Page ! of 2

Research Proposal Submitted to the National Science Foundation

*

Proposed Amount_113,544 Proposed Effective Date 6/1/76 _ Proposed Duration_24
(months )

Title MOLGEN: A Computer Science Application to Molecular Genetics

 

Principal Investigator Submitting
Institution Stanford University

Soc. Sec. No.

 

Department _ Computer Science

 

 

 

 

Institution . .
M

(if different from submitting institution) Branch/Campus__Main

Address Address Stanford, California 94305

Branch/Campus

 

Co-Principal Investigator [Edward A. Feigenbaum Soc. Sec. No.

Co-Principal Investigator Joshua Lederberg Soc. Sec. —

4

If renewal request previous NSF grant No.

 

Stanford University

Make grant to
(name of institution or organization to which grant should be nade )

 

 

 

Endorsements:
Principal Investigator(s) Dept. Head Institutional Admin. Official -
Name Edward A. Feigenbaum Robert Floyd D'Ann Downey
creates tn h. Fg bee Seb t SGA A
Title Professor of Chairman, department Asst. Sponsored
Computer Science of Computer Science Projects Officer

 

Telephone Number

(415) 497-4878 (415) 497-2274 (415) 497-2883

Date
Page 2 of 2

Research Proposal Submitted to the National Science Foundation

Provosed Amount_ 113,544 Proposed Effective Date 6/1/76 Proposed Duration 24
(months)

Title MOLGEN: A Computer Science Application to Molecular Genetics

 

 

 

 

 

 

 

 

 

 

 

 

 

Principal Investigator Submitting
ti i Stanford Universit

Soc. Sec. No. Tnstitution tty

Department Computer Science
Institution .

Main
(af different from submitting institution) Branch/Campus

Address Stanford, California 94305
Address
Branch/Campus
Co-Principal Investigator Edward A. Feigenbaum Soc. Sec. No.
Co-Principal Investigator Joshua Lederberg Soe. Sec. No.

 

 

\

If renewal request previous NSF grant No.

 

Make grant to Stanford University
(neme of institution or organization to which grant should be made)

Endorsements:

 

 

 

 

 

rincipal Investigator(s) Dept. Head Institutional Admin. Offici -
Name Joshua Lederberg oshua Lederberg D'Ann Downey
signature at .
Title préicheor & Chairman profesloy & Chairman Asst. Sponsored
Department of Genetics Department of Genetics Projects Officer
Telephone Number
(415) 497-5801 (415) 497-5801 (415) 497-2883

 

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O
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1 PROLOGUE

The scientific text of this proposal is identical with that of
the companion from the University of New ‘“exico. The budget is
separate and it will be administered by Stanford University as
indicated in the budget page. We realize that this is an unusual
procedure but we feel it is justified as a means of bringing
geographically separate scientists together to work on common problems.
The personnel involved in the proposals began working together on the
organization of the project in June, 1975 when Prof. Martin visited
Stanford for the summer. We are proposing that Martin spend the major
part of the first year at Stanford, working closely with the Stanford
group on all phases of the foundation of the systen. This is strongly
supported by Prof. D. Morrison, chairman of the Division of Computing
and Information Science at UNM. The second year Martin will return to
UNM to continue working on special subparts of the system with the aid
of a UNM graduate research assistant. Constant connunication can be
maintained through the excellent SUMEX-AIM time sharing installation as
outlined in the Resource Section. of this proposal. At regular
intervals all participants in the project will meet at Stanford to

review progress and suggest new directions.
Section

Table of Contents

Subsection

Introduction ° . . ° . ° e . ° .

Background and Related Work . - © © © © © 8

2.1 Relationship to Other Research in Artificial
Intelligence. - . . . . . - «

2.2 Related Work in Computers Applied to Genetic
Biochenistry . . . . . . . . . .

2.3 Supporting Research at the Stanford Heuristi
Programming Project . . . . ° . . °

Detailed Plans for Work During the Proposal Period

3.1 Introduction . - . . 8 ~ 6 e
3.2 An Experimental Planning Program . ° . .
3.3 An Enzyme Simulation Program . ° - 8
3.4 Knowledge Base ., . . . . . . . . .
3.5 A DNA structure entry and editing systen .
Resources ° . e . e ° . . ° °
Bibliography . . . - . . . . .
Personnel . . . . . . ° . . .
Budget . . . ° . . . . . .

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