SUMEX STANFORD UNIVERSITY MEDICAL EXPERIMENTAL COMPUTER RESOURCE COMPETING RENEWAL APPLICATION RR - 00785 BOOK II COLLABORATIVE PROJECTS AND APPEND IXES Submitted to BIOTECHNOLOGY RESOURCES PROGRAM NATIONAL INSTITUTES OF HEALTH June 1, 1977 DEPARTMENT OF GENETICS STANFORD UNIVERSITY SCHOOL OF MEDICINE Joshua Lederberg, Principal Investigator wer AFT rrr Fora » Approved | SECTION 1 . O.N.B. 68-R0249 DEPARTMENT OF LEAVE BLANK HEALTH, EDUCATION, AND WELFARE TYPE !PROGRAM NUMBER PUBLIC HEALTH SERVICE REVIEW GROUP. |FORMERLY GRANT APPLICATION COUNCIL (Month, Year} DATE RECEIVED TO BE COMPLETED BY PRINCIPAL INVESTIGATOR (items 1 through 7 and 158A} 1, TITLE OF PROPOSAL (Do not exceed 53 typewriter spaces) S U Medical EXperimental Computer Resource (SUMEX) __2. PRINCIPAL INVESTIGATOA 2A. NAME (Last, First, Initial) LEDERBERG, Joshua 2B. TITLE OF POSITION Professor and Chairman 13. OATES OF ENTIRE PROPOSED PROJECT PERIOD (This application, FROM THROUGH 8/1/78 7/31/83 4, TOTAL DIRECT COSTS RE- |5. OFRECT COSTS REQUESTED QUESTED FOR PERIOD IN FOR FIAST 12-MONTH PERIOC ITEM3 $ 5,155,655 $ 744,300 2G. MAILING ADDRESS (atreer City, State, Zip Code) Department of Genetics Stanford University Medical Center Stanford, California 94305 3. DEGREE SOC‘ Ph.D. 2F.TELE- [Ares LEPHONE N bara | 415 TON 497-5801 6, PEAFORMANCE SITE(S) (See Instructions) ‘Stanford University 2G. DEPARTMENT, SERVICE, LABORATORY OR EQUIVALENT — (See Instructions) Department of Genetics ZH. MAJOR SUBDIVISION (See Instructions} School of Medicine 7. Research Involving Human Subjects (See Trstructions} A. NO 8.([) VES Approved: C.C) YES — Pending Review Oates &. inventions (Henewal Appiicents Only - Ses Instructions) A.CKINO 8.((] YES — Not previously reported C.CLIVES — Previously reportea TO BE COMPLETED BY RESPONSIBLE ADMINISTRATIVE AUTHORITY (items 8 through 13 and 158) 9. APPLICANT ORGANIZATIONIS) (See fnstructions) Stanford University Stanford, California 94305 IRS No. 94-1156365 Congressional District No. 12 Tl. TYPE OF ORGANIZATION (Check applicable item] Coreoera. Clstate CIULOcCAL ROTHER (Specify) Private Non-Profit University TZ. NAME, TITLE, AODRESS, AND TELEPHONE NUMBER OF OFFICIAL IN BUSINESS OFFICE WHO SHOULD ALSO BE NOTIFIEO !F AN AWARD IS MADE K. D. Creighton Associate Vice President - Controller Stanford University - Stanford, California 94305 10. NAME, TITLE, AND TELEPHONE NUMBER OF OFFICIALIS) SIGNING FOR APPLICANT ORGANIZATION(S) D'Ann B. Downey Sponsored Projects. Officer _Sponsored Projects Office Telzphone Numoer {+} (415) 497-2883 eet Number (415) 497—2251_ MPONEN RECEIVE CR FOR INSTITUTIONAL GRANT PURPOSES (See Instructions) O01 School of Medicine 14. ENTITY NUMBER (Formerly PHS Account Number) IRS No. 94-1156365 15, CERTIFICATION AND ACCEPTANCE. We, the undersigned, certify that the statements herein ore true end complete to the best of our knowledge and accept, as to any grant swarded, the obligation ta comply with Public Health Service terms and conditions in effect at the time of the sward, SIGNATURES Be STON ATUAEOR BESSON NAMED IN ITEM 2A DATE (Signatures required on original copy only. ATUREIS OF one) £0 iN ITEM 2.0 DATE iso ink, “Per® signatures — 2; not occeptable) ae S, lz f77 wv win 398 (FORMERLY PHS 398) Rev. 1/73 Sea The undersigned agrees to accept responsibility for the scientific and technical conduct of the project and for the provision of required progress reports if a grant is awarded as the result of this application. 5/24/77 OQ thy, Date e// Principal Investigator / Table of Contents BOOK II Section »5. BIOGRAPHICAL SKETCHES . ee . 2 8 ee 6. COLLABORATIVE PROJECT PROGRESS AND OBJECTIVES . 6 6.1 STANFORD PROJECTS . . . . ul. - 2 e 6.1.1 DENDRAL PROJECT . . . wwe 6.1.2 HYDROID PROJECT . 2... eh lk kk 6.1.3 MOLGEN PROJECT . . . 2. 2 2 2 ew 6.1.4 MYCIN PROJECT 8 ee 6.1.5 PROTEIN STRUCTURE PROJECT 8 8 8 6.2 NATIONAL AIM PROJECTS . . . . . 6.2.1 ACQUISITION OF COGNITIVE PROCEDURES (ACT) 6.2.2 CHEMICAL SYNTHESIS PROJECT (SECS) . . . 6.2.3 HIGHER MENTAL FUNCTIONS PROJECT . 8 6.2.4 INTERNIST PROJECT . . 2... 6.2.5 MEDICAL INFORMATION SYSTEMS LABORATORY an . thw . oO RUTGERS COMPUTERS IN BIOMEDICINE . . . 6.3 PILOT STANFORD PROJECTS 6.3.1 GENETICS APPLICATIONS PROJECT . . . . 6.3.2 BAYLOR-METHODIST CEREBROVASCULAR PROJECT 6.3.3 COMPUTER AWALYSIS OF CORONARY ARTERIOGRAMS 6.3.4 QUANTUM CHEMICAL INVESTIGATIONS - Privileged Communication i Page * 6» « 1 - . 41 - AN - .« 42 - « 76 - .« 81 - . 84 tos 108 » « 112 113 - 118 » « 128 - + 132 - «+ 138 - » 4h . . 158 + 159 - + 161 © + 165 + «+ 169 - Lederberg TABLE OF CONTENTS BOOK II (continued) 6.4 PILOT AIM PROJECTS . . . 2... ee 6.4.1 COMMUNICATION ENHANCEMENT PROJECT . 6.4.2 AI IN PSYCHOPHARMACOLOGY . . . . 6.4.3 ORGAN CULTURE PROJECT. . .. . 6.4.4 NEUROPROSTHESES PROJECT . . . 6.4.5 MATHEMATICAL MODELING OF PHYSIOLOGICAL 6.4.6 PUFF/VM PROJECT . . 2. 2. we Appendix I OVERVIEW OF ARTIFICIAL INTELLIGENCE RESEARCH Appendix II AI HANDBOOK OUTLINE 8 8 ee el Appendix III SUMMARY OF MAINSAIL LANGUAGE FEATURES . . Appendix IV MICROPROGRAMMED MAINSAIL PLANS . . .. . Appendix V AIM MANAGEMENT COMMITTEE MEMBERSHIP Appendix VI USER INFORMATION - GENERAL BROCHURE Appendix VII GUIDELINES FOR PROSPECTIVE USERS Privileged Communication ii . SYSTEMS . * os 6 «6 171 - - 172 - « 179 . - « 189 7 «© « 194 . 194 » «6 «+ 197 » « 202 © 6+ 2 225 * 6 « 231 © 6 6 235 - 6 «) 239 - 6 2 243 ~ . 245 J. Lederberg