. A. Herzenberg. ‘Development and Ap- lication of
Rapid Cell Sorter," to-be presented at 0.R.N.L. symposium on Advanced
Analytical Methods for the Clinical Laboratory, Mar. 15, 1973 (and later
published in Clinical Chemistry.)

Hulett, H. R. "Formaldehyde and Ammonia as Precursors to Prebiotic Amino Acids.
Science 174, 1038, 1971. .

 

Poge 15 STuscro 1070 - 79
P-203.
— — : ; — - = 34 ’ TT ci. a we Le €

BIOGRAPHICAL SKETCH Cenatinant of 2 cae

{Give the following information for all profectian2! rorsannel listed on p2ge 3, beginning with the Principal’ Investiqat of,
Use continuation pozes and foilaw the same general format for each person.)

 

 

 

 

NAME TITLE . BIRTHDATE (ito., Day, Yr)

John D. Johnson Assistant Professor September 14, .1932

PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY if non-U.S, citizen, SEX —_
indicate kind of visa end expiration date) ;

Palo Alto, California . U.S.A. KXwate  Clremie

 

EDUCATION (Begin with baccataurcate training and include postdoctoral}

 

 

 

 

 

YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERAED FIELD
Wabash College, Crawfordsville, Ind. B.A. 1960 _Zoology ::
Stanford Medical School, Stanford, Calif.| M.D. } 1965 _ Medicine
Johns Hopkins Hospital, Baltimore, Md. ' 1965-67 Pediatries,2 yea
Stanford Medical School, Stanford, Calif. . 1970 Post-Doctoral Fe
. erry 2: warres =

 

PUVCNUPe <7

. HONORS
Phi Beta Kappa, Alpha Omega Alpha, Borden Award for Undergraduate Research (Stanford
Medical School)

 

 

MAJOR RESEARCH INTEREST . ROLE IN PROPOSED PROJECT
Developmental Biochemistry,
bilirubin metabolisn Investigator

 

RESEARCH SUPPORT (See instructions)

United Cerebral Palsy Associations, Inc. Grant R-245-71,

Developmental Aspects of Heme Protein Catabolism ~
Current $28,772. July 1, 1971 to June 30, 1973 Total $53,322.

 

RESEARCH ANO/OR PR: FESSIONAL EXPERIENCE (Stertinag with present position, list training and experience relevant to erea Ghprojscs Liste
or most representative publications, Do not excced 3 peges far cech individvel.}
-- 1971 to present - Assistant Professor of Pediatrics, Stanford University

1971 to present - Assistant Director of Newborn Service, Stanford University

1970 - Post-Doctoral Fellow, Department of Pediatrics, Stanfora University
1967 -- 1969 - Research Associate, NICHD -

1960 - 1963 ~ Pre-Doctoral Fellow, Department of Pediatrics, Stanford University
Publications

Johnson, J.D., Hurwitz, R., and Kretchmer, N.: Utilization of fat and glycerol for
glycogenesis by the neonatal rat. J. Nutrition, 101, 299, 1971.

Johnson, J.D., Jant, B.A., Kaufman, S., and Sokoloff, L.: Effect of tonic strength
on the RNA polynezase activities of isolated nuclei and nucleoli of rat liver.
Arch, Biochem. Biophys., 142, 489, 1971.

Johnson, J.D., Christiansen, R.O., and Kretchmer, N.: Lactose synthetase in ma
gland of the California Sea Lion. Biochem. Biophys. Res. Comm. 47, 393, 1972.

Johnson, J.D., Albritton, W.L., and Sunshine, P.: Hyperammonemia accompanying parenterc
nutrition in newborn infants. J. Pediatrics @1, 154, 1972.

Johnson, J.D.: Neutrel hetero: --galactosidase fren the small intestine of the rabbit.
Submitted for publication to Biochim. Biophys. Acta.

P~20Y

RHS.-2

few

re
x a
SECTION I! — PRIVILEGED COMMU NICATION Denenm et ae tine
BIOGRAPHICAL SKETCH

(Give the following information for all professional personnel listed on p2ge 3, beginning with the Principal Investigator.
Use continuation p2ges and follavs the same generel format for cach person.}

 

 

 

 

 

 

NAME TITLE BIRTHDATE [ifc., Day, Yr)
Assistant Professor of April 27, 1939
Judith P. Koehler, M.D. Neurology and Pediatrics P ;
PLACE OF BIRTH (City, State, Country] PRESENT NATIONALITY f/f non-U.S citizen, SEX
indicate kind of visa and expiration date,
New York, New York piration date]
U.S. Citizen CD Mate KI] Femste
EDUCATION (Begin with baccalaureate training and include postdoctoral)
YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERRED FIELD -

 

Mount Holyoke College A.B. 1960
Dartmouth Medical School ‘B.M.S. . 1962
University of Pennsylvania M.D. 1966

 

 

 

 

HONORS

American Academy of Neurology (Junior Member)

 

MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT

Pediatr.- Neurology

 

 

RESEARCH SUPPORT (See instructions)

 

RESEARCH AND/OR PROFESSIONAL E XPERIENCE (Starting with present position, list training and experience relevant to area of project Lista.
or most representative publications, Do not exceed 3 pages for each individual.)

1966-1967 Intern, Mixed Pediatrics, Montefiore Hospital and Medical Center, Bronx, N.Y.

1967-1968 Junior Resident, Neurology, Albert Einstein College Hospital and Bronx Municipal Eos

1968-1970 Senior Resident, Neurology, Albert Einstein College Hosp. and Bronx Municipal /
Hospital Center, New York.

1969-1971 Postdoctoral Fellow, Anatomy, College of Physicians and Surgeons, Columbia Univ., %.

1971-1972 Fellow in Pediatric Neurology, Columbia-Presbyterian Medical Center, N.Y.

1972- Assistant Professor of Neurology and Pediatrics, Stanford Medical Center.

Publications (selected):

Koehler, J.P., Lovelace, R.E., Spiro, A.J.: Basement membrane and capillary endothelial altara-
tions in hypokalemic periodic paralysis: an electron microscopic study. (Abstract) Presente<
at the American Association of Neuropathologists, 47th Annual Meeting, June 1971.

Koehler, J.P., Spiro, A.J., Lovelace, R.E.: I. Thyrotoxic periodic paralysis: light and electre
microscopic observations of nerve and muscle. (In preparation).

Koehler, J.P. and Chuzorian, A.: Tissue culture of medulloblastoma cells from spinal fluid, a
useful diagnostic technique. “tn preparation). :
Spiro, A.J., Koehler, J.P., Taylor,.J.M.: Oculopharyngeal dystrophy: ultrastructural and histc-
chemical observations of skeletal muscle. (Abstract) Presented at the American Associatio:

of Neuropathologists, June 1972.

Koehler, J.P., Duffy, P.E., Carter, S. (1973) Selective type I fiber atrophy in childhood
neuropathy: light and electron microscopic observations of peripheral nerve, Schwann cells,
neuromuscular junction, and muscle. (In preparation).

 

RHS-398 ae
Rev. 3-70 . fe 20>

 
BIOGRAPHICAL SKETCH wes
(Give the foliowing information for ail profecsionst persennel listed on pve 3, beginning vith the Principal in YSHtOn
Use continuation pages eng follew the sime general format for each person.)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

a eretehmer oe Harold kK. Faber Professor CIRTHOATE (:2,, Coy, Ye).
of Pediatrics January 20,.1923
PLACE OF GIHTH (City, State, Country) PRESENT NATIONALITY (/f non-US citizen, SEX
: York N y . indicate kind of visa and expiration date}
ow nes U.S.A. §:] Mate C) Ferme
EDUCATION (Begin wita beecelaureate trainins and include pesidoctoral)
YEAR SCIENTIFI
INSTITUTION AND LOCATION | DEGREE CONFERRED FIELD c |
Cornell University ; . B.S. 1944 Anim al Phys iolocs
University of Minnesota ; M.S. 1945 Physiological Chen.
University of Minnesota | . ‘| Ph.D. 1947 Physiological Cher.
Downstate Medical Center, State Univ. of
LD. 1952
HOWORS Commonwealth ‘Fund Fellow, 1952,57,65 President, Int. Organ. Stucy Human Deveis
-Mead Johnson Award, 1958; ment, 1969; President, Soc.Ped.Res., i962:
- Borden Award, 1969 Council, Amer. Soc. Clin. Invest., 1964-5: -
Alumni Medallion SUNY, 1969.
MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT
Investigator
RESEARCH CUGPORT (Sze insirectians)
RR 81 - Clinical Research Center for Premature Infants, 10/1/69- 9/30/74
Amount current year: 418,532 - Total amount: 2,021.3C0- (5%) renewal fending
HD 02147 - Biochemical Studies of Developzent, 6/1/66- 5/30/73,
Amount current year: 206,593 - Total amount: 1,309,278- (15%) renew pendin:.
CRBS 252 - National Foundation ~ Cellular and} Molecular Determinants of aller Aaa A
Amount current year: $27,273 - Total amount: 54,546 (7/1/71-6/30/73)- (25%) -
HD 00049 -' Human Development and Pediatrics Training Grant, 7/1/70-6/30/74,
Amount current year: $90,588 - Total amount: 448,936.- (10%)reneval pending
(Please see continuation on attached sheet)
RESEARCH ANOJOR PROFESSIONAL CXFE RIENCE (Sterling wit presert position, st training anu eaperiense relevent ta arca of project List
or most representative pubucations, Da net exceed 3 payes lor exch individual)
1971 to present - Harold kK. Faber Professor of Pediatrics
1969.-.1972. .~ Chairman, Program-in Euman Biology (Baccalaureate Prog., Stanford Uri
1959 - 1969 - Professor and Executive Hcad, Pediatrics
1953 - 1959 - Assistant then Associate Professor, Dept. of Peds, Cornell Uriv.
~ 4 New York Fospital
1950 ~.1955 - Lecturer, Department of Biology, Brooklyn College -
1948 - 1952 ~- Research Associate, Dept. of Pathol., State Univ. of New York
1947 - 1948 - Assistant Professor, Departments of Pathology and Biocheristry, Univ.
of Vermont,
From 1952 - Various clinical appointments fron Intern to Pediatrician-in-Chief

Publications (Six relevant publications are listed from a total of 101)

os

Kretchner, N.: Lactose and lactase: A historical perspective. Gastrceenterolosy sl EO
1971,
Levine, R.L., Hoogenraad, N.J., and Kretchmer, N.: Regulation of activity of carb anyl-
phosphate synthetase from mouse spleen. Biochemistry 10:3694, 1971
Lebenthal, F., Sunshine, P., and Kretchmer, N.: Effect of carbohyrate and
corticosteroids on activity of d-glucosidases in ircesrine of the
. ‘ infant rat. J. Clin. Invest. 51:1244, 1972.

Kretchmer, N., Ransome-Kuti, 0., Hurwitz, R., Dungy, C., and Alakija, W.:
Intestinal absorption of Jactose in Nigerian ethnic groups.
The Lancet 2:392, 1971.

 

 
Biographical Sketch of Dr. Norman Kretchmer

Page Two

Research Support, continued

HD 00391 - Regulation of enzyme ‘action during development,
9/1/68-8/31/73 .
‘Amount current year: 42,289 - total amount: 183,822 (15%)

Publications, continued

Weichsel, M.E., Jr., Hoogenraad, N.J., Levine, R.L., and Kretchmer, N.
Pyrimidine biosynthesis during development of rat cerebellum
Pediatric Res. 6:682, 1972.

Johnson, J.D., Christiansen, R.O., and Kretchmer, N. Lactose synthetase
in mammary gland of the California sea lion. Biochem. Biophys.
Res. Commun. 47:393, 1972.

Note: Renewal of HD-02147 is pending. This present renewal application,
HD 00391, in part overlaps with sone material included in HD-02147,
SECTION PRIVILEGED COMMUNICATION . Tacertmant ab Aeneas
APPLICATION NUMER (fesce blank; '

 

BIOGRAPHICAL SKETCH
(Give the following informotion for each KEY professional staff member, whether or nat salary is requested. Begin with the
Progrom Director.)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

NAME (Last, first, initial) tEProfessor of Pediatrics and BIRTHOATE (.My., Dap. Yr.)
. : Community & Preventive Medicine 9/6/14
Luigi Luzzatti, M.D. Sex
PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (If non-US. citizen, indicate MR mate —- 7) Female
visa symbol) SOC. SEC. NO.
Rome, Italy U.S. Citizen §70-42-7539
RELATIONSHIP TO PROPOSED PROGRAM
Investigator
EDUCATION (Begin with baccalaureate training aud include postdoctoral)
ORGANIZATION ANO LOCATION DEGREE YEAR DISCIPUNE
CONFERRED
University of Minnesota, Mpls, Minn. M.S. [1942
University of Minnesota, Mpls, Minn. M.D. $1943
%
HONORS

 

MAJOR RESARCH OR PROFESSIONAL INTEREST 1 lf applicuble)

Congenital Defects and Cytogenetics

 

UST RECENT RELEVANT PUBLICATIONS

Miles, C.P., Luzzatti, L., Storey, S. and Peterson, C.D.: A male pseudo-
hermaphrodite with a probable XO/XY¥ mosaicism. Lancet, Sept. l, 1962, 455.

Luzzatti, L.: Failure to thrive - a diagnostic approach. Postgrad. Med.
35:270-8, March 1964.

Peterson, C.D. and Luzzatti, L.: The role of chromosome translocation in the
recurrence risk of Down's syndrome. Pediat. 35:463-9,-March 1965.

4

Weichsel, M.E., Jr., and Luzzatti, L.: Trisomy 17-18 syndrome with congenital extrahepa

biliary atresia and congenital amputation of the left foot. J. Ped, 67:324-7, Aug.
PROFESSIONAL AND/OR RESEARCH EXPERIENCE (Start with present position und list recent significant experience relevant to program } (pub lications cont.

2
3

1972- Professor of Pediatrics & Community and Preventive Medicine
1967- Director, Birth Defects Center, Stanford Univ. School of Medicine
1963- Director, Cytogenetic Lab., Stanford Univ. School of Medicine

1957-72 Associate Prof. of Pédiatrics and Preventive Medicine, Stanford Univ. Sch. of ™q
1955-67 Director, Pediatric Outpatient Dept., Stanford Univ. School of Medicine
1954-57 Assistant Prof. of Pediatrics and Preventive Medicine, Stanford Univ. Sch. of =.
1953-54 Director of Cerebral Palsy Training Program, Children's Hospital of

San Francisco

 

 

 

PHS 2499-1 PAGE
Rev. 3-70 U.8. GOVERNMENT PRINTING OFFICE : 1970 OF - 366-486

—
PI, wire.
Bopercicnt af Seon ts

Publications (continued)

Craig, A., and Luzzatti, L.: Translocation in De Lange's syndrome? Lancet 2:445-6,
August 1965.

Craig, A., and Luzzatti L.: Translocation in trisomy D syndrome. A case of
probable D/18 translocation. J. Pediat. 70:264-9, Feb. 1967.

Greenstein, R.M., Harris, D.J., Luzzatti, L. and Cann, H.M.: Cytogenetic
analysis of a boy with the XXXY syndrome: origin of the X-chromosomes.
Pediatrics, 45:677-686, April 1970.

Knight, L., Sakaguchi, S., and Luzzatti, L.: Unusual mechanism of transmission
of a chromosome translocation from mother to offspring. American J. Dis.
of Children 121:162-167. Feb. 1971.

Knight, L., and Luzzatti, L.: Replication patterns of X & Y chromosomes in
partially synchronized human lymphocyte cultures. Chromosoma, Vol. 40,
153-166, 1973.

P-209
Licereeeee eS

 

 

 

 

 

 

 

 

 

 

 

 

slots . Dole ge a Le tt WIP LE Pale eG aire.
Us2 continust:o¢ 3itss 27d! Poifaey oss ome seneral format for 2eac4 geren.;
NAME TITLE BIRTHDATE f’2., Cay, rr.)
Wilfred E, PEREIRA Research Associate June 23 1976
PLACE OF BIATH (City, Stace, County] PRESENT NATIONALITY UF non-US. citizen, SEX
iagicete kind o visz and exsirauon date}
. ndian, Permanent Resident
Madras, S. India Irmierant Vise Eel Male C2 femare
EDUCATION (Sern etn baecalaure3it2 training eng intiudes costdector2"}
YEAS SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERRED FIELD
Madras Medical College, Madras, India | B. Pharm 1960 Pharmaceuticea. Chenistry
Saugar Univ, Madhya Pradesh, India. M. Pharm. 1962 Pharm. Chem & Chem of Nat
U.C. Med. Center, San Francisco, Calif | Ph.D. 1968 Pharm. Chem & Pharmactolos
HONORS
MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT
Identification of Metabolites & drug
metabolites in Bzrolosical fluids ‘Organic chemist

 

 

RESEARCH SUPPORT (See instrecuans)

 

RESEARCH ANO.CR FFCFESSIONAL EXPERIENC Ig7tIP vith Orzeen: rosiWon, tise teaming and expererce rerivant io area Qforsj;es. Ut se

ormos represen iaive Bes ieauors, Ga not exces 352 res! for 2307 re ee
1905 - 1970 Fost Ceetoral Felicw, cept. of Genetics Stanford Universit Med. School
1970 = oresent Research Asscciate sare insticution -

During these four years I have teen involved with reptide synthesis, amino acic analysis
and synthetic Organi ¢ chemistry. I heired develop methods for the separation of

diasterioisomers ty cas chromatoerazhy and nav been involved with the routine us
‘eas chromatography sass spectrometry for the entification of urinary metabolite
and patholosical urine and serum sanples. Ky pplications of mass spectrometry h
included the deveciprment of mass frasmentosraphy for the determination of the air a
contents of soil and xkxxxxx serum. ‘My present project involves the screenings of urine
from leukemic patients for atnormal metabolites and to investigate the metabolic fate of

anti-leukemic chemotheropeutic egents in the body.
PUBLICATION

1. Transesterificeation with an Anion-exchange Resin;
W. Pereira, V. Close, W. Patton and B. Halpern,

J. Org. Chen. 34:2032 (1 959).

Bir p A 7

2. Alcoholysis of the Merrifield-type Peptide-polymer Bond with an Anion

Exchange Resin;
W. Pereira, V. A. Close, E. Jellun, W,. Patton and 3. Halpern,

Australian J. of Chem, 22:1337 (1909).

hess
Rev, 3-70
3.

h,

Se

6.

Te

8.

9.

10.

The Action of Mitrosyl Cnlorice cn Faenylalanine Peptides;
W. Patton, ©. Jellum, D. Nitecni, W. Pereira and B, Halpern,

‘Australian J. of Chem. 22:2709 (1969).

Abnormal Circular Dichroism of 4 -Amino Acid Esters;
J. Cynerman Craig and W. E. Pereira,
Tet. Let. 18:1563 (1970).

The Use of (+)-2,22-Trifluoro-l-Phenvlethylhydrazine in the Optical
Analysis of Asymmetric Ketones ty Gas Chromatography;

W. E. Pereira, M. Solomon and 8. Halpern,

Australian J. of Chem.24:1103 (1971).

The Microsomal Oxygenation of Ethyl Benzene. Isotopic, Stereochenical,

and Induction Studies;
R. E, McMahon, H. R. Sullivan, J. Cymerman Craig end W. E. Pereira,

Arch, Biochen. Biophys. 132:575 (1969).

The Steric Analysis of Alirhatic Amines with Two Asymmetric Centers
by Gas-liauid Chromatography of Diastereoiscreric Andes.

W. E. Pereira and 3. Ealrern,

Australian J. Chen. 25:667 (1972).

Optical Rotatory Disrersion and Absolute Configuration -XVII,

QA-Alkylvhenylacetic Acids;
J, Cymerran Craiz, W. £. Pereira, B. Halpern and J. W. Westley,
Tetrahedron 27:1173 (1972).

The Optical Rotary Disrersion and Cire dar Dichroism of A-Amino and
A-Hydroxy Acics;

J. Cymerzmen Craig end W. E. Pereira

Tetrahedron 26:3457 (1970) . -

The Determination of Cyclohexylamine in Aqueous Solutions of Sodium
Cyclerate by Electron-capture Cas Chromatography;

M. D. Solozon, W. 2. Pereira and A. M. Duffield,

Anal, Let. 4:301 (1971),

Pr2l
12.

13.

14,

15.
16.
iT.
18.

19.

20.

Chlorination Studies. I. The Reaction of Aqueous Hypochlorous Acid
with Cytosines accn

W. Patton, V. Brown, A. M. Duffield, B. Halpern, Y. Hoyano, W. Pereira
and J. Lederberg,

Biochem, Biophys. Res. Commun, 48:880 (1972).

The Use of R-(+)~-1-Phenylethylisocyanate in the Optical Analysis of
Asymmetric Secondary Alcohols by Gas Chromatography;
W. Pereira, V. A. Bacon, W. Patton, B. Halpern, and G. E. Pollock,

Anal. Let. 3:23 (1970).

A Rapid and Quantitative Gas Chromatographic Analysis for Phenylelenine

in Serum;
B,. Halpern, W. ©. Pereira, M. D. Solomon and E, Steed,

Anal, Biochem. 39:156 (1971).

Electron-irpact Promoted Fragmentation of Alkyl-"~(1-Phenylethyl)-
Carbamates of Primary, Secondary and Tertiary Alcohols;

W. E. Pereira, B. Halpern, M. D. Solomon and A. M. Duffield,

Org. Mass Spectrometry 5:157 (197%).

Peptide Ses quencing by Low Resolution Mass Spectrometry}
V. Bacon, £. Jellun, W. Patton, Ww. Fereira end B, Halpern,
Biochem. Biophys. Res. Commun. 37:878 (1969).

A Ges Liquid Chromatographic Method for the Determination of Phenylalanine

in Serur;
E, Jellun, V. A. Close, W. Patton, W. Pereira and B. Halpern,

Anal. Biochen, 31:227 (1959),

Quantitetive Determination of Biologically Inportant Thiols and
Disulfides by Gas Liquid CHrOTATOgTEPhy 4

E. Jellun, W. Patton, V. A. Bacon, We E. Pereira and B. Halpern,
Anal. Biochem. 31;339 (1969). -

A Study of the Electron Inpact-prezoted Frasmentation of Pree ezine
Sulfoxide and Prozazine Using Specifically Deuterated Analogues;
M. D. Solomen, 2. Sumzons, W, Pereira end A. M. Duffield,

pr

Australian J. Chem. (1973, in ess).

The Determination of Phenylelenine in Serum by Mass Fraczentography;
W. Pereira, V. A. Bacon, Y. Eoyano, R. Sumrons and A. M. Duffield,
Clin, Biochem. (In press).

Chlorination Studies II. The Reaction of Aqueous Hypochlorous Acid

with %-Amino Acids and Direptices;
W. E. Pereira, Y. Hoyano, R. Summons, V. A. Bacon and A. M. Duffield,

Biochem. et Biophys. Acte (In press),
r , (126)
"| SECTION I! — PRIVILEGED COMMUNICATION
BIOGRAPHICAL SKETCH

{Give the following information for al! professional personnel listed on pege 2, beginning with the Principel Investigetor.
Use continuation peges and follow the same general format for eech perton.}

 

 

 

 

 

 

 

 

 

 

 

 

NAME TITLE BIRTHDATE (Ma,, Dey, Yr.)
Thomas C. Rindfleisch Research Associate , 12-10-41
PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (/f non-U.S, citizen, SEX
indicate kind of visa and expiration date)
Oshkosh, Wisconsin, USA USA 4 Male) Femete
EDUCATION (Begin with baccalaureste training and include postdoctoral]
YEAA SCIENTIFIC
INSTITUTION ANO LOCATION DEGREE CONFEARED FIELD
Purdue University, Lafayette, Ind. B.S 1962 Physics
California Institute of Technology, M.S 1965 Physics
Pasadena, CA Ph.D Thesis to bq completed. All
course work iand examinations
completed.
HONORS :
Purdue University, Graduated with Highest Honors, Sigma
Xi.
MAJOR RESEARCH INTEREST ROLE IN PROPOSEO PROJECT
Space sciences, computer science and
image processing Technical Support

 

UPPORT (See instructions)

 

RESEARCH ANO/OR PROFESSIONAL E XPERIENCE (Starting with present position, list training end experience relevant to area of project. List all
or most representative publications, Do not exceed 3 pages for each individual.) .

1971-Present Stanford University Medical School, Department of Genetics,

Stanford, CA.
Research Associate ~ Mass Spectrometry, Instrumentation research.

1962-1971 Jet Propulsion Laboratory, California Institute of Technology,
, Pasadena, CA.

Relevant Experience:

1969-1971: Supervisor of Image Processing Development and
Applications Group.

1968-1969: Mariner Mars 1969 Cognizant Engineer for Image
Processing

1962-1968: Engineer - design and implement image processing
computer software.

1. Rindfleisch, T. and Willingham, D., "A Figure of Merit Measuring Picture
Resolution,'' JPL Technical Report 32-666, September 1, 1965.

2. Rindfleisch, T. and Willingham, D., “A Figure of Merit Measuring Picture
Resolution," Advances in Electronics and Electron Physics, Volume 22A,
Photo-Electronic Image Devices, Academic Press, 1966. ,

 

RHE . P-2/3

 
Thomas C. Rindfleisch
PUBLICATIONS (cont'd)

3. Rindfleisch, T., "A Photometric Method for Deriving Lunar Topographic
Information," JPL Technical Report 32-786, September 15, 1965.

4. Rindfleisch, T., "Photometric Method for Lunar Topography," Photo-
grammetric Engineering, March 1966.

5. Rindfleisch, T., "Generalizations and Limitations of Photoclinometry,"
JPL Space Science Summary Volume III, 1967. '

6. Rindfleisch, T., "The Digital Removal of Noise from Imagery," JPL Space
Science Summary 37-62 Volume III, 1970.

7. Rindfleisch, T., "Digital Image Processing for the Rectification of
Television Camera Distortions," Astronomical Use of Television-Type
Image Sensors, NASA Special Publication SP-256, 1971.

8. Rindfleisch, T., Dunne, J., Frieden, H., Stromberg, W., and Ruiz, R.,
"Digital Processing of the Mariner 6 and 7 Pictures,” Journal of
Geophysical Research, Volume 76, Number 2, January 1971.

9, Rindfleisch, T., "Digital Image Processing," To be published, IEEE
Special Issue, July 1972. '

P-21y4
Prof. §. Le2ertorg
SECTION Il — PRIVILEGED COMMUNICATION . Cepartment cf Ceretic:
BIOGRAPHICAL SKETCH

{Give the following information for all professional personnel listed on page 3, beginning with the Principal Investigater.
Use continuation p2ycs and foilovs the same general format for each person, )

 

 

 

 

 

 

 

 

 

 

 

NAME TITLE : BIRTHDATE (740., Bay, ¥r)
Professor and Chairman
Schulman, Irving Department of Pediatrics 2/17/22
PLACE OF BIRTH (City, State, Country) PRESEWT NATIONALITY (/f non-U.S. citizen, SEX
indicate kind of visa end expiration date}
New York City, New York U.S.A. mate Ci Femate
EDUCATION (Begin with beccelaureate training and includ: postdoctoral}
' - YEAR SCIENTIFIC
INSTITUTION AND LOCATION ; DEGREE CONFERRED FIELD
New York University, New York °
New York University College of Medicine, B.A. 1942
New York M.D. 1945
HONORS

Phi Beta Kappa, Alpha Omega Alpha
Mead Johnson Award for Pediatric Research, 1960
President, Society for Pediatric Research, 1966

 

MAJOR RESEARCH INTEREST HOLE IN PROPOSED PROJECT
Coagulation physiology, Hemorrhagic dis-
eases

 

 

RESEARCH SUPPORT (See instructions)

See next’ page

 

RESEARCH AND/UR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevant to area of project: List aii
or most representative publications, Oo not exceed 3 pages for each individual.)

Professor and Chairman, Dept. of Pediatrics, Stanford University- 1972
Professor aad Head, Dept. of Pediatrics, University of Illinois - 1961 - 1972
Professor of Pediatrics, Northwestern University - 1958-1961

Associate Professor of Pediatrics, Cornell University - 1956-1958

Assistant Professor of Pediatrics, Cornell University - 1952-1956

USPHS Post-Doctoral Fellow in Pediatrics, Cornell University -~ 1950-1952
Resident in Pediatrics, Bellevue Hospital -1948-1950

Military Service ~ 1946-1948 —

Intern, Queens General Hospital, New York City - 1945-1946

P-2is-
Pref, 3. Lezerbers

Lepertrcnt cf Sere oc

Privileged Communication - Irving Schulman, M. D.

Biographical Sketch (continued)

Research Support

HD-00568~12

HD-07300-01

TI-AN-05344

Hemostasis and Hemorrhagic Disease in Children

Principal Investigator 20% time

Project period 1/1/70 - 12/31/72
Total Funds ; (Direct) $122,993
Current Year (Direct) $ 15,814 1/1/72 - 5/31/72

University of Illinois

eoccan $27,426 6/1/72 ~- 8/31/72
Stanford University

Training Grant in Pediatric Hematology

Program Director 20% time
Period 7/1/67 - 6/30/72
Total Funds $263,465
Current Year $ 54,458

*Training grant renewed at University of Illinois for
five years effective 7/1/72 ($332,600)- application

for new training grant in Pediatric Hematology has been
submitted from Stanford University.

P-2tb
Prof. J. Lentz

Privileged Comunication - Irving Schulman, M. D. Depariieni of Cinesct

5.

6.

8.

9.

10.

ll.

Representative Bibliography
Irving Schulman, N.D.
(Past 5 Years)

Abildgaard, C.F., Corrigan, J.J., Seeler, R.A., Simone, j.V., and
Schulman, I.: Meningoccemia associated with intravascular coagulation.
Pediatrics 40:78, 1968

Johnson, C.A., Abildgaard; C.F., and Schulman, I.: Coagulation studies
in children with cyanotic congenital heart disease. Lancet 2:660, 1968

Seeler, R.A., Forman, E.N., Bolger, J.F., Abildgaard, C.F., and

Schulman, I.: Induction of intravascular coagulation and renal cortical
necrosis in rabbits by simultaneous injection of thorotrast and endotoxin.
Brit. J. Haemat. 16:501, 1969.

Forman, E.N., Abildgaard, C.F., Bolger, J.F., Johnson, C.A., and Schulinen,I.:
Generalized Shwartzmen reaction: Role of the granulocyte in intravascular
coagulation and renal cortical xecrosis. Brit. J. Haermat. 16:507, 1969.

Honig, G.R., Forman, E.N., Johnson, C.A., Seeler, R.A., Abildgaard, C.F.,
and Schulman, I.: Administration of single doses of AHF (Factor Vil)
concentrates in the treattient of hemophilic hemarthroses. Pediatrics
43:26, 1969.

Honig, G.R., Abildgaard, C. F., Forman, E.N., Gotoff, S.P., Lindley, A.,
and Schulnan, I.: Some properties of the anticoagulant factor oF eased
pooled plasma. Thrombosis et Diathesis Haemorrhagic 22:151, 1969.

Schulman, I., Abildgaard, C. F., Johnson, C. A. and Lindley, A.t Imune-
suppressive therapy in the management of acquired inhibitors of Factor VIIi
in hemophilia. Hemophilia and New Hemorrhagic States (Brirlkhous, editer),
New York, The University of North Carolina Press, 1970, p.164.

Johnson, C.A., Abildgaard, C.F., and Schulnan, T.: Functional studies of
young versus old platelets in a patient with chronic thrombocytopenia.
Blood 37:163, 1971.

-

N,
x

Corby, D.G., Zirbel, C.L., and Schulman, I.: Thrombasthenia. Am. J. Dis.
Child. 121:40, 1971.

Corby, D.G., Zirbel, C.L., Gibson,M.S., and Schulnan,I.: Effects of
antenatal drug administration on platelet function of newborn infants.
J. Ped. 79:307, 1971.

Corby, D.G., and Schulman, I.: Effect of bilirubin on unwashed platelets
in experimental hyperbilirubinemia. J.Ped. (in press).

P-217
SECTION If — PRIVILEGZD COMMUNICATION Frf 5 Beet! a)
BIOGRAPHICAL SKETCH liinten

(Give the foliowing information for all professional personnel listed on page 3, beginning with the Princizal Investiciion
Use Continuation pages and fallow the same general format for each person]

 

 

 

 

NAME TITLE < BIKTRDATE [..'3, co.
Herbert C. Schwartz Professor of Pediatrics May 8, 1925
PLACE OF BIATH (City, State, Country) PRESENT NATIONALITY (if ron-U.S. citizen, SEX
; indicate kind of visa and expiration date)
New Haven, Connecticut U.S.A. mo
Mola _

 

EDUCATION (8coin with beccelaureate training and include postdoctoral)

 

INSTITUTION AND LOCATION YEAR
DEGREE CONFERRED

 

 

Alma College, Alma, Michigan
Illinois Institute of Technology, Chicago

 

 

 

Yale University, New Haven, Connecticut A.B.” 1948 Psychology-Chen.
- State University of New York, Brooklyn M.D. 1952
HONORS ~

 

John and Mary Markle Scholar in Academic Meeicine (1962); Visiting Prof. State Univ.
Netherlands (1967); SOCIETTES: Society for Pediatric Research (1961); American Scc..

Clinical Invesgigation (1962); American Pediatric Society (1967), etc.

 

MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT

Hemoglobin Structure and Synthesis Investigator

 

 

RESEARCH SUPPORT (Se instructions}
U.S.P.H.S. Grant POl AM 12467-10, Forration of Hemoglobin and Other Hemeproteins

«pe pee

June 1, 1968, to May 31, 1973. Current year $28,866. Total (Years 6-10) $145,235.

 

. RESEARCH AND/GR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevent to rea cf o-2t
OF mast representaive publication. Oe not exceed 3 goges for esch individual.)

1968 - 1971 Professor of Pediatrics, Stanford University

1969 - 1971 Chairman, Department cf Pediatrics, Stanford University

1963 ~ 1968 Associate Profesecr cof Pediatrics, Stanford Unversity

1960 - 1963. Assistant Professor of Pediatrics, Stanford University

1958 =.1950 Research Instructor in Medicine, University of Utah

1957 - 1958 Research Fellow in Biochewistry, University of Utah

1955 - 1957 Research Fellow in Medicine ( Hematology ), University of Utah

“.

Publications (Selected from a total of 19.)

Schwartz, H.C., Cartwright, G.E., Smith, E.L., and Wintrobe, M.M.: Studies on the
thesis of Heme from Iron and Proteporphyrin, Blood 14:456, 1959.

Hill, R.L., Swenson, R.T., and Schwartz, H.C.: Characterization of a Chenical Ar
in Heroglobin G. J. Biol. Chom, 235:3182, 1960.

Gribble, T.J., and Schwartz, H.C.: Effect of Protoporphyrin on Hemoglobin Synih.c:.
chem. Biophys. Acta. 103:333, 1965.

Dallmwan, F.R. and Schwertz, WC. Myoglobin and Cytochrome Response during Rests
Deficiency in the kac. J. Clin. Invest. 44:1631, 1265.

Walters, T.R., Welland, F.H., Gribble, T.J.,-and Schwartz, H.C.: Biosynthesis >:
Leukemic Leukocytes, Cancer 20:117, 1967.

Lincoln, D., Edmunds, D.d., Gritble, T.J.,and Schwartz, H.C.: *
blcod..da- press,.Jannary.,—12 13). ee cee ; on fern:

Pinnined Roveeto

 

 
e

~ Prof, J. Lecerterg

CURRICULUM VITAE

Eric M. Shooter

Born: April 18, 1924 Mansfield, Nottingham, England.

Married: Elaine Arnold (Born Dec. 22, 1924) Newhall, Burton-on-Trent.
Children: Annette (Born Nov. 18, 1956) Redhill, Surrey, England.

Permanent Address: Department of Genetics
Stanford University School of Medicine
Stanford, California 94305

1942-45 Natural Sciences Tripos (Part II in Chemistry)
University of Cambridge

1942 Exhibitioner of Gonville & Caius College, Cambridge
1943 Minor Scholar of same.
1945 B.A. (Cantab.)

1945-46 Research under Professor Sir ‘Eric Rideal in the Department of
1946-49 C-lloid Science, Cambridge and the Davy Faraday Laboratory of
the Royal Institution, London (Proteins of the ground nut).

1949 M.A. (Cantab.) .
1950 Ph.D. (Cantab.)

1949-50 Postdoctoral Fellowship with Dr. J. W. Williams, Department of
Chemistry, University of Wisconsin, Madison, and partly with
Dr. D. E. Green, Enzyme Institute, University of Wisconsin.
(Enzymes of the electron transport system).

1950-53 Senior Scientist in charge of Biochemistry, Brewing Industry
Research Foundation, Nutfield (Proteins and enzymes of barley
and other brewing materials).

1953-63 Lecturer in Biochemistry, Department of Biochemistry, University
‘College, London with Professor Ernest Baldwin. (Molecular
biology of normal and abnormal haemoglobins; protein-ion inter-
actions of ribonuclease). =

1961-62 U.S.P.H.S. International Fellow, Department of Biochemistry,
Stanford University School of Medicine, with Professor R. L.
Baldwin (Replication of DNA).

1963-68 Associate Professor of Genetics, Stanford University School of
Medicine (Molecular Neurobiology). Head of Neurobiology Group,
Lt. Joseph P. Kennedy, Jr. Laboratories for Molecular Medicine.

1964 D.Sc. University of London (awarded for distinguished work in
the field of Biochemistry).
1968 Professor of Genetics, Stanford University School of Medicine.

1968-present Professor of Genetics and Biochemistry, Stanford University
School of Medicine.

p-209

alee
69.

70.

71.

72.

73.

74,

75.

76.

77.

78,

79.

80.

Varon, S., Nomura, J. and E. M. Shooter, 1968. Reversible dissociation of
the mouse nerve growth factor protein into different subunits. Biochemistry
7, 1296-1303.

Shooter, E. M., Smith, A. P., and S. Varon, 1968. Heterogeneity of the nerve
growth factor protein and its subunits. Fed. Proc. 27, 464.

Herschkowitz, N., McKhann, G. M., Saxena, S. and E. M. Shooter, 1968.
Characterization of sulfatide-containing lipoproteins in rat brain. J.
Neurochem. 15, 1181-1183.

Smith, A. P., Varon, S. and E. M. Shooter, 1968. Multiple forms of the nerve
growth factor protein and its subunits. Biochemistry 7, 3259-3268.

Greene, L. A., Shooter, E. M. and S. Varon, 1968. Enzymatic activities of
mouse nerve growth factor and its subunits. P.N.A.S. 60, 1383-1388.

McKhann, G. M. and E. M. Shooter, 1969. Genetics of Seizure Susceptibility
in Basic Mechanisms of the Epilepsies, H. H. Jasper, A. A. Ward, Jr., and ,
A. Pope, Ed., Boston, Little, Brown and Company, Chapter 24.

Herschkowitz, N., McKhann, G. M., Saxena, S., Shooter, E. M. and R. Herndon
1969. Synthesis of sulfatide-containing lipoproteins in rat brain. J.
Neurochem. 16, 1049-1057.

Goodall, P. T. and E. M. Shooter, 1969. Changes in Heme Environment due to
subunit interaction in hemoglobin. J. Mol. Biol. 39, 675-678.

-

Smith, A. P., Varon, S. and E. M. Shooter, 1969. Equilibria of the Nerve
Growth Factor proteins and their subunits. Fed. Proc. 28, 897.

Greene, L. A., Shooter, E. M. and Silvio Varon, 1969. Subunit interaction
and enzymatic activity of mouse 7S Nerve Growth Factor. Biochemistry 8,
3735-3741.

Shooter, E. M., Smith, A. P., Greene, L. A. and S. Varon, 1969. Aspects

of the dissociation equilibria between 7S NGF and its subunits. Abstracts

of Second International Meeting of the International Society for Neurochemistry,
p. 366.

Waehneldt, T. V., Grossfeld, R. M. and E. M. Shooter, 1969. The solubili-
zation and electrophoretic analysis of membrane proteins from mouse brain.
Abstracts of Second International Meeting of the International Society for
Neurochemistry, p. 411.

P-220
&l.

82.

83.

84.

$5.

a6,

87,

88,

89,

90,

91,

Smith, A. P., Greene, L. A., Fisk, H. R,., Varon, S. and E, M. Shooter,
1969, Subunit equilibria of the 7S Nerve Growth Factor protein, Bio-
chemistry 8, 4918-4926.

Shooter, E. M. and S. Varon, 1970, Macromolecular aspects ef the Nerve
Growth Factor proteins in Pratein Metabolism of the Nervous System, A.
Lajtha, Ed., New York, N.Y¥., Plenum Presa, 419-438,"

Varon, $, and E, M, Shoater, 1970, The Nerve Growth Factar proteina of
the mouse submaxillary gland in Biechemistry of Brain and Behavior, R,
E, Bowman and S. FP, Datta, Edu, New York, Nw¥e, Plenum Presa, 41~64,

Shooter, E, M,, 1970, Some aspects of gene expression in the nervous
system in The Neuresciences; Second Study Program, F, 0. Schmitt, Ed,,
New York, N.¥., The Rockefeller University Preas, 912-827.

f .

Shooter, E. M, and §. Varon, 1971, Biological activities of the subunits
of the 7S Nerve Growth Factor pretein in Cellular Aspects of Neural
Growth and Differentiation, D, C, Pease, Ed,, VELA Forum in the Medical
Sclences, No, 14, 269-272,

Shooter, E, M. and Eliaaheth R, Einstein, 1971, Proteins ef the Nervous
System in Annual Review of Biochemiatry: Vol, 40, Be B, Snell, Ed.,

Annual Reviews, Inc., Palo Alta, Calif. 635-652,

Perez-Polo, J. R,, Bamburg, J, R, and E. M, Shooter, 1971, 75 Nerve
Growth Factor; a subunit containing protein, Fed. Prec. 30, 1194.

Greene, Lloyd A., Varon, &, Pilteh, A, and BE. M, @hoater, 1971, Sub-
atructure of the @ subunit ef the mouse 78 Nerve Growth Factor, Nevro-
biology de 37-48 *

Morris, 8. J., Louis, €, F, and BE, M, Sheeter, 1971, Separation of
myelin protein on two different polyacrylamide gel systems. Neuro-
biology 1, 64-67,

Perez-Polo, J. R, and E. M, Sheoter, 1971. Comparison ef the properties
of native and modified @ subunits of 78 NGF, Abstracts af the Third
International Meeting of the International Society for Nevrechemistry,
Budapest, Hungary, p, 212,

Shooter, E. M., Bamburg, J. R., Perea-Pola, J. Re, Piltch, A. and DB.
Straus, 1971, Structural studies an the 78 Nerve Growth Factor protein,
Abstracts of Tiird International Meeting af the International Society
for Neurochemistry, Budapest, Hungary, Pp. 428,

O-arl
SECTION I — PPIVILEGED COMMUNICATION . r
. BIOGRAPHICAL SKETCR

(Give the following information for alt protessionz! personnel listed on pz ze 3, beginning with the Principal Investigztor.
Use continuation paces and foilove the same general format for cach person.)

 

 

 

NAME TITLE BIRTHDATE {f!0,, Day, Vo)
Philip Sun e ‘As
ilip shin Associate Professor June 16, 1530
PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (/f non-US. citizen, SEX
. ; jadicate kind of visa and expiration date}
Denver, Colorado American 5 tat Jr
gby Mate emule

 

 

EDUCATION (Seoin with bsecelaureste training and include postdoctoral)

 

 

 

 

 

 

 

INSTITUTION AND LOCATIO! YEAR SCIENTIFIC
venp bose DEGREE CONFERRED FIELD
University of Colorado, Boulder, Colo. B.A. , 1952 Pre-Medicine
University of Colorado, Denver, Colo. ; M.D. °1955 Medicine
" HONORS
Alpha Omega Alpha Council Western Society for Pediatrics
Ross Award for Pediatric Research 1970 Research, 1972
MAJOR RESEARCH IITEREST ROLE IN PROPOSED PROJECT
Developmental Gastroenterology and
Nutriticn Investigator

 

 

RESEARCH SUPPORT (Sez instructions)

RR 81 - Clinical Research Center for Premature Infants, 10/159 - 9/30/74.
Amt. Current Year: $385,882. Total Amount: — $2,380,594 (Norman Kretchser -
Principal Investigator)

 

; RESEARCH AND/OR PROFESSIGNAL EXPERIENCE (Starting with present position, list training and experience relevant 19 area af projest: Lis:
Or most representative publications, Do not exceed 3 pages tor cach indiwidual.)

 

Associate Professor of Pediatrics 1968~-present Stanford Univ. School of Medicine
Director, Center for Premature Infants 1968- present Stanford Univ. School of Macicirs
Instructor through Assist. Professor 1963- 1968 Stanford Univ. School of Medicirs
Fellow in Pediatrics : “~~"1961-1963 Stanford Univ. School of Medicines
Resident in Pediatrics 1959-1961 Stanford Univ. School of Medicine

Publications (Selected)

Sunshine, P. and Kretchmer, N.: Studies of small intestine during development. II.

Infantile diarrhea associated with intolerance to disaccharides. Pediatrics 2:1:
38, 1964.

Sunshine, P. and Kretchmer, N.: Absence of intestinal disaccharidases in two specics
of sea lions. Science 144:850, 1964.

Herbst, J.J., Hurwitz, R., Sunshine, P. and Kretchmer, N.: Effect of colchicina on
intestinal disaccharidases: Corr with biochemical aspects of celluler
renewal, J. Clin. Invest. 49:530, 1970

Sunshine, P., Herbst, J.J., Koldovs ky, O. and Kretchner, N.: Adaptation of theo
gastrointesiinal tract to extrautcerine life. Amn. N.¥. Acad. Sci. 176:16-2°,
1971. . ‘

Sunshine, P., et al.: Hyperammonemia due to a defect in hepatic ornithine trapscart ©
Pediatrics 50:100, 1972.
RNS 35S Te Pussy

 
 

 

 

 

 

 

 

. BIOGRATHIT AL SKETCUES Pret. 3. Lete*pary
“8 (Give ths loliowiod infarction tor all professionst Personne | fisted on page 3, begianing with the PrincincDdnarsticatcss Genet rz
Use continuation pages and follow the «xme general fermet for each persemn.) . Urs
NAME TITLE BIRTHDATE (Mo., Day, 0.)
Tsuboi, Kenneth K. Sentor Scientist February 7, 1622
PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (if non-U.S, citizen, SEX
. indicate kind of visa and expiration date)
Kayama, Japan U.S.A. BO) Maile (—) Female
EDUCATION (Bedin with baccalaureate trainina and inelute posidostoral)
. ' 7 YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERRED FIELD
St. Thomas College, St. Paul, Minnesota B.S. 1944 Chen.
University of Minnesota, Minn., Minn. M.S. 1946 Biochen.
University of Minnesota, Minn., Minn. - | Ph.D. 1948 Biochen.

 

 

 

 

HONORS

Established Investigator, American Heart Association, 1960 - 1964.

 

MAJOR RESEARCH INTEREST . ROLE IN PROPOSED PROJECT
Biochenistry, Enzymology, Nucleotides,
Muscle Proteins Investigator

 

 

RESEARCH SUPPORT (Soo instructions)
_ Contract Avard: Division of Biologic Standards, N.I.H., Biochemical Parameters of

Primate Cell Cultures, June 1, 1972 to May 31, 1974. Current year $23,5°8, Total

$47,196. . -.

AM 0397€ Metabolism of Numan Erythrocyte, June 1, 1967 -- May 31, 1972.
Current $12,500. Total $102,880.

 

RESEARCH AND/OR PROFESSIONAL EXFORIENCE (Startins with present position, fist training and experience relevent ts atea of project.

Listalloer most repescatetive publicaticns. (Go not exceed 4G peges for each indivicuah)

1966 to present - Senior Scientist, biochemistry in Pediatrics

1960 - 1966 ~- Associate Professor, Eiochemistry in Pediatrics, Stanford Medical Schoo}
1957 - 1960 ~ Assistant Professor, Biochemistry in Pediatrics, Cornell Medica i

1951 - 1957 ~ Kesearch Associate, biochemistry, Columbia University Medical $
1948 - 1951 ~ Research Associate, Oncology, University of Kansas Medical Sch

Publications (Five relevant publications are listed from a total of 48).
Tsuboi, K.K., Greenberg, R.E., and Kretchmer, N.: Carbohydrate Metabolism, in 34.
Basis of Pediatric Practice, R.E. Cooke, ed., McGraw-Hill (1968).

{cy
fia
ia
ae)
3.
QO
ey

 

¢

Tsuboi, K.K., Fukunaga, K., and Petricciani, J.C.: Purification and Specific Kinecic
Properties of Erythrocyte Uridine Diphosphate Glucose Pyrophosphorylase. J.ziol. Chan.
244, 1008 (1969).

Tsuboi, K.K., Fukunaga, K.: Relationship of solute permeability to erythrocyte g]vcolysis.
Biochem. Biophys. Acta, 196, 215 (1970).

Uchino, J. and Tsuboi, K.K.: Actin Accumulation in Developing Rat Muscle. Amer. J.
Physiology, 219, 154 (1970).

Tsuboi, K.K., Fukunasa, K., and Chérvenka, ¢.H.: Phosphoglucose Isomerase from Huns
Erythrocyte Preparation and Properties. J. Biol. Chem., 246, 7586 (1971).

 

AES.368 . —

Rev, 2-69 P- 223