dUN 9 4 °1977

BIOMEDICAL KNOWLEDGE ENGINEERING
AND
INFECTIOUS DISEASES

Submitted to the
Nationa! Institutes of Health

May, 1977

Stanford University Medical School
Computer Science Department

Stanford University
— S. N. Cone

Table of Contents
SECTION II

Page

Detailed Budget é * . e . * e * . ‘ . e . . « « . 3
Budget Estimates and Justification . . . . .. 6.6.6.
Biographical Sketches. . . « . « « «© «© «© « « « 4AH=4N

Research Plan . 1 «© «6 «© » © «© «© © «© «© 2 ee 5
1. Objectives es © © ee ew lk le lk 5
2. Background and Rationale . . .. . +, 4... .,. «6
2.1 The Knowledge Engineering Problem... . , 6
2.2 The Medical Problem oe ee le 7
2.3 Our Work to Date a 9
2.4 Other Approaches = ee ee we ew le
3. Previous Work Done ee ee lk
4, Specific Goals yee ee we le
| Competence oe ee eee eC

4,2 Knowledge Engineering Support Tools . . . . 18

4,3 Human Engineering and Clinical
Capabilities . +. . . 6 2. 2. © «© « w 20
44 Exportability of the System. . . . . . . 22
4.5 Performance Evaluation ee ee ele lee OY
5. Significance of the Research. . . . . « « « « 26
6. Facilities Available . . . . . . oe uw uw we 27
T. Collaborative Arrangements ee ee ele le le OB
8. Appendix A: Progress Report Submitted to BHSRE . . . 29
PRIVILEGED COMMUNICATION

9.

10.

8.1 Summary .

8.2 Detailed Report .

‘

8.3 Clinical Capabilities ,

8,4 User Oriented Features

8.5 Knowledge Acquisition .

8.6 Technical Issues

s

8.7 Evaluation Activities ,

Appendix B: Hardware Announcement

REFERENCES .

10.1 MYCIN PUBLICATIONS

10.2 OTHER REFERENCES

li

se ew ee YQ
"6 ew 6 e) 29
+ 8 8 2 vw) 30
ee 6 ww OSM

s 8 8 6 «6333
» ° » e 6 « 34

oe 6 «© «© 6) 34

ee ee we we AG

e « * . . * 45
e e 4S

. s a * . . 47