Columbia Anibversity College of Physicians and Surgeons 630 WEST 168TH STREET NEW YORK 32, N. Y. DEPARTMENT OF BIOCHEMISTRY a” tee October 16, 1956 Dr. Joshua Lederberg Department of Genetics University of Wisconsin Madison 6, Wisconsin Dear Dr. Lederberg: I, of course, read with interest your recent paper on the adaptive enzyme forming protoplasts from Kj9. I wonder if you have tried inducing the protoplasts with ultraviolet for lambda formation? If you have and were unsuccessful, I would be saved a lot of time. Thank you for the two slants which arrived. Has anything developed on the histidineless mutants? I am sorry that my young lady associate, Miss Rockenbach, decided--despite my urgings-