Research Proposal Submitted to the National Science Foundation

Proposed Amount $294,476 Proposed Effective Date 6/1/78 _ Proposed Duration 24
(months )

 

Title MOLGEN: A Computer Science Application to Molecular Genetics

 

Principal Investigator Edward A. Feigenbaum supmitting

Institution Stanford University
Soc. Sec. No.

 

 

 

 

 

 

 

 

Department Computer Science
Institution Branch/C
(if different from submitting institution) en/vanpus:
Address Stanford, California
Addres ’
ess 94305
Branch/Campus
Co-Principal Investigator___Joshua Lederberg Soc.. Sec. » iim
Co-Principal Investigator Soc. Sec. No.

 

 

‘

If renewal request previous NSF grant No. MCS 76-11649

Make grant to Stanford University
(name of institution or organization to which grant should be made)

Endorsements:
Principal Investigator(s) Dept. Head Institutional Admin. Offic:

Name Edward A. Feigenbaum
/ . .
Signature Edit A, Fljende— Edin 4h Fecaebe
7 :
¢

Title Professor and Chairman

 

Telephone Number
415-497-4079

Date October 27, 1977
October 27, 1977

Table of Contents

Section Page
Subsection

1. Introduction - ee leh elle ll 1
1. 1 Motivations e * e * e e e . a a e e a 4

1.2 Progress To Date . . «1 « © © «© © «© «© «© e 4
1.3 Plans for the Remainder of this Grant Period . . . 12
1.4 An Example of the Genetic Utility of Automated
Experiment Design . . « «© » »© © « «# «© «© JY
2. Research Plans a

2.1 Building and Maintaining the Genetics Knowledge
Base ee le le ee

2.2 Recognizing and Abstracting and Saving
Successful Plans. . .« «© « «© »© «© «© «© « « 22

2.3 Understanding Experimental Discrepancies by
Hypothesis Formation . .« « « «© »© «» «»© «© « 25

2.4 Reasoning by Analogy . . « «© 2 © «© «© «© « « 33
2.5 Performance Evaluation and Improvement of AI
Knowledge-Based Systems > 8 8 @© e© ew eh hehe (C8
3. Significance oe ee ele le le le le ll
3.1 Significance to Computer Science . . . + «+ + « 44
3.2 Significance to the Conduct of Experimental

Science and to Science Policy . . . +6 « « « 46

4. Budget . , . . ° ° e * . . e. @ . e . « 49
5.

Resources :
Appendix I

_ GLOSSARY .
Appendix II

EDNA -- The Editor for DNA

‘Appendix III

A Genetic Planning Example

References .

ii

October

27, 1977

50

52

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