BIOGRAPHICAL SKETCHES

II. RESEARCH PLAN - BOOK II

This is an application for renewal of a grant supporting the Stanford
University Medical EXperimental computer (SUMEX) research resource for
applications of Artificial Intelligence in Medicine (AIM). The research plan has
been divided into several logical parts:

1) Book I - Resource research objectives and rationale, progress report, and
detailed research plans.

2) Book II ~ Biographical sketches, collaborating project reports and plans,
and supporting appendixes.

3) Budget - First year budget detail, five-year budget summary, and budget
explanation and justification.

5 BIOGRAPHICAL SKETCHES

The following are biographical sketches for all professional personnel
contributing to the SUMEX-AIM resource project. These do not include sketches
for individual collaborating project investigators.

Privileged Communication 1 J. Lederberg
SECTION Il ~ PRIVILEGED COMMUNICATION
BIOGRAPHICAL SKETCH

(Giva the following information for all professional personnal listed on pega 3, begianirg with the Principal Investiontor.
Use continuation pagas and fallow ths same genarst format for sach person}

TAME TITLE ~~ [BIATHDATE (Ma, Day, Yn)

Professor and Chairman
FEIGE :
E NBAUM, Edward A Computer Science Department January 20, 1936

PLACE OF BIRTH [City, Siete, Country) . PRESENT NATIONALITY {/f non-U.S. citizen, SEX
indicate kind of visa and eapiration dats}

 

 

 

 

 

 

 

 

 

 

 

 

Weehawken, New Jersey, U.S.A. U.S. citizen [3 Mata (1 Femata
EDUCATION (3agin with baccalauraata training und includs postdcctoral}
eeece EAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERRED FIELD
Carnegie Institute of Technology, B.S. 1956 Electrical Engineering
Pittsburgh, Pennsylvania ;
Carnegie Institute of Technology, Ph.D. “1959 Industrial .
Pittsburgh, Pennsylvania Administration
HONORS
MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT
Artificial Intelligence Co-Investigator

 

 

RESEARCH SUPPOAT (See instructions)

(See continuation page.)

 

RESEARCH AND/OR PAOFESSIONAL EXPERIENCE (Sarrtirg with present position, List trining and axpariance relevant to arsa of project, List ail
or most representative publications, Do not exceed 3 pages for cach individual.)

1976 - present Professor (by Courtesy) Department of Psychology, Stanford University
1976 - present Chairman, Department of Computer Science, Stanford University
1969 - present Professor of Computer Science, Stanford University

1965 - 1968 Associate Professor of Computer Science, Stanford University

1965 - 1968 Director, Stanford Computation Center, Stanford University

1964 - 1965 Associate Professor, School of Business Administration,
University of California, Berkeley

1960 - 1963 Assistant Professor, School of Business Administration,
University of California, Berkeley

1961 - 1964 Research Appointment, Center for Human Learning,
University of California, Berkeley

1960 - 1964 Research Appointment, Center for Research in Management Science,

University of California, Berkeley
1965 - present Editor, Computer Science Series, McGraw-Hill Book Company, New York
1968 - 1972 Member, Computer and Biomathematical Sciences Study Section, NIH

Professional Societies: American Psychological Association, American Association for the

Advancement of Science, Association for Computing Machinery (member,
National Council of ACM, 1966-68)

Consultantships: Information. Sciences Institute, University of Southern California;
The RAND Corporation; System Development Corporation (knowledge-based
systems project); Systems Control, Inc. (HASP project)

PUBLICATIONS (See continuation page.)

HIH 399 (FORMERLY PHS 393)
Rav. 1/73

2 U, S. COVERNMENT PRINTTIG OFFICE : 1974 384-250/2004
Privileged Communication

Joshua LEDERBERG

BIOGRAPHICAL SKETCH - FEIGENBAUM, Edward A.

RESEARCH SUPPORT

1.

Contract No.:
Title of Project:
Grant Agency:

a. Project Period:
Annual Funding:
% of Effort:

b. Proposed Renewal:

Annual Funding:
% of Effort:

Grant No.:
Title of Project:

Project Period:
Annual Funding:
% of Effort:
Grant Agency:

Grant No.:
Title of Project:

Project Period:
Annual Funding:
% of Effort:
Grant Agency:

Grant No.:
Title of Project:

Project Period:
Annual Funding:
% of Effort:
urant Azency:

Proposal Submitted:

Title of Project:

Project Period:
Annual Funding:
% of Effort:
Grant Agency:

DAHC-15~-7 3-C-0435
Heuristic Progranning Projeat

ARPA
1/73 - T/TT
$ 225,762

90% summer, 49% academic year

8/77 ~ 9/79

$ 375,000 (8/77-9/78), $ 350,000 (10/78-9/79)
33% summer 1977, 17% academic year 1977-78,
100% summer 1978, 18% academic year 1978-79

RR-00612
Resource Helat
Computers and
5/T7T =~ 4/89

$ 218,580 (5/77-4/738) (Direct Costs)
5% (no salary)

NIA

ed Research -
Chemistry (DENDRAL)

MCS 74-23451

Automation of Seientifie Inference:
Heuristic Computing Applied to
Protein Crystallography

2/75 - 4/79 + 6 mos.

& 75,000

5% (no salary)

NSF

MCS 76~11649

MOLGEN: A Computer Science Application
to Molecular Genetics

6/76 ~ 5/73 + 5 mos.

$ 55,350
10% acadenia year, 100% summer (2 mos. 1977)
NSF

Biomedical Knowledge Engineering
in Clinical Hedicine

1/78 = 12/89

$ 170,879 (Direct Costs)

10% (no salary)

NIH (subcontract)
Privileged Communication Joshua LEDERBERG
BIOGRAPHICAL SKETCH - FEIGENBAUM, Edward A.

PUBLICATIONS

Books and Monographs:

Computers and Thought, co-editor with Julian Feldman, McGraw-Hill,
1963.

Information Processing Language V Manual, Englewood Cliffs, N.J.,
Prentice-Hall, 1961 (with A. Newell, F. Tonge, G. Mealy, et.al.).

An Information Processing Theory of Verbal Learning, Santa Monica,
The RAND Corporation Paper P-1817, October 1959 (Monograph).

Papers (1965-present):
(List organized by topic)

Heuristic DENDRAL Project:

(1) J. Lederberg and E. A. Feigenbaum, "Mechanization of Inductive
Inference in Organic Chemistry", in B. Kleinmuntz (ed), Formal
Representations for Human Judgment, (Wiley, 1968). (Also Stanford
Artificial Intelligence Project Memo No. 54, August 1967).

(2) E. A. Feigenbaum and B. G. Buchanan, "Heuristic DENDRAL: A
Program for Generating Explanatory Hypotheses in Organic Chemistry",
in Proceedings, Hawaii International Conference on System Sciences,
B. K. Kinariwala and F. F. Kuo (eds), University of Hawaii Press, 1968.

(3) B. G. Buchanan, G. L. Sutherland, and E. A. Feigenbaum, "Heuristic
DENDRAL: A Program for Generating Explanatory Hypotheses in Organic
Chemistry". In Machine Intelligence 4 (B. Meltzer and D. Michie, eds)
Edinburgh University Press (1969). (Also Stanford Artificial
Intelligence Project Memo No. 62, July 1968.)

(4) E. A. Feigenbaum, "Artificial Intelligence: Themes in the
Second Decade". In Final Supplement to Proceedings of the IFIP 68
International Congress, Edinburgh, August 1968. (Also Stanford
Artificial Intelligence Project Memo No. 67, August 1968.)

(5) J. Lederberg, G. L. Sutherland, B. G. Buchanan, E. A. Feigenbaun,
A. V. Robertson, A. M. Duffield, and C. Djerassi, "Applications of
Artificial Intelligence for Chemical Inference I. The Number of
Possible Organic Compounds: Acyclic Structures Containing C, H, 0

and N", Journal of the American Chemical Society, 91:11 (May 21,
1969).

(6) A. M. Duffield, A. V. Robertson, C. Djerassi, B. G. Buchanan,
G. L. Sutherland, E. A. Feigenbaum, and J. Lederberg, "Applications
of Artificial Intelligence for Chemical Inference Il. Interpretation
of Low Resolution Mass Spectra of Ketones". Journal of the American
Chemical Society, 91:11 (May 21, 1969).
Privileged Communication . Joshua LEDERBERG
BIOGRAPHICAL SKETCH —- FEIGENBAUM, Edward A.

Publications (continued)

(7) B. G. Buchanan, G. L. Sutherland, E. A. Feigenbaum, "Toward an
Understanding of Information Processes of Scientific Inference in
the Context of Organic Chemistry", in Machine Intelligence 5,

(B. Meltzer and D. Michie, eds) Edinburgh University Press (1970).
(Also Stanford Artificial Intelligence Project Memo No. 99, September
1969.)

(8) J. Lederberg, G. L. Sutherland, B. G. Buchanan, and E. A.
Feigenbaum, "A Heuristic Program for Solving a Scientific Inference
Problem: Summary of Motivation and Implementation", Stanford
Artificial Intelligence Project Memo No. 104, November, 1969.

(9) G. Schroll, A. M. Duffield, C. Djerassi, B. G. Buchanan, G. L.
Sutherland, E. A. Feigenbaum, and J. Lederberg, “Applications of
Artificial Intelligence for Chemical Inference III. Aliphatic Ethers
Diagnosed by Their Low Resolution Mass Spectra and NMR Data".

Journal of the American Chemical Society, 91:26 Wecember 17, 1969).

(10) A. Buchs, A. M. Duffield, G. Schroll, C. Djerassi, A. B. Delfino,
B. G. Buchanan, G. L. Sutherland, E. A. Feigenbaum, and J. Lederberg,
"Applications of Artificial Intelligence for Chemical Inference IV.
Saturated Amines Diagnosed by Their Low Resolution Mass Spectra and

Nuclear Magnetic Resonance Spectra", Journal of the American Chemical
Society, 92 (1970), 6831.

(11) Y. M. Sheikh, A. Buchs, A. B. Delfino, G. Schroll, A. M. Duffield,
C. Djerassi, B. G. Buchanan, G. L. Sutherland, E. A. Feigenbaum and
J. Lederberg, "Applications of Artificial Intelligence for Chemical
Inference V. An Approach to the Computer Generation of Cyclic
Structures. Differentiation Between All the Possible Isomeric
Ketones of Composition C6H100", Organic Mass Spectrometry, 4 (1970),
493.

(12) A. Buchs, A. B. Delfino, A. M. Duffield, C. Djerassi,
B. G. Buchanan, E. A. Feigenbaum and J. Lederberg, "Applications of
Artificial Intelligence for Chemical Inference VI. Approach to a
General Method of Interpreting Low Resolution Mass Spectra with a
Computer", Chem. Acta Helvetica, 53 (1970), 1394.

(13) E. A. Feigenbaum, B. G. Buchanan, and J. Lederberg, "On Generality
and Problem Solving: A Case Study Using the DENDRAL Program". In
Machine Intelligence 6 (B. Meltzer and D. Michie, eds.) Edinburgh
University Press (1971). (Also Stanford Artificial Intelligence
Project Memo No. 131.)

(14) A. Buchs, A. B. Delfino, C. Djerassi, A. M. Duffield,
B. G. Buchanan, E. A. Feigenbaum, J. Lederberg, G. Schroll, and
G. L. Sutherland, "The Application of Artificial Intelligence in the
Interpretation of Low-Resolution Mass Spectra", Advances in Mass
Spectrometry, 5, 314.
Privileged Communication Joshua LEDERBERG
BIOGRAPHICAL SKETCH — FEIGENBAUM, Edward A.

Publications (continued)

(15) B. G. Buchanan, E. A. Feigenbaum, and J. Lederberg, "A Heuristic
Programming Study of Theory Formation in Science." In proceedings of
the Second International Joint Conference on Artificial Intelligence,
Imperial College, London (September, 1971). (Also Stanford Artificial
Intelligence Project Memo No. 145.)

(16) D. H. Smith, B. G. Buchanan, R. S. Engelmore, A. M. Duffield,
A. Yeo, E. A. Feigenbaum, J. Lederberg, and C. Djerassi, "Applications
of Artificial Intelligence for Chemical Inference VIII. An Approach
to the Computer Interpretation of the High Resolution Mass Spectra of
Complex Molecules. Structure Elucidation of Estrogenic Steroids",
Journal of the American Chemical Society, 94 (1972), 5962-5971.

(17) B. G. Buchanan, E. A. Feigenbaum, and N. S. Sridharan, “Heuristic
Theory Formation: Data Interpretation and Rule Formation". In
Machine Intelligence 7, Edinburgh University Press (1973).

(18) D. H. Smith, B. G. Buchanan, W. C. White, E. A. Feigenbaun,
C. Djerassi and J. Lederberg, "Applications of Artificial Intelligence
for Chemical Inference X. Intsum. A Data Interpretation Program as
Applied to the Collected Mass Spectra of Estrogenic Steroids." ,
Tetrahedron, 29, 3117 (1973).

(19) E. A. Feigenbaum, "Computer Applications: Introductory
Remarks," in "Proceedings of Federation of American Societies
for Experimental Biology," 33, 2331 (1974).

(20) B. G. Buchanan, D. H. Smith, W. C. White, R. Gritter,
E. A. Feigenbaum, J. Lederberg and C. Djerassi, "Applications of
Artificial Intelligence for Chemical Inference. XXII. Automatic
Rule Formation in Mass Spectrometry by Means of the Meta-DENDRAL
Program." Journal of the American Chemical Society, 98:6168, (1976).

(21) E. A. Feigenbaum, R. S. Engelmore, and C. K. Johnson,
"A Correlation between Crystallographic Computing and Artificial
Intelligence Research," Acta Cryst. A33 (Jan 1):13-18, (1977).

(22) H. Penny Nii and Edward A. Feigenbaum, "Rule-based Understanding of
Signals," to be presented at Workshop on Pattern-directed Inference
Systems, (May 1977).
Privileged Communication Joshua LEDERBERG
BIOGRAPHICAL SKETCH — FEIGENBAUM, Edward A.

Publications (continued)

Information Processing Model Building in Psychology:

(1) "Information Processing" in Readiness to Remember: Proceedings
of the Third Conference on Remembering, Learning, and Forgetting,
Gordon and Breach (1972).

(2) "Information Processing and Memory," Proceedings of the Fifth
Berkeley Symposium on Mathematical Statistics and Probability,
Volume 4 (Biology and Health), University of California Press, 1967.
Reprinted in Norman, D. (ed.) Models for Memory, Academic Press (1971).

IFIP Congresses:

(1) Invited speech: “Artificial Intelligence: Themes in the Second
Decade." In Final Supplement to Proceedings of the IFIP 68 Congress,

Edinburgh, August, 1968. Aliso available as A.I. Project Working Paper
No. 67, August 1968.

(2) Report on Panel on the Mechanization of Creative Processes. In

Kalenich, W. (ed.), Proceedings of IFIP Congress 65, Volume 2, Spartan
Books, 1966, pp. 600-601.

Stanford Computation Center:

“Computers at Stanford," (with N. Nielsen). In Stanford Annual
Financial Report Summary, Stanford University, November 1967.
Reprinted in IBM Computing Report, Vol. IV, No. 3 (May, 1968), 15-18.

Other:

"Soviet Computer Science, Revisited." Proceedings of the 20th ACM
National Conference, August, 1965, pp. 225-226.

Papers, Pre-1965: Available upon request.
SECTION N — PRIVILEGED COMMUNICATION
. BIOGRAPHICAL SKETCH

(Givs the following information for oll professional personnal listed on page 3, beginning with the Principal Investigator,

 

tke continuation pages and follow the same general format for each parson}

 

 

 

 

 

 

 

 

 

 

 

NAME ‘ TITLE BIRTHDATE (Ma, Day, Yr]
JIRAK, Gregory A. System Programmer April 24, 1951
PLACE OF SIRTH (City, Stats, Country) PRESENT NATIONALITY (If n9n-U.S. citizen, SEX "
. indicats kind of visa and expiration cats)
Flagstaff, Arizona, U.S.A. U.S. citizen CUsie Cl remats
EDUCATION [32gin with baccalaureate training and inctuda postdoctoral) —
—— par "YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERAED FIELD
California Institute of Technology, B.S. 1974 Mathematics
Pasadena . (Information Science)
HONORS
MAJOA RESEARCH INTEREST ROLE IN PROPOSED PROJECT
Computer systems design System Programmer, MAINSAIL

 

 

RESEARCH SUPPORT (See instructions) —

 

RESEARCH ANDJOR PROFESSIONAL EXPERIENCE {Seartirg with present position, fist teyining and experiance ratev3nt ta ares of project, List ail
or most representative publications, Do not exceed 3 pages for cach individual.)

1976 — present System Programmer, MAINSAIL, SUMEX Computer Project,
Department of Genetics, Stanford University

1974 - 1976 Scientific Programmer, DENDRAL Project,
Instrumentation Research Laboratories,
Department of Genetics, Stanford University

1973 -~ 1974 Software Engineer, Image Processing Laboratory,
Jet Propulsion Laboratory, California Institute of Technology

1971 - 1973 Systems Programmer, Rapidly Extensible Language Project,
California Institute of Technology

e

1970 ~- 1971 Electronic Technician, Sound Master, Inc., Tempe, Arizona

1970 System Programmer, IBM 360/25 DOS, Curtis, Woodman & Roach, Inc.,
Yuma, Arizona

1968 — 1969 Junior Programmer, IBM 1401, Data Processing Center, Inc., Yuma, Arizona

PUBLICATIONS (none)

 

NIH 393 (FORMERLY PHS 398) 7
Ray. 1/73

# U.S. COYERNMENT PRINTING OFFICE : 1974 sa4-050/2036
SECTION H — PAIVILEGED COMMUNICATION

BIOGRAPHICAL SKETCH

{Give tha following information for ail professional parsonnal listed on pags 3, beginning with the Principal Inv=stigator.
Use continuation pogas and follow ths me gensril format far seach person}

 

 

 

 

 

 

 

NAME TITLE BIRTHDATE (Ma, Bay, ¥rJ
JOHNSON, Suzanne M. Scientific Programmer November 26, 1944
PLACE OF GIRTH (City, Stats, Country) PRESENT NATIONALITY [/f non-U.S. citizen, SEX
indicats kind of visa and expiration date)

Pleasantville, New York, U.S.A. U.S. citizen

> 3 CJ Mate Ry Famata

EDUCATION ({Segin with baccatauraate training and include postdoctoral}
. ne YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFEARED FIELO

University of Arizona, Tucson B.S. 1966 Chemistry

 

 

 

 

HONORS

 

MAJOR RESEARCH INTEREST
Computer applications
in medicine and chemistry

ROLE tN PROPOSED PROJECT

Applications Programmer

 

 

“RESEARCH SUPPOAT (See instructions)

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list trvnicrg and experiences relevant to area of project List alt
or most roprssentative publications, Oo not axcoed 3 pages for sach individual.)

1974 - present Scientific Programmer, SUMEX Computer Project,
Department of Genetics, Stanford University

1973 -— 1974 Scientific Programmer, Center for Radar Astronomy,
Stanford Electronics Laboratories, Stanford University
1971 - 1973 Research Assistant (crystallographic studies/computer data reduction),
Department of Chemistry, University of Iowa, Lowa City
1970 - 1971 Engineer, Geochemistry Section, Lockheed Electronics, Houston, Texas
1966 - 1969 Research Assistant (x-ray crystallographer) ,

Department of Chemistry, University of Tllinois, Urbana

PUBLICATIONS (See continuation page.)

 

NiH 393 (FORWEALY PHS 99a)
Rey. 1/73

ll

aU. S. GOVERNMENT PRINTING OFF7IC2: 1974 594-259/2004
Privileged Communication JoShua LEDERBERG

BIOGRAPHICAL SKETCH - JOHNSON, Suzanne M.

PUBLICATIONS

10.

11.

12.

13.

Th.

Johnson, S.M., Newton, M.G., Paul, I.C., Beer, R.J.S. and Cartwright,
D.: The Molecular Structure of an Unsynn netrical §a-Thiathiophthen.
Chem. Comaun., 1170, 1967.

Johnson, S.M., MeKecknie, J.S., Lin, B. T-S. and Paul, I.C.: Crystal
Structure of Bullvalene at 259. J. Am. Chem. Soc. 8937123, 1967.

Jonnson, S.M., Paul, I.C., Rinehart, K.L., Jr. and Srinivasan, R.:
The Molecular Configuration of Caldariomyein. J. Am. Chem. Soc.
90:135, 1968.

Paul, I.C., Johnson, S.s., Paquette, L.A., Barrett, J.H. and Haluska,
R.J.: The itlolecular Geometry of Derivatives of iH-Azepine in the Free
and Complexed State. J. Am. Chem. Soc. 90:5023, 1968.

Jonnson, S.M. and Paul, I.C.: Crystal and Molecular Structure of [16]
Annulene. J. Am. Chem. Soc. 90:5555, 1958.

Jonnson, S.M., Newton, M.G. and Paul, I.C.: Crystal and Molecular
Structure of an Unsymmetrical 6a-Thiatniophthen: Single- erystal X-ray

Analysis of 3~Benzoyl-5-p-bromo-pnenyl-2~methyl-thio-6a- thiathiopnthen.
J. Chem. Soe. (8), 985, 1969.

Paul, I.C., Johnson, S.M., Barrett, J.H. and Paquette, L.A.: The
Thermal (6 + 4)W Co-cycloaddition of N-alkoxycarbonylazepins: Crystal
Structure Analysis of a Derived Monomethiodide. Chen. Commun., 6, 1959.

Coates, R.M., Parney, R.F., Johnson, S.M. and Paul, I.C.: The Crystal
Structure of Khusimol p-Bromobenzoate. Chem. Commun., 999, 1959.

Johnson, S.il. and Paul, I.C.: The Crystal and Molecular Structure of
the Perhydromethiodide of an Unsyzsetrical N-~alkoxycarbonylazepine
Dimer. J. Chem. Soc. (B), 1244, 1969.

Johnson, S.. and Paul, I.C.: Crystal and Molecular Structure of
1- Acetonyl- 1-thionia-5-thia-cyclooetane Perchlorate.
Tet. Letters, 177, 1969.

Leonard, N.J., Golankiewiez, K., MoCredie, R.S., Johnson, S.M. and
Paul, 1.C.: Synthetic Spectroscopic } iodels Related to Coenzymes and
Base Pairs. III. A 1,1 t trimethyl ene-Linked Toaymine Photodiner of
ecis-syn Structure. J. Am. Chem. Soc. 91:5855, 1969.

Sabacky, M.J., Jonnson, S.M., Martin, J.c. a Paul, I.C.: Steric
Effects in ortho-Substituted Triarylmethan J. An. Chem. Soc,
91:7542, 1969.

Jonanson, S.M., Paul, I.C. and Xing, &.S.D.: [16] Annulene: The Crystal
and Molecular Structure. J. Chem. Soc. (5), 643, 1970.

Johnson, S.tl., Herrin, J., Liu, S.J. and Paul, I.C.: Crystal Structure
of a Barium Complex of Antibiotic X-537A, Ba (C34 H5 3,03 )9 Hj 0.
Chem. Commun. 72, 1970. 12
Privileged Communication Joshua LEDERBERG

BIOGRAPHICAL SKETCH - JOHNSON, Suzanne M.

Publications (continued):

15.

17.

18.

19.

Johnson, S.M., Herrin, J., Liu, S.J. and Paul, I.C.: The Crystal and
Molecular Structure of the Barium Salt of an Antibiotic Containing a
High Proportion of Oxygen. J. Am. Chem. Soc. 92:4428, 1970.

Gibson, E.K. and Johnson, S.M.: Thermal Analysis-Inorganic Gas Release
Studies of Lunar Samples. Proc. Second Lunar Science Conference
2:1351, 1971.

Gibson, E.K. and Johnson, S.M.: Thermogravimetric-Quadrupole
Mass-Spectrometric Analysis of Geochemical Samples.
Thermochimica Acta 4:49, 1972.

Carhart, R.E., Johnson, S.M., Smith, D.B., Buchanan, B.G.,
Dromey, R.G. and Lederberg, J.L.: Networking and a Collaborative
Researcn Community: A Case Study Using the DENDRAL Progran.

In Computer Networking and Chemistry (Ed. Peter Lykos),

American Chemical Society Symposium Series, No. 19, 1975.

Levinthal, E.C., Carhart, R.E., Johnson, S.M. and Lederberg, d.:
When Computers Talk to Computers. Industrial Research, November, 1975.

13
_ SECTION Ul — PRIVILEGED COMMUNICATION

BIOGRAPHICAL SKETCH

{Give tha following information for all professional personnal list2d on paga 3, beginning vath tha Principal Investigator.
Use continuation pogas and follow tha mame zeneratl format for each person}

 

 

 

 

 

 

 

NAME TITLE BIRTHOATE f{Ma, Oay, Yr.)
KAHLER, Richard Q. Scientific Programmer — November 4, 1952
PLACE OF BIRTH (City, Stats, Country) PRESENT MATIONALITY (/f non-U.S. citizan, SEX —
indicate kind of visa and expiration cata}
Los Angeles, California, U.S.A. U.S. citizen FO mats [cl Female
- : EDUCATION (3 9in with baccalauraats training and includs postdoctoral)
, YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREES CONFERRED FIELD
Stanford University (1969-72) None -- Electrical Engineering,

 

Computer Science

 

 

 

HONORS

 

MAJOR RESEAACH INTEREST Subsystem software

development, human engineering of user

programs, user/project communications
RESEARCH SUPPOAT (Soe jnstructions)

 

ROLE IN PROPOSED PROJECT

User Consultant

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Sorcing with prasent position, fst trining and experiance ralavant to ares of project. List all
or mest reorssentotive publications, Do not excesd 3 pages for ech individual.)

1975 - present Scientific Programmer, SUMEX Computer Project,
Department of Genetics, Stanford University

1975 Computer Programmer, Institute for Mathematical Studies
in the Social Sciences (IMSSS), Stanford University

PUBLICATIONS (none)

 

NIH 39a (FORMERLY PHS 9398
Rav. 1/73 398)

15

aU. S. GOVERNMENT PRINTING OF PICZ : 1974 saa0259/2006
SECTION U1 — PRIVILEGED COMMUNICATION

BIOGRAPHICAL SKETCH

{Give the following information for ail professional personnal tisted on page 3, beginning vd th the Principal lnysstigator.
Use continuation pagas and follow the sams ganersi format for each person.)

 

NAME
LEDERBERG, Joshua

TITLE

Professor and Chairman
Department of Genetics

BIRTHDATE (Ma, Day, Yr.}
May 23, 1925

 

PLACE OF BIATH (City, State, Country)

Montclaire, New Jersey, U.S.A.

 

PRESENT NATIONALITY (7f non-US eftizen, SEX

indicate kind of visa and aupiration dats}

 

U.S. citizen (XJ Mata (] Femala

 

EDUCATION (Sayin with baccalaureate training and faclud? postdoc tora)

 

 

- YeAR SCIENTIFIC
INSTITUTIGN AND LOCATION DEGREE CONFERRED FIELD
Columbia College, New York B.A. 1944
College of Physicians and Surgeons,
Columbia Univ., New York (1944-46)
Yale University Ph.D. 1947 Microbiology

 

 

 

 

HONORS

1957 - National Academy of Sciences
1958 ~ Nobel Prize in Medicine

 

MAJOR RESEARCH INTEREST
Molecular Genetics,
Artificial Intelligence

 

AOLE IN PROPOSED PROJECT

Principal Investigator

 

RESEARCH SUPPORT (See instructions)

(See continuation page.)

 

RESEARCH AND/OR PAOFESSIONAL EXPERIENCE (Startirg with prasent position, Uist training and axpariance raisvant to arza of project, List ail
or mest representative publications, Dea not exceed 3 pages for asch individual.)

1959 — present Professor and Chairman, Department of Genetics
Stanford University School of Medicine

1957 - 1959 Chairman, Department of Medical Genetics
University of Wisconson

1947 - 1957 Professor of Genetics
University of Wisconsin

SELECTED PUBLICATIONS (See continuation page.)

 

HiH 398 (FORMERLY PHS 393)
Rev. 1/73

17
Privileged Communication Joshua LEDERBERG
BIOGRAPHICAL SKETCH ~ LEDERBERG, Joshua

RESEARCH SUPPORT

Funding
Current Project % of Grant
Grant Ho. Title of Project Year Period Effort Agency
PERSONAL RESEARCH COMMITMENTS:
CA16896 Genetics of Bacteria $ 80,000 $ 464,669 15 NIH
(5/77-4/78 (5/77-4/82)
pending)
NAS1-9692 Viking Mission $ 20,000 $ 82,572 10 NASA
participation (5/77-9/78)  (4/70-9/78)

{inel. Indirect Costs)

PRINCIPAL INVESTIGATOR EX OFFICIO:

GMQ0295 Genetics Training $111,000 $ 536,363 20 NTH
Grant (graduate (7/77-6/78) 9 (7/7%-5/79)
research training)

GM20832 Genetics Research $2656 ,587 $1,292,113 10 NIB
Project (5/77-4/78) = (5/74-4/79)

NGR~05-0290-004 Cytochemical Studies $ 137,500 3 NASA
of Planetary (9/76-12/77)
Microorzanisns (inel. Indirect Costs)

SELECTED PUBLICATIONS

1. Lederberg, J.: Topology of Molecules. In The Mathematical Sciences
(Ed. Committee on Support of Research in the Mathematical Sciences
(COSRIMS) with George A.W. Boehm), MIT Press, ov. 37-51, 1959.

2. Lederberg, J., Sutherland, G.L., Buchanan, 8B.G., Feigenbaum, F.A.,
Robertson, A.V., Duffield, A.M. and Djerassi, C.: Applications of
artificial intelligence for chemical inference. I. The number of
possible organic compounds. Acyclic structures containing C, H, 0,
and N. J. Am. Chem. Soc. 91:2973-76, May 21, 1949.

3. Buchs, A., Delfino, A.B., Duffield, A.M., Djerassi, C., Buchanan,
B.a., Feigenbaum, E.A. and Lederbers, J.: Applications of artificial
intelligence for chemical inference. VI. Aporoach to a general
method of interpreting low resolution mass spectra with a computer.
Helvetia Chinica Acta 53:1394-1417, 1970.

4. Lederberg, J.: Use of Computer to Identify Unknown Compounds: The
Automation of Scientific Inference. In Biochemical Applications of
Mass Spectrometry (Ed. G.R. Waller), John Wiley and Sons, New York,
P. 193-207, 1972.

18
Privileged Communication Joshua LEDERBERG

BIOGRAPHICAL SKETCH ~ LEDERBERG, Joshua
Selected Publications (continued):

5.

6.

10.

14.

12.

13.

4.

17.

Lederberg, J.: The freedoms and the control of science — notes from
the ivory tower. Southern California Law Review 45:596~614, 1972.

Lederberg, J.: The control of chemical and biological weapons.
Stanford J. International Studies 7:22-44, 1972.

Lederberz, J.: The genetics of human nature.
Social Res. 40:375-406, 1973.

Lederberg, J.: A System-analytic Viewpoint. In How Safe is Safe? -
Tae Design of Policy on Drugs and Food Additives, National Academy
of Sciences, Washington, D.C., p. 66-94, 1974.

Masinter, L., Sridharan, N., Lederberg, J. and Smith, D.H.:
Applications of artificial intelligence for chemical inference.
XII. Exhaustive generation of cyclic and acyclic isomers.

J. Am. Chem. Soc. 96:7702-7714, 1974.

Harris-Warrick, R.M., Elkana, Y¥., Ehrlich, S.D. and Lederberg, J.:
Electrophoretic separation of B. subtilis genes (EcoR;/agarose gel
electrophoresis). Proc. Nat. Acad. Sci. U.S.A. 72:2207-2211, 1975.

Carhart, R.E., Johnson, S.M., Smith, D.H., Buchanan, B.G., Dromey,
k.G. and Lederberg, J.: Networking and a Collaborative Research
Community: A Case Study using the. DENDRAL Programs. In Computer
Networking and Chemistry (Ed. Peter Lykos), ACS Symposium Series,
No. 19, p. 192-217, 1975.

Buchanan, B.G., Smith, D.H., White, W.C., Gritter, R., Feigenbaum,
E.A., Lederberg, J. and Djerassi, C.: Applications of artificial
intelligence for cheaical inference. XXII. Automatic rule formation
in mass spectrometry by means of the meta-DENDRAL program.

J. Am. Chem. Soe. 98:6168-63878, 1975.

Sagan, C. and Lederberg, J.: The prospects for life on Mars:
A pre-Viking assessment. Icarus 28:291-300, 1976.

Ehrlich, S.D., Bursztyn-Pettegrew, H., Stroynowski, I. and
Lederberg, J.: Expression of the thymidylate synthetase gene of
the B. subtilis bacteriophage phni-3-T in E. coli.

Proc. Nat. Acad. Sei. 73:4145-4199, 1976.

Klein, H.P., Lederberg, J., Rich, A., Oyama, V.I. amd Levin, G.V.:
The Viking Mission search for life on Mars. Nature 262:2H-27, 1975.

Klein, H.P., Horowitz, N.H., Levin, G.V., Oyama, ¥.1I., Lederberg, J.,
Rich, A., Hubbard, J.S., Hobby, G.L., Straat, P.A., Berdahl, B.J.,
Carle, G.C., Brown, F.S. and Johnson, R.D.: The Viking biological
investigation: Preliminary results. Science 194:99-105, 1975.

Chi, N-Y. W., Ehrlich, $.D. and Lederberg, J.: Functional expression
of two Bacillus subtilis chromosomal genes in Escnerichia coli.
J. Bact., 1977. (In press)

19
SECTION Hl — PRIVILEGED COMMUNICATION
BIOGRAPHICAL SKETCH

{Givg the folowing information for all professional personnal listed on page 3, beginnirg with tha Principat Inyastigator.
Us? continuation pages ard follow the same ganeral format for each person)

 

NAME TITLE , BIRTHDATE (Min, Day, Yr)
. Adjunct Professor of Genetics
LEVINTHAL, E11 . . i
; fott © Dir., Instrumentation Res. Lab. April 13, 1922

PLACE OF BIRTH iCity, State, Country} PRESENT NATIONALITY [ff n0n-U.S. citizen, SEX
indicate kind of visa and expiration dats)

 

 

 

 

 

 

Brooklyn, New York, U.S.A. U.S. citizen {I Mate Cl Femata
EDUCATION {S2gin with baccalaureate training and includ postdoctoral)
< YEAR SCIENTIFIC
INSTITUTION AND LOCATION DEGREE CONFERRED FIELD
Columbia College, New York: B.A. 1942 Physics
Massachusetts Institute of Technology M.S. 1943 Physics and Math
Stanford University Ph.D. 1949 Physics and Math

 

 

 

 

HONORS
Public Service Medal, awarded by NASA, April, 1977, for exceptional contributions
to the success of the Viking project

 

MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT

Medical instrumentation research AIM Liaison

 

 

RESEARCH SUPPORT {See instructions)

(See continuation page.)

 

RESEARCH AND/OA PROFESSIONAL EXPERIENCE (Starting with orssant position, list tainicg and aaperiance ralavant to arza of project: List aif
Of Most representative publications, Do not axceed 3 pages for each individual.)
1974 - present Adjunct Professor, Department of Genetics, Stanford University;
Director, Instrumentation Research Laboratory,
Department of Genetics, Stanford University

1970 - 1973 Associate Dean for Research Affairs,
Stanford University School of Medicine

1961 - 1974 Senior Scientist/Director, Instrumentation Research Laboratories,
Department of Genetics, Stanford University

1953 - 1961 President, Levinthal Electronic Products

1952 -— 1953 Chief Engineer, Century Electronics

1950 - 1952 Research Director/Member of Board of Directors, Varian Associates ©

1949 — 1950 Research Physicist, Varian Associates

1946 - 1948 Research Associate, Nuclear Physics, Stanford University

1943 - 1946 Project Engineer, Sperry Gyroscope Company, New York

1943 Teaching Fellow in Physics, Massachusetts Institute of Technology

PUBLICATIONS (See continuation page.)

 

" WEH 398 (FORNEALY PHS 393) 21
Rev. 1/73

aU, S, COVE2NMENT PRINTING OF FIC2 11974 sae%259/2004
Privileg
BIOGRAPH

RESEARCH

Grant

NAS1-968

NGR-05-0

GiH20832

RR-00612

ed Communication Joshua LEDERBERG

ICAL SKETCH - LEVINTHAL, Elliott C.
SUPPORT
Funding
Current Project. 4% of Grant
No. Title of Project Year Period Effort Agency
2 Viking Mission $ 85,000 $ 175,552 50 NASA
participation (11/76-9/77) (11/75~-9/78)
20-004 Cytochemical Studies $ 137,500 11 NASA
of Planetary (9/76-12/77)
Microorganisms
Genetics Research $ 266,587 $1,292,113 8 NIH
Project (5/77-4/78) — (5/74-4/79)
Resource Related $ 218,580 & 698,399 6 NIH

Research-Computers . (5/77-4/78) (5/77-4/80)
and Chemistry
( DENDRAL)

SELECTED PUBLICATIONS AND PAPERS

1.

4,

Levinthal, &.C.: Detection of Extraterrestrial Life. Professional
and Technical Group of Instrumentation and Measurements of IEEE,
April, 1963.

Levinthal, £.C.: The Detection of Life within our Planetary System.
Presented at WESCON, August, 1963.

Levinthal, E.C.: The Biological Exploration of Mars. Presented at the
Space Technology Laboratory’s Invited Lecture Series, November 6, 1963.

Levinthal, E.C.: The Biological Exploration of Mars. Presented at
woffet Field, Fullerton, Los Angeles and San Diezo, as part of the
University of California Extension Series Lectures -~ Horizons in
Space Biosciences: Exobiology, April 27-30, 1964.

Levintnal, E.C., Lederberg, J. and Hundley, L.: Multivator - 4
Biochemical Laboratory for Martian Experiments. Life Seiences and
Space Research II, COSPAR (Committee on Space Research), 1964.

Halpern, B., Westley, J.W., Levinthal, E.C. and Lederberg, J.:

Tne Pasteur Probe: An Assay for Molecular Asymmetry. Life Sciences
and Space Research, COSPAR (Committee on Space Research), 1956.
Levinthal, &.C.: Space Yehicles for Planetary Missions. In Biology

and the Exploration of Mars, Nat. Acad. Sei., National Research Council.

22
Privileged Communication Joshua LEDERBERG

BIOGRAPHICAL SKETCH - LEVINTHAL, Elliott C.

selected Publications and Papers (continued):

8.

9.

10.

11.

T2.

13.

14.

15.

16.

V7.

‘Masursky, H., Batson, R., Borgeson, W., Carr, M., MeCauley, J

Levinthal, E.C.: Prospects for Manned Mars Missions. In Biology and
the Exploration of Mars, Nat. Acad. Sci., National Research Council.

Reynolds, O., Levinthal, E. and Soffen, G.: The Role of the Scientist
in Automated Laboratory Systems. AIAA Paper No. 67-632, 1967.

Levinthal, E.C., Lederberg, J. and Sagan, C.: Relationship of Planetary
Quarantine to Biological Search Strategy. Presented at COSPAR Meeting
(Committee on Space Research), London, 1967.

Sagan, C., Levinthal, E.C. and Lederberg, J.: Contamination of Mars.
Seience 159:1191-1196, 1968.

Levinthal, E.C.: The Role of Molecular Asymmetry in Planetary
Biological Exploration. Presented at Gordon Pesearch Conferences,
Nuclear Chemistry Section, 1968.

Kriss, J.P., Bonner, W.A. and Levinthal, E.C.: Variable Time-Lapse
Videoscintiscope: A Modification of the Scintillation Camera Designed
for Rapid Flow Studies. J. Nuclear Med. 10:249, 1959.

Reynolds, W.E., Bacon, V.A., Bridges, J.C., Coburn, T.C., Halpern, B.,
Lederberg, J., Levinthal, &.C. and Steed, E.: A Computer Operated
Mass Spectrometer System. Anal. Chem. 42:1122, 1970.

“s

Milton, D., Wildey, R. and Wilhelms, D., Murray, B., Horowitz, N.,
Leighton, R. and Sharp, R., Thompson, W., Briggs, G., Chandeysson, P.
and Shipley, E., Sagan, C. and Pollack, J., Lederoerg, J., Levinthal, E.,
Hartmann, W, McCord, T., Smith, 8., Davies, M., de VYaucouleurs, G.,
Leovy, C.: Television Experiment for Mariner Mars 1971.

Iearus 12:10-45, 1970.

Masursky, H., Batson, R.M., McCauley, J.F., Soderblom, L.A.,

Wildey, R.L., Carr, M.H., Milton, D.J., Wilhelms, D.E., Smith, B. A.,
Kirby, T.B., Robinson, J.C., Leovy, C.B., Briggs, G.A., Duxbury, T.C.,
Acton, C.H., Jr., Murray, B.C., Cutts, J.A4., Sharp, R.P., Smith, Susan,
Leignton, R.B., Sagan, C., Veverka, J., Noland, M., Lederberg, J.,
Levinthal, E., Pollack, J.B., Moore, J.T., dr., Hartmann, W.X.,
Shipley, E.N., de Vaucouleurs, G., Davies, M.&.: Mariner 9 Television
Reconnaissance of Mars and Its Satellites: preliminary Results.

Science 175(4919):294, 1972.

C., Morris, E.C.,

Muteh, T.A., Binder, A.B., Huck, F.O., Levinthal, &.
earus 16:92, 1972.

Sagan, Carl and Young, A.T.: Imaging Exveriment. I

Sagan, Carl, Veverka, Joseph, Fox, Paul, Dubisen, Russel, Lederberg,
Joshua, Levintnal, Elliott, Quam, Lyna, Tucker, Robert, Pollack,

James B. and Smith, Bradford A.: Variable Features on Mars: Preliminary
Mariner 9 Television Results. Icarus 17:346, 1972.

23
Privileged Communication Joshua LEDERBERG

BIOGRAPHICAL SKETCH - LEVINTHAL, Elliott C.

Selected Publications and Papers (continued):

19.

20.

21.

‘22.

23.

24.

25.

Levinthal, E.C., Green, W.B., Cuts, J.A., Janelka, E.D., Johnsen, R.A.,
Sander, M.J., Seidman, J.B., Young, A.T. and Soderblom, L. A.:
Mariner 9 - Image Processing and Products. Icarus 18:1088, 1973.

Sagan, C., Veverka, J., Fox, P., Dubisch, R., French, R., Gierasch, P.,
Quam, L., Lederberg, J., Levinthal, E., Tucker, R., Eross, B. and
Pollack, J.B.: Variable Features on Mars, 2, Mariner 9 Global Results.

J. Geophysical Research 78, No. 20, p. 4163-4196, 1973.

Lederberg, J., Feigenbaum, E., Levinthal, E. and Rindfleisch, T.:
SUMEX - A Resource for Application of Artificial Intelligence in
Medicine. Proc. Ann. Conference, Association for Computing Machinery,
November, 1974.

Levinthal, E.C., Carhart, R.E., Johnson, S.M. and Lederberg, J.: When
Computers Talk to Bach Other. Industrial Research 17(12):35-42, 1975.

Mutch, T.A., Binder, A.B., Huck, F.O., Levinthal, E.C., Liebes, S.,
Morris, E.C., Patterson, W.R., Pollack, J.B., Sagan, C. and

Taylor, G.R.: The Surface of Mars: The View from the Viking I Lander.
Seience 193(4255):791-801, 1976.

Mutch, T.A., Arvidson, R.E., Binder, A.B., Huck, F.O., Levinthal, E.c.,
Liebes, S., Jr., Norris, E.C., Nummedal, D., Pollack, J.B. and Sagan, C.
Fine Particles on Mars: Observations with the Viking I Lander Cameras.
Seience 194(4260):87-91, 1976.

Levinthal, E.C. and Huck, F.O.: Multispectral and Stereo Imaging on

Mars. In Astronautical Research 1976 —- A New Era cf Space Transportation,
Pergamon Press, 1976. Proc. of the XXVII International Astronautical
Congress, Anaheim, California, 1976.

Muteh, T.A., Arvidson, R.E., Aurin, P., Binder, A.B., Huck, F.O.,
Levinthal, E.C., Liebes, S., Jr., Morris, E.C., Pollack, J.B., Sagan,
C. and Saunders, R.: The Surface of Mars: The View from Lander 2,
Seience 194(4271):1277-1283, 1976.

24
SECTION I — PRIVELEGEO COMMUNICATION _
BIOGRAPHICAL SKETCH

{Give tha following information for all professional parsonnel listed on page 3, beginning with the Princioal Investigetor.
Use continuation pages and follow tha same ganar format for each person}

 

 

 

 

 

 

 

 

 

 

 

 

NAME TITLE BIATHDATE (a, Day, Yr}
NII, H. Penny Scientific Programmer - October 6, 1939
PLACE OF BIRTH {City, Stats, Country) PRESENT NATIONALITY (ff non-US, citizen, SEX
indicate kind af visa and expiration data)
Tokyo, Japan U.S. citizen Climate 3) Farmata-
EOUCATION (B2gin with baccalaursate trainirg and includs postdoctoral)
. , eras YEAR SCIENTIFIC

INSTITUTION AND LOCATION DEGREE CONFEARED FIELD

Tufts University, Jackson College, . B.S. 1962 Mathematics
Medford, Massachusetts

Stanford University M.A. 1973 Computer Science
HONOAS
BIAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT
Knowledge-based computer systems design Scientific Programmer —

,

AI tool generalization

 

 

RESEARCH SUPPORT (Ses instructions)

(See continuation page.)

 

RESEARCH AND/OR PROFESSIONAL EXPERIENCE {Srartirg wath prasent position, list triining and experiance ratevant to arsa of project. List pl}
or mest rprssentativa publications, Do not axceed 3 pages for each individual.)

1976 - present Scientific Programmer, Heuristic Programming Project,
Department of Computer Science, Stanford University

1973 - 1975 Associate Investigator for Computer Science, HASP Project,
Systems Control, Inc., Palo Alto, California
1967 ~ 1968 Systems Engineering Advisor, International Business Machines
World Trade Asia Corporation, Tokyo, Japan
1962 - 1967 Research Staff Programmer, International Business Machines Corporation,

Thonas J. Watson Research Center,
1965-67 Project Leader, Electronic Coding Pad (ECP) System
1965-66 Assistant Manager, Man-Computer Interaction Group
1963-64 Programmer, World's Fair Lexical Processing System
1962-63 Programmer, applications ranging from text processing
to linear programming problems

RECENT PUBLICATIONS (See continuation page.)

 

WIH 338 (FORWEALY PHS 998) 2
Rov. 1/73
&U, 3, GOVERNMENT PRINTING OFFICE: 1974 se4-25g/0008