HPP-69-6

J. Lederberg, G.L. Sutherland, B.G. Buchanan, E.A. Feigenbaum,
A.V. Robertson, A.M. Duffield, and C. Djerassi,

"Applications of Artificial Intelligence for Chemical Inference
I. The Number of Possible Organic Compounds: Acyclic Structures
Containing C, H, 0 and N". Journal of the American Chemical
Society, 91 (1969).

HPP-69-7

A.M. Duffield, A.V. Robertson, C. Djerassi, B.G. Buchanan,
G.L. Sutherland, E.A. Feigenbaum, and J. Lederberg,
"Application of Artificial Intelligence for Chemical
Inference II. Interpretation of Low Resolution Mass
Spectra of Ketones". Journal of the American Chemical
Society, 91:11 (May 21, 1969).

HPP~69-8

C.W. Churchman and B.G. Buchanan,

"On Design of Inductive Systems: Some Philosophical
Problems". British Journal for the Philosophy of
Science, 20 (1969).

HPP-69-9

G. Schroll, A.M. Duffield, C. Djerassi, B.G. Buchanan,
G.L. Sutherland, E.A. Feigenbaum, and J. Lederberg,
"Application of Artificial Intelligence for Chemical
Inference III. Aliphatic Ethers Diagnosed by Their
Low Resolution Mass Spectra and NMR Data". Journal of
the American Chemical Society, 91. (1969).

HPP~70-1

A. Buchs, A.B. Delfino, C. Djerassi, A.M. Duffield,
B.G. Buchanan, E.A. Feigenbaun, J. Lederberg and

G. Schroll,

"Application of Artificial Intelligence for Chemical
Inference. IV. Saturated Amines Diagnosed by Their
Low Resolution Mass Spectra and Nuclear Magnetic
Resonance Spectra", Journal of the American Chemical
Society, 92, (1970).

HPP-70-2

AIM-123

Bruce G. Buchanan, Thomas E. Headrick,

"Some Speculation About Artificial Intelligence and

Legal Reasoning", (May 1970). Stanford Law Review Fall 1970.

HPP-70-3

Y.M. Sheikh, A. Buchs, A.B. Delfino, G. Schroll,

A.M. Duffield, C. Djerassi, B.G. Buchanan, G.L. Sutherland,
E.A. Feigenbaum and J. Lederberg,

"Applications of Artificial Intelligence for Chemical
Inference V. An Approach to the Computer Generation

of Cyclic Structures. Differentiation Between All The
Possible Isomeric Ketones of Composition C6H100",

Organic Mass Spectrometry, 4, 493, (1970).

4
HPP-70-4

A. Buchs, A.B. Delfino, A.M. Duffield, C. Djerassi,
B.G. Buchanan, E.A. Feigenbaum and J. Lederberg,
"Applications of Artificial Intelligence for Chemical
Inference VI. Approach to a General Method of
interpreting Low Resolution Mass Spectra with a
Computer", Helvetica Chimica Acta, 53, 1394 (1970).

HPP-70-5

AIM-131, CS~176, AD715128

Edward A. Feigenbaum, Bruce G. Buchanan, Joshua Lederberg,
"On Generality and Problem Solving: a Case Study Using the
DENDRAL Program", (August 1970). Also in

Machine Intelligence-6, Edinburgh Univ. Press, 1971.

HPP-71~1

A. Buchs, A.B. Delfino, C. Djerassi, A.M. Duffield,

B.G. Buchanan, E.A. Feigenbaum, J. Lederberg, G. Schroll,

and G.L. Sutherland,

"Applications of Artificial Intelligence for Chemical Inference VII.
The Application of Artificial Intelligence in the

Interpretation of Low-Resolution Mass Spectra", Advances

in Mass Spectrometry, 5, 314 (1971).

HPP-71~2

AIM~141, CS-205, AD730506

Bruce G. Buchanan, Joshua Lederberg,

“The Heuristic DENDRAL Program for Explaining Data",
In proceedings of the IFIP Congress 71, Ljubljana,
Yugoslavia (February 1971).

HPP~71-3

AIM-147, CS=-216, AD732457

Robert E. Kling,

"Reasoning by Analogy with Applications to
Heuristic Problem Solving: a Case Study",
Thesis: Ph.D. in Computer Science (August 1971).

HPP-71-4

AIM-141

B.G. Buchanan, E.A. Feigenbaum, and J. Lederberg,

"A Heuristic Programming Study of Theory Formation in
Science". In proceedings of the Second International
Joint Conference on Artificial Intelligence,

Imperial College, London (September 1971).

HPP-71-5

B.G. Buchanan, A.M. Duffield, A.V. Robertson,

"An Application of Artificial Intelligence to the Interpretation
of Mass Spectra", Mass Spectrometry Techniques and Appliances,
G.W.A. Milne, Ed., John Wiley & Sons, Inc., p- 121, (1971).
HPP-72-1

D.H. Smith, B.G. Buchanan, R.S. Engelmore, A.M. Duffield, A. Yeo,
E.A. Feigenbaum, J. Lederberg, and C. Djerassi,

“Applications of Artificial Intelligence for Chemical Inference.
VIII. An Approach to the Computer Interpretation of the High
Resolution Mass Spectra of Complex Molecules. Structure
Elucidation of Estrogenic Steroids", Journal of the American
Chemical Society, 94, 5962 (1972).

HPP-72-2
B.G. Buchanan, E.A. Feigenbaum, and N.S. Sridharan,
"Heuristic Theory Formation: Data Interpretation and

Rule Formation". In Machine Intelligence 7, Edinburgh University
Press (1972).

HPP-72-3

AIM-181, CS-325

Bruce G. Buchanan,

"Review of Hubert Dreyfus’ ‘What Computers Can’t Do’: a Critique
of Artificial Reason", (December 1972).

Computing Reviews (January, 1973).

Also in Computing Reviews, January 1973.

HPP-72-4

J. Lederberg,

"Rapid Calculation of Molecular Formulas from Mass Values".
Journal of Chemical Education, 49, 613, (1972).

HPP-72-5

Joshua Lederberg,

"Use of a Computer to Identify Unknown Compounds:

The Automation of Scientific Inference",

Biochemical Applications of Mass Spectrometry, (1972).

HPP-72-6
STAN-CS-318
H. Brown, L. Masinter, and L. Hjelmeland,

"Constructive Graph Labeling Using Double Cosets". Discrete
Mathematics, 7, 1 (1974).

HPP-73-1

D.H. Smith, B.G. Buchanan, R.S. Engelmore, H. Aldercreutz and

C. Djerassi,

"Applications of Artificial Intelligence for Chemical Inference
IX. "Analysis of Mixtures Without Prior Separation as Illustrated

for Estrogens". Journal of the American Chemical Society, 95,
6078 (1973).

HPP-73-2

D.H. Smith, B.G. Buchanan, W.C. White, E.A. Feigenbaum,

C. Djerassi and J. Lederberg,

"Applications of Artificial Intelligence for Chemical Inference
X. "INTSUM. A Data Interpretation Program as Applied to the

Collected Mass Spectra of Estrogenic Steroids". Tetrahedron, 29,
3117, (1973).

6
HPP-73-3
AIM-205, CS~370, AD764288
N.S. Sridharan, et.al,

"A Heuristic Program to Discover Syntheses for Complex Organic
Molecules", (June 1973).

HPP-73-4

STAN-CS -73-381

N.S. Sridharan,

"Computer Generation of Vertex Graphs", (July 1973).

HPP-73-5

R. Carhart and C. Djerassi,

“Applications of Artificial Intelligence for Chemical
Inference XI: The Analysis of C13 NMR Data for Structure

Elucidation of Acyclic Amines", Journal of the American Chemical
Society (Perkin II), 1753, (1973).

HPP-73-6

AIM-215, CS~387, AD769380

B.G. Buchanan and N.S. Sridharan,

"Analysis of Behavior of Chemical Molecules:

Rule Formation on Non-Homogeneous Classes of Objects".

In proceedings of the Third International Joint

Conference on Artificial Intelligence, (August 1973).

Also in Machine Intelligence-7, Edinburgh Univ. Press, 1974.

HPP~73-7

D. Michie and B.G. Buchanan,

"Current Status of the Heuristic DENDRAL Program for
Applying Artificial Intelligence to the Interpretation
of Mass Spectra", in "Computers for Spectroscopy",
[Also: University fo Edinburgh, School of Artificial

Intelligence, Experimental Programming Report No. 32
(1973).]

HPP-—73-8

AIM-217, CS-391, AD770610

N.S. Sridaran

"Search Strategies for the Task of Organic Chemical
Synthesis", (August 1973).

HPP-73-9

E.H. Shortliffe, S.G. Axline, B.G. Buchanan, T.C. Merigan,

S.N. Cohen,

"An Artificial Intelligence Program to Advise Physicians Regarding

Antimicrobial Therapy", Computers and Biomedical Research, 6:544-560
(1973).
HPP-73-10

AIM-216, CS-389, AD71299

Larry Masinter, N.S. Sridharan, J. Lederberg, D.H. Smith
"Applications of Artificial Intelligence for Chemical Inference
XII: Exhaustive Generation of Cyclic and Acyclic Isomers",
(September 1973). Also in J. Am. Chem. Soc. Vol. 96, No. 25,
December 11, pp. 7702-7714, (1974).

HPP-74-1

E.H. Shortliffe, S. G. Axline, B.G. Buchanan, S.N. Cohen,
"Design Considerations for a Program to Provide Consultations
in Clinical Therapeutics, Proceedings of San Diego Biomedical
Symposium 1974 (February 6-8 1974).

HPP~74-2

AIM-251, CS-465, ADAQ01373

Edward H. Shortliffe,

"MYCIN: A Rule-Based Computer Program for Advising Physicians
Regarding Antimicrobial Therapy Selection", Thesis: Ph.D. in
Medical Information Sciences,

Thesis: Ph.D. in Medical Information Sciences, (October 1974).

HPP-74-3
B.G. Buchanan,
"Scientific Theory Formation by Computer". In Proceedings of NATO

Advanced Study Institute on Computer Oriented Learning Processes,
Bonas, France, (1974).

HPP-74-4
E.A. Feigenbaun,
"Computer Applications: Introductory Remarrks", in "Proceedings of

Federation of American Societies for Experimental Biology", 33, 2331
(1974).

HPP-74-5
L.M. Masinter, N.S. Sridharan, R.E. Carhart and D.H. Smith,
"Applications of Artificial Intelligence for Chemical Inference XIII.

Labeling Of Objects Having Symmetryl,2", Journal of the American
Chemical Society, 96, 7714, (1974)/

HPP-74-6
D. Michie and B. G. Buchanan, "The Scientist’s Apprentice."

In Computers for Spectroscopy (ed. R.A.G. Carrington)
London: Adam Hilger, 1974.

HPP-75-1
E.H. Shortliffe, B.G. Buchanan,

"A Model of Inexact Reasoning in Medicine", Mathematical
Biosciences, 23:351-379, (1975).

HPP-75-2

E.H. Shortliffe, R. Davis, S.C. Axline, B.G. Buchanan, C.C. Green,
S.N. Cohen,

"Computer-Based Consultations in Clinical Therapeutics;

Explanation and Rule Acquisition Capabilities of the MYCIN System",
Computers and Biomedical Research, 8: 303-320, (August 1975).

8
HPP-75-3
E.H. Shortliffe, F.S. Rhame, S.G. Axline, S.N. Cohen, B.G. Buchanan, R. Davis,
A.C. Scott, R. Chavez~Pardo, and W.J. Van Melle,

"MYCIN: A Computer Program Providing Antimicrobial Therapy Recommendations".
Clinical Medicine, (August 1975).

HPP~75-4

E.H. Shortliffe,

"Judgmental Knowledge as a Basis for Computer-Assisted Clinical
Decision Making, Proceedings of the 1975 International Conference on
Cybernetics and Society, (September 1975).

HPP-75-5

E.H. Shortliffe, S. Axline, B.G. Buchanan, R. Davis, S. Cohen,

"A Computer-Based Approach to the Promotion of Rational Clinical Use of
Antimicrobials, International Symposium on Clinical Pharmacy and Clinical
Pharmacology, (September 1975), Boston, Mass. Also in

Clinical Pharmacy and Clinical Pharmacology, William A. Gouveia,

Gianni Tognoni, Eppo van der Kleijn, Editors, Elsevier/North-Holland
Publishing Company, pp. 259-274, (1976).

HPP~-75-6
AIM-266, CS-517, ADA019641
Randall Davis, Bruce Buchanan, Edward Shortliffe,

"Production Rules as a Representation of a Knowledge-Based Consultation
Program’, (October 1975).

HPP-75-7

AIM=-271, CS-524,, ADAO19702/owWC

Randall Davis, Jonathan King,

“An Overview of Production Systems", Machine Representations of
Knowledge", Dordrecht, D. Reidel Publ. Co., 1976. Proceedings of
NATO ASI Conference, (October 1975).

HPP-75~8

R.G. Dromey, B.G. Buchanan, J. Lederberg and C. Djerassi,
“Applications of Artificial Intelligence for Chemical Inference. XIV.
"A General Method for Predicting Molecular Ions in Mass Spectra"

» Journal
of Organic Chemistry, 40, 770 (1975).

HPP-75~-9

D.H. Smith,

“Applications of Artificial Intelligence for Chemical Inference. XV.
Constructive Graph Labelling Applied to Chemical Problems.
Chlorinated Hydrocarbons". Analytical Chemistry, 47, 1176 (1975).

HPP-75-10

R.E. Carhart, D.H. Smith, H. Brown and N.S. Sridharan,

"Applications of Artificial Intelligence for Chemical Inference XVI.
Computer Generation of Vertex Graphs and Ring Systems", Journal of
Chemical Information and Computer Science, 15, 124 (1975).
HPP-75-11

R.E. Carhart, D.H. Smith, H. Brown and C. Djerassi,

"Applications of Artificial Intelligence for Chemical Inference XVII.
An Approach to Computer~Assisted Elucidation of Molecular Structure",
Journal of the American Chemical Society, 97, 5755 (1975).

HPP~75-12

B.G. Buchanan,

"Applications of Artificial Intelligence to Scientific Reasoning", In
Proceedings of Second USA-Japan Computer Conference, American Federation
of Information Processing Societies Press, (August 1975).

HPP-75-13

R.E. Carhart, S.M. Johnson, D.H. Smith, B.G. Buchanan, R.G Dromey,

J. Lederberg,

"Networking and a Collaborative Research Community: A Case Study Using
the DENDRAL Program", in "Computer Networking and Chemistry", P. Lykos,
Ed., American Chemistry Society, Washington, D.C., (1975).

HPP-75-14
D.H. Smith,
"The Scope of Structural Isomerism", Artificial Intelligence for Chemical

Inference. XVIII. Journal of Chemical Information and Computer Sciences,
15, 203 (1975).

HPP-75-15
E.H. Shortliffe, R. Davis,

"Some Considerations for the Implementation of Knowledge-Based Expert
Systems", SIGART Newsletter, 55:9-12, (December 1975).

HPP-76-1
D.H. Smith, J.P. Konopelski and C. Djerassi,
“Applications of Artificial Intelligence for Chemical Inference. XIX.

Computer Generation of Ion Structures", Organic Mass Spectrometry, ll,
86, (1976).

HPP-76-2
Raymond E. Carhart and Dennis H. Smith,
"Applications of Artificial Intelligence for Chemical Inference XX.

Intelligent Use of Constraints in Computer-Assisted Structure Elucidation".
(1976).

HPP-76-3

C.J. Cheer, D.H. Smith, and C. Djerassi,

"Applications of Artificial Intelligence for Chemical Inference XXI.
Chemical Studies of Marine Interbrates - XVII. The Computer-Assisted
Identification of [+]-Palostrol in the Marine Organism Cespitularia

sp., aff. subviridis". Tetrahedron. Vol. 32, pp. 1807 to 1810, Pergamon
Press, (1976).

10
HPP~76-4

B.G. Buchanan, D.H. Smith, W.C. White, R.J. Gritter, E.A. Feigenbaun,
J. Lederberg, and Carl Djerassi,

"Application of Artificial Intelligence for Chemical Inference XXII.
Automatic Rule Formation in Mass Spectrometry by Means of the

Meta-DENDRAL Program", Journal of the American Chemical Society, 98,
6168 (1976).

HPP-76-5

T.H. Varkony, R.E. Carhart and D.H. Smith,

“Applications of Artificial Intelligence for Chemical Inference XXIII.
Computer~Assisted Structure Elucidation. Modelling Chemical Reaction
Sequences Used in Molecular Structure Problemsl,2". (1976).

HPP-76-6

D.H. Smith and R.E. Carhart

“Applications of Artificial Intelligence for Chemical Inference

XXIV. Structural Isomerism of Mono and Sesquiterpenoid Skeletons 1,2-",
Tetrahedron, Vol. 32, pp. 2513 to 2519, Pergamon Press (May 1976).

HPP--76-7

AIM-283, CS-552

Randall Davis,

"Applications of Meta Level Knowledge to theConstruction, Maintenance
and Use of Large Knowledge Bases",

Thesis: Ph.D. in Computer Science, (July 1976).

HPP-76-8
AIM-286, CS-570
Douglas Lenat,

"AM: An Artificial Intelligence Approach to Discovery in Mathematics
as Heuristic Search",

Thesis: Ph.D. in Computer Science, (July 1976).

HPP~76-9
AIM~291, CS-577
Bruce G. Buchanan, Joshua Lederberg, John McCarthy,

"Three Reviews of J. Weizenbaum’s Computer Power and Human Reason",
(November 1976).

HPP-—76~-10

Bruce G. Buchanan and Dennis Smith,

"Computer Assisted Chemical Reasoning", in Proceedings of the IIL
International Conference on Computers in Chemical Research, Education
and Technology", Pleum Publishing, (1976).

Li
HPP-77-1

STAN-CS-77-593

A. C. Scott, W. Clancey, R. Davis, E. H. Shortliffe,

"Explanation Capabilities of Knowledge-Based Production Systems",
American Journal of Computational Linguistics, Microfiche 62,
Knowledge-Based Consultation Systems, (1977).

HPP-77~-2

STAN-CS-77-589

Robert S. Engelmore and H. Penny Nii

"A Knowledge-Based System for the Interpretatioin of Protein X-Ray
Crystallographic Data", (January 1977).

HPP-77-3
B.G. Buchanan, R. Davis, V. Yu and S. Cohen,

"Rule Based Medical Decision Making by Computer",
(Submitted to MEDINFO.77, 1977).

HPP-77-4

T.M. Mitchell and G.M. Schwenzer,

“Applications of Artificial Intelligence for Chemical Inference.
XXV. A Computer Program For Automated Empirical 13C NMR Rule
Formation", (Submitted to JACS, January 1977).

HPP-77-5
STAN-CS-7 7-596
Mark Stefik and Nancy Martin,

"A Review of Knowledge-Based Systems as a Basis for a Genetics Experiment
Designing System", (February 1977).

HPP-77-6

STAN-CS-77-597

Bruce G. Buchanan and Tom Mitchell.

"Model-Directed Learning of Production Rules", Submitted to the Proceedings

for the Workshop on Pattern-Directed Inference Systems in Hawaii, (February, 1977).

HPP-77-7

H. Penny Nii and Edward A. Feigenbaun,

"Rule-based Understanding of Signals", to be presented at Workshop on
Pattern-directed Inference Systems, (May 1977).

Hpp-77-8

R. Davis,

"Knowledge Acquisition on Rule-based Systems: Knowledge about
Representations as a Basis for System Construction and Maintenance",
submitted to Pattern-Directed Inference Conference, (May 1977).

HPP-77-9

R. Davis,

“interactive Transfer of Expertise I: Acquisition of New Inference
Rules", submitted to Fifth ILJCAL, (August 1977).

12
HPP-77-10

R. Davis,

"A Decision Support System for Medical Diagnosis and Therapy
Selection in Data Base", SIGBDP Newsletter, 8, pp. 58-72,
(Winter 1977).

HPP-77-11

Dennis H. Smith and Raymond E. Carhart,

"Structure Elucidation Based on Computer Analysis

of High and Low Resolution Mass Spectral Data".
Proceedings of the Symposium on Chemical Applications
of High Performance Spectrometry, University of
Nebraska, Lincoln, (1976 in press).

13
Budget
Heuristic Programming Project
Proposal for Renewal of Contract DAHC 15-73-C-0435
July 1, 1977 - June 30, 1979

7-1-77/6-30-78 = 7-1-78/6-30-79

Salaries
Faculty
Feigenbaum, Edward A. 8,089 15,829
Professor
33%, Summer Quarter, 1977
17%, Academic Year, 1977-78
100%, Summer Quarter, 1978
18%, Academic Year, 1978-79

Buchanan, Bruce G. 15,750 16,695
Adjunct Professor
50%, Calendar Year

Michie, Donald - 3,750
Visiting Professor in Artificial
Intelligence
38%, One Quarter

Research Staff
Brown, Dennis L667 4947
Research Associate
100%, Summer Quarter

Creary, Lewis G. 4,375 -
Research Associate
100%,Summer Quarter

Davis, Randall (or replacement) 10,000 -
Research Associate
54%, Calendar Year

Engelmore, Robert 15,120 16,027
Research Associate
50%, Calendar Year

Research Associate (to be named) - 19,000
100%, Calendar Year
Nii, H. Penny 24,538 26,010

Scientific Programmer
100%, Calendar Year

White, William C. 9,896 10,490
Programmer
50%, Calendar Year

Five Student Research Assistants

(to be named) 34,965 37,065

50%, Academic Year; 100% Summer Quarter

Secretarial and Clerical Assistance 9,600 10, 368
100%, Calendar Year

Subtotal, Salaries 137,000 160,181

Total Budget
7-1-77/6-30~79

23,918

32,445

3,750

9,614
4,375
10,000
31,147

19,000

50,548

20, 386

72,030
19,968

297,181
Staff Benefits

19.0% 9-1-78/8-31-77
20.0% 9-1~77/8-31-78
20.8% 9-1-78/8-31-79

Travel

10 West Coast trips
6 East Coast trips
1 Foreign trip

Expendable Supplies and Materials

Telephone, postage, office
supplies, consulting, etc.

Publications and Report Costs

Equipment Rental and Maintenance

Equipment Purchase

Terminal Equipment

Subtotal Direct Costs

Indirect Costs, 58% (excluding equipment)

TOTAL BUDGET

7-1-77/6-30-78

27,126

5,000

7,000
3,000

6,000

7,500

 

192,626
107,374

300 ,000

7-1-78/6~-30-79

33,109

5,000

7,100
3,300

6,500

10,000

225,190

124,810

350,000

7-1-77/6-30-79

60, 235

10,000

14,100
6, 300

12,500

17,500

417,816
232,184

ene

650,000