Total Resource Budget
1. Budget, Biographies, and Environment

1.1. Total Resource Budget

This section details the Total Resource Budget starting with the first renewal year
(resource year 14) beginning August 1, 1986.

Privileged Communication 1 E. H. Shortliffe
TOTAL RESOURCE BUDGET :
PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR: FE. 8. Shortliffe

FROM THROUGH
DETAILED BUDGET FOR FIRST 12 MONTH BUDGET PERIOD 8/1/86 7/31/87
DIRECT COSTS ONLY

DOLLAR AMOUNT REQUESTED (Omir cenr
PERSONNEL (Agaticant organization oniy) i TIME/EFFORT |

 

 

FRINGE

j ALARY TOTALS
NAME POSITION TITLE | % | Hours oer | s BENEFITS

Week

 

 

 

 

Princigal Investiqator |

see attac

  

SUBTOTALS ee | 650

 

CONSULTANT COSTS

 

EQUIPMENT ffremizes

 

 

 

 

Resource host and network equipment $14,000
Experimental Lisp Machines $75,000
89,000
SUPPLIES (ftemize by category)
Office supplies 4,350
Computer supplies 4,250
Engineering supplies 7,500
. 16,100
TRAVEL DOMESTIC 9,500 9,500
FOREIGN
PATIENT + INPATIENT
GARE COSTS OUTPATIENT

 

 

 

ALTERATIONS AND RENOVATIONS (/temize by category)

 

CONSORTIUM/CONTRACTUAL COSTS

 

OTHER EXPENSES (itemize by category) File server maintenance: $19,200; Terminal
maintenance: $1,350; Lisp Machine maintenance: $30,000; Misc. software: $1,800
Aux. computing services: $3,000; Documentation: $1,000; Books/publications:
$2,650; Office telephones: $13,100; Dataphone lines: 34,000; Repro/services:
22,700; Prorated 2060 Opns Costs (80%): $347,582 426,382

t

 

TOTAL DIRECT COSTS (Also enter on page f, item 7)

 

1.370.257

 

PHS 398 (Rev, 5/82) PAGE 2
First Year Personnel Detail

RESOURCE MANAGEMENT
E. Shortliffe
E. Feigenbaum
- Rindfleisch
. Fagan

. McCabe
- Timothy
Open

CORE SYSTEM DEVELOPMENT
. Sweer

. Gilmurray

. Croft

. Acuff

C. Schmidt

N. Vetzades

I. Torres

CORE BASIC AI RESEARCH
Buchanan
Hayes~Roth

Brown

Nii

T
L
W. Yeager
P
M

aun S

.
x
=
“4

o

GruEeEVIOS
Qax=
ooo
73 &
<u @®
oa
<

a
3
c
2
oe
@

CORE ONCOCIN RESEARCH
C. Jacobs
R. Lenon
C. Lane
S. Tu
O. Combs
O. Vian
J. Rohn
A. Grant
T. Barsalou
L. Perreault

SYSTEM OPERATIONS SUPPORT
R. Tucker
P, Ryalts

Privileged Communication

%
Principal Invest. 15
Co-Principal Inv. 10
Resource Director 70
AIM Liaison/ONC Proj. 25
Mgr.
Asst. Resource Dir. 390
Administrator 75
Secretary 100
Receptionist 75
Systems Poqmr. 10
Systems Pqmr. 70
Systems Pgmr. 100
Systems Pgmr. 60
Systems Pgmr. 60
Electronics Engr. 40
Engr. Atd 40
Professor of Comp. Sci. 10
Sr. Res. Assoc. 15
Sr. Res. Assoc. 10
Res. Assoc. 10
Programmer 40
Res. Asst. 62
Res. Asst. 62
Res. Asst. 62
ONCOCIN Investigator 5
Clinical Spec. 25
Systems Pgmr. 60
Sci. Programmer 50
Sci. Programmer 50
Administrator 25
Data Mgr. 100
Secretary 50
Res. Asst. 62
Res. Asst. 62
Opns. Mgr. 20
System Mgr. 20

SUBTOTAL DIRECT SALARIES
STAFF BENEFITS
TOTAL OF PERSONNEL

SALARY BEN

Total Resource Budget

TOTAL

660335
168940
829275

E. H. Shortliffe
TOTAL RESOURCE BUDGET

PRINCIPAL INVESTIGATQR/PROGRAM DIRECTOR: E. H. Shortliffe

 

BUDGET FOR ENTIRE PROPOSED PROJECT PERIOD
DIRECT COSTS ONLY

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

BUDGET CATEGORY wy cRio. ADDITIONAL YEARS SUPPORT REQUESTED
TOTALS 7
{from page 4) 2nd 3rd 4th Sth
PERSONNEL (Salary and
fringe benefits.)
(Applicant organization onty) 829 ,275 891,340 989,154 1,063,465 1,143,264
CONSULTANT COSTS
EQUIPMENT 89,000 95,230 101,897 109 ,029 116,661
SUPPLIES 16,100 17,228 18,433 19,723 21,104
DOMESTIC 9,500 10,165 10,877 11,638 12,453
TRAVEL
FOREIGN
PATIENT INPATIENT
CARE
COSTS {OUTPATIENT
ALTERATIONS AND
RENOVATIONS
CONSORTIUM/
CONTRACTUAL COSTS
OTHER EXPENSES 78,800 84,317 90,219 96,533 103 ,290
Prorated 2060 Opns. 347,582 2296.16 200,050 107,304 2
TOTAL DIRECT costs | 1,370,257 1,377,896 1,410,630 1,407 ,692 1,396,772
TOTAL FOR ENTIRE PROPOSED PROJECT PERIOD (Also enter on Page 1, (te 8) meen | S 6, 963 3247

 

 

JUSTIFICATION (Use continuation pages if necessary): Describe the specific functions of the personnel and consultants. If a recu fring annual increas
in personne! costs is anticipated, give the percentage. For a// years, justify any costs for which the need may not be obvious, such as equipment, foreig
travet, alterations and renovatians, and consortium/contractuai costs. For any additional years of support requested, justify any significant increases :
any category over the first 12 month budget period. In addition, for COMPETING CONTINUATION applications, justify any significant increases ove

the current jevel of support.

 

PHS 398 (Rev. 5/82)

PAGE 4
Total Resource Budget

1.2. 2060 Operations Budget

The budget in this section is for the projected operations costs of the 2060 mainframe
system that has been the main resource for national and local users. We will be
phasing this link with the past out over the 5-year term of this grant in favor of the
new distributed workstation environment we plan to develop. As the first step in the
phase-out, we have included 80% of the first-year 2060 operating costs in the first-year
Total Resource Budget above. In future years, we include proportionately less of these
costs, reducing the pro rata share by 20% per year.

Privileged Communication 5 E. H. Shortliffe
2060 OPERATING BUDGET :
PRINCIPAL INVESTIGATOR/PROGRAM DirEcToR: ©: H+ Shortliffe

DETAILED BUDGET FOR FIRST 12 MONTH BUDGET PERIOD

8/1/86 7/31/87
DIRECT COSTS ONLY DOLLAR AMOUNT REQUESTED (Om cents

 

 

FROM THROUGH

 

 

 

   

PERSONNEL (Apoicane szauon only} TIME/EFFORT

Hours oer SALARY
Week

FRINGE

NAME POSITION TITLE % BENEFITS TOTALS

Principal |

SUBTOTA LS rene |

CONSULTANT COSTS

 

 

 

 

 

 

 

 

 

 

 

 

 

 

EQUIPMENT (/temuze/
2060 Accessories and Equipment 6,000
6,000
SUPPLIES {ftemize by category)
Office supplies 920
Computer supplies 8,000
Engineering supplies 1,500
10,420
DOMESTIC 1.500 1 500
aneNEL FOREIGN
INPATIENT
PATIENT CARE COSTS OUTPATIENT
ALTERATIONS AND RENOVATIONS {irermmze by category)
CONSORTIUM/CONTRACTUAL COSTS
OTHER EXPENSES (/cemuee oy category) 2060 maintenance: $92,300; DEC software maintenance:|
$3,950; Software licenses: $6,800; Documentation: $1,200; Books/publications:
3625; Office telephones: $2,935; Dataphone lines: $14,000; Repro/services:
$825; TYMNET network services: $60,000 182.635
TOTAL DIRECT COSTS (Also enter on page I, tem 7) $434,478
{ +

 

PHS 398 (Rev. 5/82) PAGE 6
First Year Personnel Detail for 2060 Operations

MANAGEMENT
T. Rindfleisch
W. Yeager
P. McCabe

SYSTEM STAFF
Sweer
F. Gilmurray

ELECTRONICS STAFF
N. Veizades
I. Torres

OPERATIONS SUPPORT
R. Tucker
P. Ryalls
M. Blattel
N. Dothert
A. Jong

Privileged Communication

Resource Director

Asst. Resource Dir.

Administrator

Systems Pgmr.
Systems Pgmr.

Electronics Engr.
Engr. Aid

Opns. Mgr.
System Mgr.
Student Oper.
Student Oper.
Student Oper.

10
25

90
30

%

SUBTOTAL DIRECT SALARIES

STAFF BENEFITS
TOTAL OF PERSONNEL

2060 Operations Budget

SALARY

186268
47655
233923

BEN TOTAL

E. H. Shortliffe
2060 OPERATING BUDGET

PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR:

——

E. H. Shortliffe

 

 

BUDGET FOR ENTIRE PROPOSED PROJECT PERIOD

DIRECT COSTS ONLY

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

BUDGET CATEGORY 1st BUDGET ADDITIONAL YEARS SUPPORT REQUESTED
TOTALS PERIOD
{from page 4} 2nd 3rd 4th 5th
PERSONNEL (Salary and
fringe benefits.)
(Applicant organization only] 233,923 251,433 270,510 290,830 312,656
CONSULTANT COSTS
EQUIPMENT 6,000 6,420 6,869 7,350 7,865
SUPPLIES 10,420 11,149 11,929 12,765 13,658
DOMESTIC 1,500 1,605 1,717 1,838 1,966
TRAVEL
FOREIGN
PATIENT | INPATIENT

CARE

COSTS | OUTPATIENT
ALTERATIONS AND
RENOVATIONS
CONSORTIUM/
CONTRACTUAL COSTS
OTHER EXPENSES 182 ,635 195,420 209,099 223,737 239,396
TOTAL DIRECT COSTS 434,478 466,027 500,124 536,520 575,541
TOTAL FOR ENTIRE PROPOSED PROJECT PERIOD (A/so enter on page 1, item 8) ——-——_» | $ 2,512,690

 

 

JUSTIFICATION (Use continuation pages if necessary): Describe the specific functions of the personnel and consultants. if a recurring annual increa:
in personnel costs is anticipated, give the Percentage. For a/f years, justify any costs for.which the need may not be obvious, such as equipment, foreic
travel, alterations and renovations, and consortium/contractual costs. For any additional years of support requested, justify any significant increases

any category over the first 12 month budget period. In addition, for COMPETING CONTINUATION applications, justify any significant increases ov:

the current tevei of support.

Of these costs, the following are included in the resource budget:

Year 1: $347,582 (80%)
Year 2: $279,616 (60%)
Year 3: $200,050 (40%)
Year 4: $107,304 (20%)
Year 5: -0- ( 0%)

 

PHS 398 (Rev. 5/82) PAGE 8
2060 Operations Budget

1.3. Budget Explanation and Justification

1.3.1. Total Resource Budget

This section explains the details of our resource budget plan over the proposed five
year grant term, including both the SUMEX renewal and the merged ONCOCIN
Dissemination Studies core research (see page 53). Details of the 2060 operations costs
are explained in the next section.

In overview, this budget covers a portion of the resource core research and management
costs, basic workstation and network environment operations costs and a prorated share
of the mainframe computing facility operations costs for the local and national
communities. Reviewers will note that only portions of most resource staff members
are charged to this budget, the remaining salary support coming from other funding for
individual core research and collaborative projects (see page 105). Also, the proposed
funding for experimental Lisp machine hardware is a small fraction of the total
workstation hardware investment already in place from support received from NIH,
DARPA, ONR, and industrial gifts. As a benchmark of the relative magnitude (and
hence leverage) of the proposed funding for this resource grant, as compared to other
sources of support for this work, consider a snapshot of the year 1 budget. The
proposed $1.37M direct cost funding translates to approximately $2.25M in total costs
(including indirect costs) as compared to well over $6M in annual total cost funding for
KSL work at Stanford. This does not include estimates of the funding base for non-
Stanford collaborative users of the resource. It should be emphasized though that this
DRR support of the SUMEX-AIM computing resource has been and remains an
essential enabling complement to the other sources of support and makes possible the
overall scope of our work.

Reviewers will also note that our 5-year budget is essentially flat, despite the inclusion
of 7% annual inflation factors. This is because we have linearly phased-out requested
DRR support for what has been the mainstay SUMEX-AIM resource, the DEC 2060.
In the coming era of workstations, we feel it is important to withdraw support from
that part of the resource, but to do so in a responsible fashion that allows time for the
national community of projects to find alternative sources of computing support and
for core system developments to offer alternatives for our own work and that of the
national community. We budget no DRR support for the DEC 2020 demonstration
machine or the shared VAX 11/780 time-sharing machine.

Indirect costs are not shown in the budget and will be awarded separately on the basis
of Modified Total Direct Costs. The indirect cost rate of 69%, is based on an agreement
with the Office of Naval Research (ONR) dated September 14, 1984.

Personnel

The proposed personnel budget is based on current staffing necessary for the proposed
work. The estimates are derived from actual salaries for our project staff, including
resource management, core research and development, and operations support for
collaborative projects. The salary estimates are increased at 7% per year to cover
estimated inflation. Staff benefits are computed using the following rates projected by
the university for all personnel: 25.4% (9/85-8/86), 25.6% (9/86-8/87), 26.2%
(9/87-8/88), 26.9% (9/88-8/89), 27.5% (9/89-8/90) and 28.1% (9/90-8/91).

Resource Management and Overall Technical Direction

Professor Shortliffe (15%) is the resource Principal Investigator, Professor Feigenbaum

Privileged Communication 9 E. H. Shortliffe
Budget Explanation and Justification

(10%) is co-Principal Investigator, and Mr. Rindfleisch (70%) is the Resource Director.
All three are responsible for overall resource management and contribute substantially
to core research and development efforts as well. Mr. Yeager (90%) is Assistant
Resource Director and has responsibility for network and workstation system
development. Dr. Fagan (25%!) is responsible for liaison with the national AIM
community and the AIM management committees and is Manager of the ONCOCIN
core research project.

Ms. McCabe (75%) and Ms. Timothy (100%) provide central resource administrative and
clerical support for SUMEX and community activities. We plan to hire a receptionist
shared between the SUMEX and ONCOCIN/Medical Computer Science groups during
the summer of 1985. This person is shown as “Open” and is budgeted at (75%).

Core System Development

The core system development staff, while sharing a substantial joint responsibility for
system development, maintenance, user assistance, and operational support, have specific
areas of responsibility as follows. Under the direction of Mr. Yeager, already
mentioned above, the development of network virtual communications, shared task
execution among cooperating workstations, and virtual graphics capabilities will be
shared appropriately among staff experts for various relevant environments. In
addition, Andy Sweer (10%) and Frank Gilmurray (70%) are responsible for workstation
user support and subsystem development such as the merging of text and graphics from
various sources and uniform access to printing facilities. William Croft (100%) is
responsible for our multiprotocol UNIX file server systems, the development of
IP/UDP high-performance file access capabilities, necessary modifications to local area
network gateway and interface systems, and network system performance evaluation.
Richard Acuff (60%) and Christopher Schmidt (60%) are responsible for Texas
Instruments Explorer, Symbolics 3600, and Xerox D-machine support and development.
This includes, for example, responsibility of systems support and integration within our
Ethernet environment, user support, and vendor liaison. They also are responsible for
development of specific system-dependent packages such as electronic mail, text and
graphics generation, file management, etc.

Finally, we budget Mr. Nicholas Veizades (40%) as the project electronics engineer and
Mr. Israel Torres (40%) his assistant for hardware and maintenance. Mr. Veizades and
Mr. Torres are responsible for designing needed special purpose hardware (eg.,
communications equipment, intermachine network hardware, and Ethernet interfaces)
and for integrating new hardware into the facility, maintaining facility equipment, and
correcting communication problems.

Core Basic AI Research

We continue to budget partial support for specific members of the Knowledge Systems
Laboratory for core research work to explore basic AI issues relating to biomedical
applications and to develop and generalize AI software tools important to the entire
SUMEX-AIM community. Prof. Buchanan (10%) will provide managerial and technical
direction for staff and students working on proposed core research efforts. Dr. Hayes-
Roth (15%) will work on the knowledge-based blackboard control research for the BB1
system which is the tool being used by the PROTEAN project. Dr. Brown (10%) is
working on issues of blackboard system design for hierarchical asynchronous

Iparing renewal years 1 and 2, Dr. Fagan is budgeted at only 25%, because part of his salary is
supplemented by a New Investigator Award. During years 3-5, when the term of that award ends, he is
budgeted at 55%.

E. H. Shortliffe 10 Privileged Communication
Budget Explanation and Justification

concurrency and Ms. Nii (10%) is working of a retrospective of the AGE blackboard
system and the ramifications of this control structure for symbolic computing
architectures. Mr. Hewett (40%) is a research programmer who will work on knowledge
acquisition research. Messrs. Karp, Garvey, and Brugge and graduate Research Assistants
who will work on qualitative simulation, learning, and blackboard architecture research
respectively.

Core ONCOCIN Dissemination Research

Dr. Charlotte Jacobs (5%) is Co-Principal Investigator on the ONCOCIN Project and is
director of the Oncology Clinic at Stanford. She will continue to oversee the clinical
implementation of the ONCOCIN workstations in the day-care center. Dr. Rick Lenon
(25%), is a clinical oncologist in practice in the community who is dedicating some of
his time to assisting with the ongoing development of the ONCOCIN knowledge base.
As an expert in oncology and in clinical trials, he takes primary tesponsibility for the
quality and currency of the knowledge base. Christopher Lane (60%) is a systems
programmer responsible for integrating and adapting the network virtual
communications, shared task execution, and virtual graphics work with ONCOCIN core
developments and dissemination experiments. He will also do the development of other
ONCOCIN core system tools such as the object-oriented system. Mr. Samson Tu (50%),
is a scientific programmer responsible for the EONYX research work under Dr. Fagan's
direction. Mr. David Combs (50%), is a scientific programmer responsible for the
EOPAL and METAOPAL research described in the body of the proposal. Ms. Janice
Rohn (100%) is the data manager and oversees the clinic operation on a day-to-day
basis. She also assists in data collection analysis for evaluation of ONCOCIN. Ms.
Alison Grant (50%) is secretary for the ONCOCIN Project and co-ordinates ail day-to-
day office activities.

System Operations Support

Mr. Tucker (20%) is the Operations Manager and is responsible as our network liaison
and for technical aspects of software export and overseeing system operations and
backup. Ms. Ryalls (20%) acts as the system administrator, taking care of file space
and directory allocations, providing system and user support for the resource,
accounting, and assisting new projects get started on the resource.

Consultant

We do not plan any consulting support this renewal term.

Equipment Purchase

$14,000 per year is allocated for minor equipment purchases for the resource including
communications equipment, Ethernet interfaces, local network gateway and TIP
equipment, and workstation memory. We also allocate $75,000 per year for
experimental Lisp workstations to support our core system development and
dissemination studies. During the first year we expect to buy 4 Xerox 6045-based
machines which will market for $18,000-19,000 each. In future years we will select
from available machines such as the Texas Instruments VLSI-based machine that is
being developed under DARPA funding, a machine that Hewlett Packard is developing,
and announcements expected from Japanese manufacturers. These machines will allow
us to remain current with the rapidly developing Lisp machine market for our own
system development and also to maximize the service we can provide to the national
community in developing applicable software for systems that those groups may
purchase. This budget is increased by 7% per year to accommodate inflation.

Privileged Communication 1l E. H. Shortliffe
Budget Explanation and Justification

Supplies

Office supplies are budgeted at $4,350 based on our past experience. Computer supplies
are budgeted at $4,250 projecting recent workstation operating experience and including
paper, disks, tapes, labels, laser printer supplies and other supplies needed for the
computer facility. Engineering supplies are budgeted at $7,500 to cover needed parts
and spares for maintaining in-house equipment and developing, interfacing, and
integrating new equipment. We plan for continued development of Ethernet services
needed to support existing and new Lisp machines, printers, and file servers at SUMEX.
We have budgeted a 7% per year increase for all supplies

Travel

The travel budget covers domestic travel for staff to professional meetings, management
committee meetings, and AIM workshop meetings. We budget $9,500 total for 4 east
coast trips ($1400 each), 2 midwest trips ($1,000 each), and 3 west coast trips ($633
each). Future years are inflated by 7% per year.

Other Expenses

Equipment and Software Maintenance

We budget $19,200 per year for community file server maintenance from DEC and
third party vendors and $1,350 for Diablo printers and miscellaneous equipment. We
budget $30,000 for Lisp machine maintenance. We have relatively little experience with
these machines out of warranty but are basing this estimate on partial coverage of time
and materials repairs. The contract maintenance prices for these workstations is so
high per machine and multi-machine discounts are not available that T&M is a more
cost-effective approach. The allocated amount provides for maintenance for 20
machines at an estimated $1,500 per machine per year average cost. We budget $1,800
for software lease costs for packages that are necessary and for which we cannot arrange
free access. We have budgeted a 7% per year increase for maintenance costs.

Telephone Services

We budget $13,100 for staff office telephones, and $4,000 for dataphone services for
local Stanford community dialup ports on the local network and home terminal
telephones for staff and some core research personnel to maximize productive working
hours (generally well in excess of 8 hours per day total). Again, these estimates are
based on the current configuration of lines and average monthly charges. We
periodically review these arrangements to maintain satisfactory service at minimum cost.
We anticipate annual increases to average 7%.

Auxiliary Computer Services

We budget $3,000 to cover service charges for AIM community use of other Stanford
campus computer resources that complement SUMEX facilities. These include partial
use of the Stanford Computer Science Department Dover printer, core research use of
the SCORE 2060 machine, and various services from the Stanford ITS facility. We
have budgeted 7% increase for each subsequent year.

Services and Documentation

$1,000 is budgeted for current documentation on system facilities and machines and
$2650 for technical books and publication expenses. $2,700 is budgeted for photo-

E. H. Shortliffe 12 Privileged Communication
Budget Explanation and Justification

reproduction and various technical services based on previous experience. Each
following year will reflect a 7% increase.

Prorated 2060 Operations Costs

As mentioned earlier, we plan to phase out DRR support for the DEC 2060 mainframe
resource over the S-year term of this grant. We plan to do this gradually and
responsibly so that our users can relocate to other facilities or move to workstation
environments for their research. For the first year we allocate $347,582 to the resource

budget, which is 80% of the estimated 2060 operating costs detailed in the following
section.

Privileged Communication 13 E. H. Shortliffe
Budget Explanation and Justification

1.3.2. 2060 Operations Budget

This section explains the details of the 2060 operations budget for the proposed five
year grant term. The figures in this section represent the total estimated 2060
operating costs. Only prorated shares of these costs are allocated to the resource budget
as we phase-out the 2060 from our operations in favor of the workstation technologies
we will be developing. The phasing is linear over 5 years with 80% of the 2060 costs
charged to the resource budget in renewal year 1 (grant year 14), 60% in year 2, 40% in
year 3, 20% in year 4, and 0% in year 5. As before, indirect costs are not shown in the
budget and will be awarded separately on the basis of Modified Total Direct Costs. The
indirect cost rate of 69%, is based on an agreement with the Office of Naval Research
(ONR) dated September 14, 1984.

Personnel

Mr. Rindfleisch (10%) and Mr. Yeager (10%) are responsible for overall 2060 facility
implementation and management. Ms. McCabe (25%) provides facility administrative
support.

The programming staff, Mr. Sweer (90%) and Mr. Gilmurray (30%) share joint
responsibility for system development and maintenance, user assistance, subsystem and
utility program development, and operational support. These duties include, for
example, performance analysis and improvement, bug correction, bringing up new
monitor releases, system communications support, special device drivers and diagnostics,
scheduler changes to control system allocation, and system maintenance. They also
share responsibility for the system software such as user utilities, languages, and network
utilities.

Mr. Tucker (80%) is responsible for network vendor interfaces and overseeing system
Operations and backup. He is assisted in providing file system archive and retrieval
service and backup dumps as well as system utility programming support by 3 students
(currently Blattel, Dolhert, and Jong). Ms. Ryalls (80%) acts as the system
administrator, providing both system and user support for the resource.

Mr. Nicholas Veizades (20%) and Mr. Israel Torres (20%) provide electronics support
for system maintenance, including special purpose, in-house designed hardware and
terminal and communications equipment.

Personnel estimates are again based on current salaries and are increased by 7% per
year for inflation. Staff benefits rates are the same as calculated for the main Tesource
budget.

Consultant

We do not plan any consulting support for the 2060 operations.

Equipment Purchase

We budget $6,000 for minor equipment purchases including communications equipment,
Ethernet interfaces, accessories, and other equipment replacements. This budget is
increased by 7% per year to accommodate inflation.

Supplies

Office supplies are budgeted at $920 based on past experience. Computer supplies are
budgeted at $8,000 projecting recent operating experience and including paper, ribbons,

E. H. Shortliffe 14 Privileged Communication
Budget Explanation and Justification

disks, tapes, labels, and other supplies needed for the computer facility. Engineering
supplies are budgeted at $1,500 to cover needed parts and spares for maintaining in-
house equipment. We have budgeted a 7% per year increase for all supplies.

Travel

The travel budget covers domestic travel for staff to technical meetings. We budget 1
east coast trip at $1,500. Future years are inflated by 7% per year.

Other Expenses

Equipment and Software Maintenance

The 2060 hardware system is covered on a DEC maintenance contract costing $92,300
per year. We also budget $3,950 for DEC software maintenance to keep up with the
latest releases and $6,800 for other software licenses, including NCPCALC, SPSS, and
SCRIBE. We have budgeted a 7% per year increase for maintenance costs.

Services and Documentation

$1,200 is budgeted for providing users with up-to-date documentation on system
facilities and subsystem programs. Substantial efforts continue. to upgrade
documentation for the user community. $625 is budgeted for technical books and
publication services. $825 is budgeted for photo-reproduction and technical services.
Each following year will reflect a 7% increase.

Telephone Services

We budget $2,935 for staff office telephones and $14,000 for dataphone services for
local Stanford community dialup ports on the SUMEX Computer and home terminal
telephones for staff to increase the hours they can work and facilitate their access to
the system at off hours when problems arise. These estimates are based on the current
configuration of lines and average monthly charges. We periodically review these
arrangements to maintain satisfactory service at minimum cost. We anticipate annual
increases to average 7%.

Network Communications Support

We budget $60,000 for continued TYMNET network services for remote SUMEX-AIM
users. This amount is estimated based on projections from current experience for
TYMNET services (including network interface lines, maintenance, and usage costs). In
past years, these funds have been distributed directly from NIH/BRTP through the
Rutgers University TYMNET contract so as to maximize the benefit of a volume
discount. This may still prove to be the most cost-effective approach and we will work
closely with NIH/BRTP to secure these important services at the lowest cost. We
include a 7% per year inflation rate.

The SUMEX-AIM ARPANET connection costs are being borne by ARPA Information
Processing Techniques Office in support of the Stanford Knowledge Systems Laboratory
basic AI research contract. We expect this relationship to continue and that NIH will
continue to benefit from this arrangement.

Privileged Communication 15 E. H. Shortliffe
Budget Explanation and Justification

1.4. Biographical Sketches

E. H. Shortliffe 16 Privileged Communication
E.H. Shortliffe
PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR:

BIOGRAPHICAL SKETCH

Give the following information for key professional personnel listed on page 2, beginning with the
Principal Investigator/Program Director. Photocopy this page for each person.

 

 

NAME TITLE BIRTHDATE (Mo., Day, Yr.
Edward H. Shortliffe Assoc. Prof. of Medicine 8/28/47

 

 

 

EDUCATION (8egin with baccalaureate or other initial professional education and include postdoctoral training}

DEGREE (eircie YEAR
highest degree) CONFERRED

 

INSTITUTION AND LOCATION FIELD OF STUDY

 

Harvard College, Cambridge, MA A.B. 1970 Applied Math & Comp.Sci
Stanford University School of Ph.D. 1975 Med. Inf. Science
Medicine, Stanford, CA M.D. 1976 Medicine

 

 

 

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present position, list in chronological order previous employment, experi-
ence, and honors. include present membership on any Federal Government Public Advisory Committee. List, in chronological order, the titles and
complete references to ail publications during the past three years and to representative earlier publications pertinent to this application. DO NOT
EXCEED TWO PAGES.

7/76 - 6/77 Intern in Medicine, Massachusetts General Hospital, Boston, MA

7/77 - 6/79 Resident in Medicine, Stanford University Medical Center, Stanford

7/79 - 2/85 Assistant Professor of Medicine, Stanford University School of Medicine

10/79 2/85 Assistant Professor of Computer Science (by courtesy), Stanford University

1/80 - 2/85 Co-principal Investigator and Medical Liaison, SUMEX-AIM Computing

Resource, Stanford University, Stanford, CA

3/85 - Associate Professor of Medicine, Stanford University School of Medicine
3/85 - Associate Professor of Computer Science (by courtesy), Stanford University
3/85 - Principal Investigator, SUMEX-AIM Computing Resource

Honors:

Editorial Boards: Medical Decision Making; Computer ae and Programs in Biomedicine:

ee |

Intelligence.
Research Career Development Award, NLM, 1979-1984

Henry J. Kaiser Family Foundation Faculty Scholar in General Internal Med., 1983-1986

Selected Publications

Shortliffe, E.H. Computer-Based Medical Consultations: MYCIN, Elsevier/ North Holland,
New York, 1976. Japanese language version by Bunkodo Blue Books,
Tokyo, 1981 (translated by T. Kaminuma).

Buchanan, B.G. and Shortliffe, E.H. Rule-Based Expert Systems: The MYCIN Experiments
of the Stanford Heuristic Programming Project. Reading,MA: Addison-~
Wesley, 1984.

Clancey, W.J. and Shortliffe, E.H. Readings in Medical Artificial Intelligence: The
First Decade. Reading, MA: “Addison-Wesley, 1984,

Shortliffe, E.H., Axline, $.G., Buchanan, B.G., Merigan, T.C., and Cohen, S.N. "An
artificial intelligence program to advise physicians regarding
antimicrobial therapy." Comput. Biomed. Res. 6:544-560 (1973).

Shortliffe, E.H. and Buchanan, B.G. "A model of inexact reasoning in medicine."

Math. Biosci. 23:351-379 (1975).

Shortliffe, E.H., Davis, R., Axline, S.G., Buchanan, B.G., Green, C.C., and Cohen, S.N.
"Computer-based consultations in clinical therapeutics: explanation
and rule-acquisition capabilities of the MYCIN system." Comour.
Biomed. Res. 8:303=-320 (1975).

Wraith, S.M., Aikins, J.S., Buchanan, B.G., Clancey, W.J., Davis, R., Fagan, L.M.,
Hannigan, J.F., Scott, A.C., Shortliffe, E.H., van Melle, W.J.,

Yu, V.L., Axline, $.G., and Cohen, S.N. "Computerized consultation
system for selection of antimicrobial therapy." Amer. J. Hosp. Pharm.
33:1304-1308 (1976).

 

 

PHS 398 (Rev. 5/82) pace __17
E.H. Shortliffe

Biographical Sketch - Edward H. Shortliffe (con't)

Davis, R., Buchanan, B.G., and Shortliffe, E.H. "Production rules as an approach to
knowledge-based consultation systems." Artificial Intelligence
8:15-45 (1977).
Scott, A.C., Clancey, W., Davis, R., and Shortliffe, E.H. "Explanation capabilities
of knowledge-based production systems." Amer. J. Computational
Linguistics, Microfiche 62, 1977.
Yu, V.L., Buchanan, B.G., Shortliffe, E.H., Wraith, S.M., Davis, R., Scott, A.C.,
Axline, S.G., and Cohen, S.N. "Evaluating the performance of a
Computer-based consultant.” Comput. Prog. Biomed. 9:95-102 (1979).
Shortliffe, E.H., Buchanan, B.G., and Feigenbaum, E.A. "Knowledge engineering for
medical decision making: A review of computer-based clinical decision
aids." Proceedings of the IEEE, 67:1207-1224 (1979).
Shortliffe, E.H. "The computer as clinical consultant" (editorial). Arch. Int. Med.
140:313=314 (1980).
Fagan, L.M., Shortliffe, E.H., and Buchanan, B.C. "Computer-based medical decision
making: from MYCIN to VM." Automedica 3:97-106 (1980).
Teach, R.L. and Shortliffe, E.H.. "An analysis of physician attitudes regarding
computer-based clinical consultation systems." Comput. Biomed. Res.
14:542-558 (1981).
Shortliffe, E.H. "The computer and clinical decision making: good advice is not
enough" (guest editorial). IEEE Engineering in Medicine and Biology
Magazine, 1(2):16-18 (1982).
Wallis, J. and Shortliffe, E.H. "Explanatory power for expert systems: studies in the
representation of causal relationships for medical consultation
systems." Meth. Info. Med., 21:127-136 (1982).
Gerring, P.E., Shortliffe, E.H., and van Melle, W. "The Interviewer/Reasoner model:
an approach to improving system responsiveness in interactive AI:
systems." AI Magazine 3(4):24-27 (1982).
Suwa, M., Scott, A.C., and Shortliffe, E.H. "An approach to verifying completeness
.and consistency in a rule-based expert system." AI Magazine 3(4):
16-21 (1982).
Duda, R.O. and Shortliffe, E.H. “Expert systems research." Science, 220(4594) : 261-268
(1983).
Aikins, J.S., Kunz, J.C., Shortliffe, E.H., and Fallat, R.J. "PUFF: An expert system
for interpretation of pulmonary function data." Comput. Biomed. Res.,
16:199=208 (1983).
Langlotz, C.P. and Shortliffe, E.H. "Adapting a medical consultation system to critique
physicians’ therapy plans." Int. J. Man-Machine Studs., 19:479-496
(1983). Reprinted in Developments in Expert Systems (M.J. Coombs, ed.)
pp. 77-94, London: Academic Press, 1984,
Kunz, J.C., Shortliffe, E.H., Buchanan, B.G., and Feigenbaum, E.A. "Computer-assisted
decision making in medicine." Journal of Philosophy and Medicine
9:135-160 (1984).
Shortliffe, E.H.' "Reasoning methods in medical consultation systems: artificial
intelligence approaches." Comput. Prog. Biomed., 18:5-14 (1984). °
Gordon, J. and Shortliffe, E.H. "A method for managing evidential reasoning in a
hierarchical hypothesis space." Accepted for publication in
Artificial Intelligence, Summer 1985.
Shortliffe, E.H. "Consultation systems for physicians: the role of artificial
intelligence techniques." Proceedings of the Third National Conference,
Canadian Society for Computational Studies of Intelligence, Victoria,
British Columbia, 14 May 1980. Also in Readings in Artificial

Intelligence. (B. Webber and N. Nilsson, eds.), Ticega Publishing Co.,
Menlo Park, CA, 1981.

3

18
PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR:
BIOGRAPHICAL SKETCH

E. H. Shortliffe

 

Give the following information for key professional personnel listed on Page 2, beginning with the
Principal Investigator/Program Director. Photocopy this page for each person.

 

 

 

 

 

 

NAME TITLE BIRTHDATE {Mo., Day, Yr/

FEIGENBAUM, Edward A. Professor, Computer Science January 20, 1936
EDUCATION (Begin with baccalaureate or other initial orofessional eaucation and include postdoctoral training)

OEGREE feircie YEAR FIELD OF sTUDY
INSTITUTION AND LOCATION highest degree! CONFERRED

‘Carnegie Institute of Technology,

Pittsburgh, Pennsylvania B.S. 1956 Electrical Enginee:
Carnegie Institute of Technology ;

Pittsburgh, Pennsylvania Ph.D. 1959 Industrial Admin.

 

 

 

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present Dasition, tist in chronotogical order previous empioyment, exc:
ence, and honors. Include present membership on any Federal Government Public Advisory Committee. List, in chronological order, the titles 2
complete references to ail publications during the past three years and to representative earlier publications pertinent to this applicatian. OO Ni

EXCEED TWO PAGES.
EXPERIENCE

University of California, Berkeley

Associate Professor, School of Business Administration, 1964-1965

Assistant Professor, School of Business Administration, 1960-63

Research Appointment, Center for Human Learning, 1961-64

Research Appointment, Center for Research in Management Science, 1960-64

Stanford University, Stanford, California

Professor of Computer Science, 1969-

Principal Investigator, Heuristic Programming Project, 1965-

Principal Investigator, SUMEX-AIM Project, national computer resource for application
of artificial intelligence to medicine and biology, 1978-1985

Chairman, Computer Science Department, 1976-1981

Associate Professor of Computer Science, 1965-68

Director, Stanford Computation Center, 1965-68

Professor (by Courtesy), Department of Psychology, 1976-

Member, Computer and Biomathematical Sciences Study Section, National Institutes of
Health, Bethesda, Md., 1968-72.

Member, Committee on Mathematics in the Social Sciences, Social Science Research
Council, New York, NY, 1977-78.

Member, Computer Science Advisory Committee, National Science Foundation, 1877-80
Member, Advisory Committee on Mathematics in Naval Research, NRC/ONR, 1979-82

Member, National Advisory Committee, University of Missouri Health Care Technology Center
(previous)

Member, Editorial Board, Journal of Artificial intelligence

Editor, Computer Science Series, McGraw-Hill Book Co., 1965-1979

President, American Association for Artificial Intelligence (AAAI), 1980-81

Member, Council of American Association for Artificial intelligence (AAAI), 1979-82
Member, Council of Cognitive Science Society, 1979-82

Member, DARPA Advisory Committee

PROFESSIONAL SOCIETIES

American Association for Artificial Intelligence (President, 1980-81)

Cognitive Science Society (Member, Governing Board, 1979-)

American Association for the Advancement of Science, (Fellow, 1983- )

Association for Computing Machinery (Member of National Council of ACM, 1966-68)
American College of Medical Informatics (Fellow, 1984- )

 

PHS 398 (Rev, 5/82) Pace 19
E. H. Shortliffe

CONSULTANTSHIPS

InteiliCorp
Sperry Corporation

BOOKS AND MONOGRAPHS

Feigenbaum, E.A., & McCorduck, P. (1983). The Fifth Generation: Artificial Intelligence and
Japan's Computer Challenge to the Worid. New York: Addison-Wesley

Barr, A. Cohen, P., & Feigenbaum, £.A. eds. (1881, 1982). Handbook of Artificial
Intelligence (Three Volumes). Los Altos, CA: Wm. Kaufmann inc.

Buchanan, B., Feigenbaum, E.A., Lindsay, R., & Lederberg, J. (1980) Applications of Artificial
Intelligence for Organic Chemistry: The DENDRAL Project. New York: McGraw-Hill.

Feigenbaum, E.A., & Feldman, J. eds. (1963). Computers and Thought. New York: McGraw-
Hill.

Feigenbaum, E.A., Newell, A. Tonge, F., Mealy, G., et al. (1961). Information Processing
Language V Manual. Englewood Cliffs, N.J.: Prentice-Hall.

Feigenbaum, E.A. (1959). An Information Processing Theory of Verbal Learning. Santa
Monica, The RAND Corporation Paper P-1817 (Monograph).

SOME RECENT AND SELECTED PAPERS

Feigenbaum, E.A., & Simon, H. (1984) EPAM-like Models of Recognition and Learning
Cognitive Science 8, 4 (Oct.-Dec.), 305-336.

Kunz, J., Feigenbaum, £.A., Buchanan, B., & Shortliffe, E.H. (1984). Comparison of
Techniques of Computer-Assisted Decision Making in Medicine. in Modeling and Analysis in
Biomedicine. Singapore: Worid Press. (335-367).

Kunz, J., Shortliffe, E.H., Buchanan, B.G., & Feigenbaum, E.A. (1984). Computer-Assisted
Decision Making in Medicine. Journal of Philosophy and Medicine, 9, (135-160).

Feigenbaum, E.A. (1984). Knowledge Engineering: The Applied Side of Artificial Intelligence.
In Annals of the New York Academy of Sciences, 426, (91-107).

Fagan, L.M., Kunz, J.C., Feigenbaum, E.A., & Osborn, J.J. (1979). Representation of Dynamic
Clinical Knowledge: Measurement Interpretation in the Intensive Care Unit. in Proceedings of
the Sixth international Joint Conference on Artificial Intelligence. Tokyo, Japan. (216-262).

Fagan, L.M., Kunz, J.C., & Feigenbaum, E.A. (1979). A Symbolic Processing Approach to
Measurement Interpretation in the Intensive Care Unit. In Proceedings of the Third Annual
Symposium on Computer Applications in Medical Care. Silver Spring, Maryland.

Fagan, L.M., Kunz, J.C., Feigenbaum, E.A., & Osborn, J.J. (1979). Knowledge Engineering for
Dynamic Clinical Settings: Giving Advice in the Intensive Care Unit. In Proceedings: of the
Sixth lJCAI 79, (260-262).

20
PRINCIPAL INVESTIGATOR/PROGRAM oIRECTOR: EH. Shortliffe

BIOGRAPHICAL SKETCH

Give the following information for key professional personnel listed on page 2, beginning with the
Principal Investigator/Program Director. Photocopy this page for each person.

 

NAME
RINDFLEISCH, Thomas C.

 

TITLE

Senior Research Associate/
Resource Director

 

BIRTHDATE {MMo., Day, Yr.)
December 10, 1941

 

EDUCATION (Begin with baccalaureate or other initial professional education and include postdoctoral training)

 

 

 

YEAR
INSTITUTION AND LOCATION ovheer dewreer CONFERRED FIELD OF STUDY
“Purdue University, Lafayette, Indiana B.S. 1962 Physics
California Institute of Technology, M.S. 1965 Physics
Pasadena Ph.D.

 

 

Thesis to be completed; all cour
work sod eximinations completes,

 

RESEARCH ANOD/OR PROFESSIONAL EXPERIENCE: Concluding with present position, list in chronological order previous employment, exper
ence, and honors. include present membership on any Federal Government Pubtic Advisory Committee. List, in chronological order, the titles ar
complete references to al! publications during the past three years and to representative earlier publications pertinent to this application. 00 NO

EXCEED TWO PAGES.

Stanford University:

1985 - present Senior Research Associate/Director, Knowledge Systems Laboratory
(KSL), Department of Computer Science, and Director, Symbolic
Systems Resources Group (SSRG), including SUMEX, Department of
Medicine

1982 - 1985 Senior Research Associate/Director, Heuristic Programming Project
(HPP), Department of Computer Science

1976 - 1982 Senior Research Associate/Director, SUMEX Computer Resource,
Departments of Medicine and Computer Science

1974 - 1976 Research Associate/Director, SUMEX Computer Project, Departments
of Medicine and Computer Science

1971 - 1976 | Research Associate, DENDRAL Project, Department of Genetics

Jet Propulsion Laboratory, California Institute of Technology, Pasadena:

1969 - 1971 Supervisor of Image Processing Development and Applications Group
1968 - 1969 Mariner Mars 1969 Cognizant Engineer for Image Processing
1962 - 1968 Engineer, design and implement image processing computer software

PUBLICATIONS (see attached sheet)

 

PHS 398 (Rev. 5/82)

PAGE ste
Publications:

1.

10.

Rindfleisch, T. and Willingham, D., "A Figure of Merit Measuring Picture Resolution,” JPL
Technical report 32-666, September 1965.

Rindfleisch, T. and Willingham, D., "A Figure of Merit Measuring Picture Resolution,”
Advances in Electronics and Electron Physics, Volume 22A, Photo-Electronic image
Devices, Academic Press, 1966.

Rindfleisch, T., "A Photometric Method for Deriving Lunar Topographic Information,” JPL
Technical Report 32-786, September 1965.

Rindfleisch, T., "Photometric Method for Lunar Topography," Photogrammetric
Engineering, March 1966.

Rindfleisch, T., “Generalizations and Limitations of Photoclinometry," JPL Space Science
Summary, Volume lll, 1967.

Rindfleisch, T., "The Digital Removal of Noise from Imagery," JPL Space Science
Summary 37-62, Volume Ili, 1970.

Rindfleisch, T., "Digital Image Processing for the Rectification of Television Camera
Distortions," Astronomical Use of Television Type Image Sensors, NASA Special
Publication SP-256, 1971.

Rindfleisch, T., Dunne, J., Frieden, H., Stromberg, W., and Ruiz, R., “Digital Processing of
the Mariner 6 and 7 Pictures,” Journal of Geophysical Research, Volume 76, Number 2,
January 1971.

Pereira, W. E., Summons, R. E., Reynolds, W. E., Rindfleisch, T. C. and Duffield, A. M.,
"The Quantitation of Beta-Aminoisobutyric Acid in Urine by Mass Fragmentography,"”
Clinica Chimica Acta, 49, 1973.

Summons, R. E., Pereira, W. E., Reynolds, W. £., Rindfleisch, T. C., and Duffield, A. M.,

_"Analysis of Twelve Amino Acids in Biological Fluids by Mass Fragmentography,”

11.

12.

13.

14,

15.

16.

Analytical Chemistry, Vol. 46, No. 4, April 1974.

Pereira, W. E., Summons, R. E., Rindfleisch, T. C., and Duffield, A. M., "The Determination
of Ethano! in Blood and Urine by Mass Fragmentography,” Clin. Chim. Acta, 51, 1974.

Pereira, W.£., Summons, R.E., Rindfleisch, T. C., Duffield, A.M., Zeitman, B., and
Lawless, J. G., "Stable Isotope Mass Fragmentography: Quantitation and Hydrogen-
Deuterium Exchange Studies of Eight Murchison Meteorite Amino Acids," Geochem. et
Cosmochim. Acta, 39, 163, 1975.

Dromey, R. G., Stefik, M. J., Rindfleisch, T. C., and Duffield, A. M., “Extraction of Mass
Spectra Free of Background and Neighboring Component Contributions from Gas
Chromatography/Mass Spectrometry Data", Analytical Chemistry, 48, page 1368, 1976.

Smith, D.H., Yeager, W.J., Anderson, P. J., Fitch, W.L., Rindfleisch, T.C., and
Achenbach, M., “Historical Library Search. An Approach to Quantitative Comparison of
GC/MS Profiles of Complex Mixtures," Analytical Chemistry, 49, page 1623, 1977.

Rindfleisch, T. C., Smith, D.H., Yeager, W. J., Achenbach, M, W., and Wegmann, A.,
“Advances in Data Acquisition and Analysis Systems for Applications of Gas
Chromatography/Mass Spectrometry," in Biomedical Applications of Mass Spectrometry
(First Supplementary Volume), edited by G. R. Wailer and O. C. Dermer, page 55, John
Wiley & Sons, New York, 1980. ;

Feigenbaum, E. A., Brown, H., Delagi, B. A., Gabriel, R. P., Nii, H. P., and Rindfleisch,
T.C., “Advanced Architectures Project: Scope and Approach," Stanford Heuristic
Programming Project Report HPP-84-40, October 1984.

22
PRINCIPAL INVESTIGATOR/PROGRAM Director: £-H. Shortliffe
BIOGRAPHICAL SKETCH

Give the following information for key professional personnel listed on page 2, beginning with the
Principal Investigator/Program Director. Photocopy this page for each person.

 

NAME TITLE BIRTHDATE (Ma., Day, Yr.
Systems Programmer/Assistant

T 8 7

YEAGER, William J Director June 16, 1940

 

 

 

EDUCATION (Begin with baccalaureate or other initial professional education and include postdoctoral training!

DEGREE (circle YEAR
highest degree} CONFERRED

 

INSTITUTION AND LOCATION FIELD OF STUDY

 

University of California, Berkeley B.A. 1964 Mathematics
California State University, San Jose M.A. 1967 Mathematics
University of Washington, Seattle None -- Mathematics

Dectoral studies (1969-70)

 

 

 

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present position, list in chronological order previous employment, exper:
ence, and honors. include present membership on any Federal Government Public Advisory Committee. List, in chronological order, the titles an:
complete references to ali publications during the past three years and to representative earlier publications pertinent to this application. DO NO~
EXCEED TWO PAGES.

1985 - present Assistant Director, SUMEX Computer Project, Department of Medicine,
Stanford University

1978 - 1985 Systems Programmer, SUMEX Computer Project, Department of Medicine,
Stanford University

1975 = 1978 Scientific Programmer, Instrumentation Research Laboratories, Department
of Genetics, Stanford University

1971 - 1975 Programmer, Bendix Field Engineering, Moffett Field, California

1970 - 1971 Programmer, WELLSCO Data Corp., San Francisco, California

1968 - 1969 Mathematics Instructor, Gavilan Jr. College, Gilroy, California

1967 ~- 1968 Mathematics Instructor, California Western Univ., San Diego

1966 - 1967 Mathematician/Programmer, Applied Physics Laboratory,
Seattle, Washington

1966 Systems Representative, Burroughs Corp., San Jose, California

PUBLICATIONS Technical Report (Pending): Yeager, W.J.: "Ether TIPs and
Gateways at SUMEX."

 

PHS 398 (Rev. 5/82) PAGE _23_-
| NAME

JACOBS, Charlotte

PRINCIPAL INVESTIGATOR PSICGAAM DIRECTCR: _“°

BIOGRAPHICAL SKETCH

. Shortliffe

Give the following information far key professional personnel listed on page 2, beginning with the

Principal Investigator/Program Director. Photocopy this Page for each person,
BIRTHDATE (Mo., Day, r./

January 27, 1946

TITLE
Asst Prof of Medicine

 

 

EDUCATION (8eain with baccalaureate or acher initial brotessional education and inciude Bostdoctoral training)

 

 

 

 

 

INSTITUTION AND LOCATION imho demeas | CONFERED FIELD OF sTUDY
University of Rochester, Rochester, NY B.A. 1968 Biology
Washington University School of Medicine, M.D. 1972

St. Louis, MO Int,dr Res,| 1972 - 1974 Medicine
Univ of Ca, San Francisco, San Francisco,CA Sr Res 1974 - 1975 Medicine
stanford Univ, Stanford, CA 94305 Fellow 1975 - 1977 Oncology

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Canctuaing with present Dasition, list in chronological order previous empioyment, exper
ence, and honors. Include present membersnip on any Federal Government Public Advisory Committee. List, in chronoiogeal order, the uties an:
compiete references to all pubjications during the past three years and to representative eartier Bublications pertinent ta this application. OO NO?

POSITIONS “S**-

1977 - 1980

1977 - Present

1980 - Present

Acting Assistant Professor, Department of Medicine, Division of Medical
Oncology, Stanford University Medical Center, Stanford, CA

Director, Oncology Day Care Center, Department of Medicine, Stanford
University Medical Center, Stanford, CA

Assistant Professor, Department of Medicine, Division of Medical
Oncology, Stanford University Viedical Center, Stanford, CA

OTHER EXPERIENCE

Drug Advisory Board, FDA (1984 - 1986)

Head and Neck Intergroup, Chairman (1984 - 1986)
Faculty Senate (1984 - 1986)

HONORS
Phi Beta Kappa
Alpha Omega Alpha
Kaiser Award for Excellence
in Teaching (1983, 1985)
American Cancer Society
Junior Faculty Clinical Fellowship (1981)
Janet Glasgow Scholastic Citation Award of the
American Medical Women's Association (1972)
Missouri State Medical Association Award (1972)
Medical Alumni Scholarship Award (1971)
Lange Medical Book Awards (1969, 1970)
Janet Park Howell Award in Science (1968)

PUBLICATIONS
l.

Jacobs C, Portlock CS, Rosenberg SA. Prednisone in WOPP chemotherapy for Hodgkin's

disease. Br Med J 1976; 2:1469-1471.

2. Kim H, Jacobs C, Warnke RA, Dorfman RF. Mali

epitheloid histiocytes. Cancer 1978; 41:620-635,

3. Jacobs C, Bertino JR, Goffinet DR, Fee WE, Goode RL. Cis-
head and neck cancers. Otolaryngol! Head and

4, Jacobs C, Bertino JR, Goffinet DR, Fee WE, G

. head and neck cancers. Cancer 1978; 42:2135.
3. Jacobs C. Hodgkin's disease - a patient teaching tool.

6. Jacobs C. The role of cisplatin in the treatment of rec

Cisplatin Current Status and New Developments.

Carter SK. Academic Press, 1980; 423-430.

2140.

gnant lymphoma with a high content of

platinum chemotherapy in
Neck Surg 1978; 86:780-783, .
oode RL. 24-hour infusion of cis-platinum in

Cancer Nursing 1979; 86:780-783.
urrent head and neck cancer.
Edited by Prestayko AW, Crooke ST,

 

PHS 398 (Rev. 5,82)

PAGE 24
DO NOT TYPE IN THIS SPACE—BINDING MARGIN

 

PRINCIPAL INVESTIGATOR/PROGAAM DIRECTOR OR AWARD CANDIDATE (Lasr, first. miacie) SOCIAL SECURITY NUMBEA

E. H. Shortliffe

 

 

7.

10.
ll.

12.

13.
14,
15.

16.

17.

13.
19.
20.
21.

22.

23.

24,

25.

26.
27.

28.

Levi J, Jacobs C, Kalman SM, McTigue M, Weiner MW. Mechanism of cis-platinum
nephrotoxicity: [. Effects on sulfhydryl! groups in rat kidneys. J Pharmacol Exp Ther 1980;
213:545-550.

Dobyan DC, Levi J, Jacobs C, Kosek J, Weiner MW. Mechanism of cis-platinum
nephrotoxicity: II. Morphologic observations. J Pharmacol Exp Therap 1980; 213:551-556.

Jacobs C, Kalman SM, Tretton M, Weiner MW. Renal handling of cis-

diamminedichloroplatinum (II) Cancer Treat Rep 1980; 64:1223-1226,

Jacobs C. High-dose methotrexate and cis-platinum in the treatment of recurrent head
and neck cancer. Recent Results Cancer Res 1981; 76:290-295.

Jacobs C, Donaldson SS, Rosenberg SA, Kaplan HS. Management of the pregnant patient
with Hodgkin's disease. Ann Intern Med 1981; 95:669-675.

Jacobs C, Ross R. The psychological assessment of cancer patients. Recent Advances in
Clinical Oncology. Edited by Williams CJ, Whitehouse JMA. Churchill Livingstone, 1982;
365-374,

Mead G, Jacobs C. The changing role of chemotherapy in the management of head and
neck cancer. Am J Med 1982; 73:582-595.

Jacobs C. Chemotherapy and combined modality treatment of head and neck cancer.
Current Concepts in Oncology, Vol 4, No. 3, 1982,

Jacobs C. The use of methotrexate + 5-fluorouracil for recurrent head and neck cancer.
Cancer Treat Rep 1982; 66:1925-1928, ,

Jacobs C, Ross R, Walker I, Stockdale FE. Behavior of cancer patients: A randomized
study of the effects of education and peer support groups. Am J Clin Oncol 1983; 6:347-
350.

Jacobs C, Meyers F, Hendrickson C, Kohler M, Carter S. A randomized phase III study of
cisplatin with or without methotrexate for recurrent squamous Cell carcinoma of the head
and neck. Cancer 1983; 52:1563-1569.

Weiner MW, Jacobs C. Mechanism of cisplatin nephrotoxicity. Fed Proc 1983; 42:2974-
2978.

Campbell AB, Kalman S, Jacobs C. Plasma platinum levels: Relationship to cisplatin dose
and nephrotoxicity. Cancer Treat Rep 1983; 67 (2):169-172.

Coleman CN, Friedman MK, Jacobs C et al. Phase I trial of intravenous Melphalan plus the
sensitizer Misonidazole. Cancer Res 1983; 43:5022-5025.

Jacobs C. The use of chemotherapy in the combination with radiotherapy in the treatment
of head and neck squamous cancers. Advances in Treatment and Research. Edited by Wolf
GT. Martinus Nijhoff Publishers, Boston, MA, 1984:265-286.

Jacobs C, Coleman CN, Rich L, Hirst K, Weiner MW. Inhibition of cisplatin secretion by
the human kidney with probenecid. Cancer Res 19843 44:3632-3635,

Jacobs C. The biophysiology of antineoplastic chemotherapy for head and neck cancers.
Otolaryngology/Head and Neck Surgery. Edited by Cummings, Frederickson, Harker,
Krause, Schuller. C.V. Mosby Company, St. Louis, MO 1985 (In press).

Shortliffe EH, Scott AC, Bischoff MD, Campbell AB, van Melje W, Jacobs C. An expert
system for oncology protocol management. Rule-Based Expert Systems. The Mycin
Experiments of the Stanford Heuristic Programming Project. Edited by Buchanan BG,
Shortliffe EH. Addison-Wesley Company, Menlo Park, CA 1984:653-655,

Schreiber D, Jacobs C, Rosenberg SA, Cox R, Hoppe RT. The potential benefits of
therapeutic splenectomy in Hodgkin's disease and non-Hodgkin's lymphomas. Int J Oncol
Biol Phys 1984; 11:31-36.

Jacobs C, Hoppe RT. Non-Hodgkin's lymphomas of the head and neck extranodal sites. Int
J Radiat Oncol Biol Phys 1984; 11:357-364, ;
Jacobs C. The role of chemotherapy in the treatment of head and neck cancer. Cisplatin
Current Status and New Developments. Academic Press, 1985 (In Press).

Connors JM, Andiman WA, Howarth CB, Liu E, Merigan TC, Savage ME, Jacobs C.
Treatment of nasopharyngeal carcinoma with human leukocyte interferon. J Clin Oncol
1985 (In Press).

 

PHS 398 (Rev. 5/82) PAGE_29_