(126) SECTION II — PRIVILEGED COMMUNICATION BIOGRAPHICAL SKETCH (Give the following informatien for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format for each person.} NAME TITLE BIRTHDATE (Mo., Day, Yr.) Thomas C. Rindfleisch Research Associate 12-10-41 PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY f/f non-U.S&. citizen, SEX indicate kind of visa and expiration date) Oshkosh, Wisconsin, USA USA % Male ClFemate EDUCATION /[8egin with baccalaureate training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Purdue University, Lafayette, Ind. B.S 1962 Physics California Institute of Technology, M.S 1965 Physics Pasadena, CA Ph.D Thesis to ba completed. All course work land examinations completed. HONORS Purdue University, Graduated with Highest Honors, Sigma Xi. MAJOR RESEARCH INTEREST ROLE iN PROPOSED PROJECT Space sciences, computer science and image processing Technical Support RESEARCH SUPPORT (See instructions) RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevant to area of project, List all or most representative publications, Do not exceed 3 pages for each individual.) 1971-Present Stanford University Medical School, Department of Genetics, Stanford, CA. Research Associate ~ Mass Spectrometry, Instrumentation research. 1962-1971 Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA. Relevant Experience: 1969-1971: Supervisor of Image Processing Development and Applications Group. 1968-1969: Mariner Mars 1969 Cognizant Engineer for Image Processing 1962-1968: Engineer - design and implement image processing computer software. 1. Rindfleisch, T. and Willingham, D., "A Figure of Merit Measuring Picture Resolution," JPL Technical Report 32-666, September 1, 1965. 2. Rindfleisch, T. and Willingham, D., "A Figure of Merit Measuring Picture Resolution,” Advances in Electronics and Electron Physics, Volume 22A, Photo-Electronic Image Devices, Academic Press, 1966. RHS-398 ~~. aan (127) Thomas C. Rindfleisch PUBLICATIONS (cont'd) Rindfleisch, T., "A Photometric Method for Deriving Lunar Topographic Information," JPL Technical Report 32-786, September 15, 1965. Rindfleisch, T., "Photometric Method for Lunar Topography," Photo- grammetric Engineering, March 1966. Rindfleisch, T., "Generalizations and Limitations of Photoclinometry," JPL Space Science Summary Volume III, 1967. Rindfleisch, T., "The Digital Removal of Noise from Imagery,'' JPL Space Science Summary 37-62 Volume III, 1970. Rindfleisch, T., "Digital Image Processing for the Rectification of Television Camera Distortions," Astronomical Use of Television-Type Image Sensors, NASA Special Publication SP-256, 1971. Rindfleisch, T., Dunne, J., Frieden, H., Stromberg, W., and Ruiz, R. "Digital Processing of the Mariner 6 and 7 Pictures," Journal of Geophysical Research, Volume 76, Number 2, January 1971. 2 Rindfleisch, T., "Digital Image Processing," To be published, IEEE Special Issue, July 1972. SECTION i! — PRIVILEGED COMMUNICATION (128) BIOGRAPHICAL SKETCH (Give the foltowing information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format for each person, } NAME TITLE BIRTHDATE {Mo., Day, Yr.) Donald C. Harrison Professor of Medicine 2/24/34 PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (/f non-U.S. citizen, SEX i indicate kind of visa and expiration date) u.S. Blount County, Alabama Ss C5 Mate C] Female EDUCATION (Begin with baccalaureate training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Birmingham Southern College, Ala. B.S. 1954 Chemistry Medical College of Alabama M.D. 1958 Medicine HONORS Omicron Delta Kappa, Phi Beta Kappa, Alpha Omega Alpha MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT Computer applications in Cardiology Collaborator RESEARCH SUPPORT (See instructions] Medical Cardiology, HE-5866, NIH, 7/70-6/71, $50,149 15% effort. Evaluation of Cardiovascular System During Various Circulatory Stresses, NGR-05-020-305, NASA, 9/70-8/71, $66,431, 6% effort. Under- graduate-Clinical, HE-5107, NIH, 3/71-2/72, $25,000, 5% effort. Investiga- tive Cardiovascular Physiology & Pharmacology, HE-5709, NIH, 7/68-6/73, $497,835, 17.5% effort. Cardiovascular Adrenergic Receptors-Effects of Drugs, HE-9058, NIH, 9/67-8472, $174,080, 17.5% effort. RESEARCH AND/OR PROFESSIONAL E XPERIENCE (Starting with present position, list training and experience relevant to area of project. List all or most representative publications, Do not exceed 3 pages for each individual.) 1972-. Professor of Medicine, Stanford Univ. School of Med., Stanford, Ca. 1968-72 Associate Prof. of Medicine, Stanford Univ, School of Med. 1967- Chief, Division of Cardiology, Stanford Univ. School of Med. 1965-68 Asst. Prof. of Medicine, Stanford Univ. School of Med. 1964-69 Asst. Program Director, Clinical Research Center, Stanford Univ. 1963-64 Instructor in Medicine and Chief Resident in Medicine, Stanford Univ. School of Med. 1961-63 Clinical Research Associate, National Heart Institute, NIH, Bethesda, Md. 1960-61 Research Fellow, Harvard Medical School, Boston, Mass. 1958-60 Intern and Asst. Resident in Medicine, Peter Bent Brigham Hospital, Boston, Mass. RHS-398 Rev. 3-70 (129) Donald C. Harrison, M.D. Bibliography Stenson, R.E., Crouse, L., Henry, W.L., and Harrison, D.C.: A time-shared digital computer system for on-line analysis of cardiac catheterization data. Comput. Biomed. Res. 1: 605-614, 1968. Henry, W.L., Crouse, L., Stenson, R., and Harrison, D.C.: Computer analysis of cardiac catheterization data. Amer. J. Cardiol. 22:696-705, 1968. Harrison, D.C., and Miller, H.A.: The expansion of a con- ventional cardiac catheterization laboratory to a computer- assisted laboratory. Measurements for Medicine (Hewlett- Packard). 1971 (Booklet) Harrison, D.C., Ridges, J.D., Sanders, W.J., Alderman, E.L., and Fanton, J.A.: Real-time analysis of cardiac catheteri- zation data using a computer system. Circulation 44: 709- 718, 1971. SECTION Il — PRIVILEGED COMMUNICATION (130) BIOGRAPHICAL SKETCH {Give the foliowing information for all protessional personnet listed on page 3, beginning with the Principal Investigator. Use continuation pages and fellow the same general format for each person.} NAME TITLE BIRTHDATE (Mo,, Day, Yr] Stenson, Robert E. Asst. Prof. of Medicine 6/1/38 PLACE OF BIRTH (City, State, Country} PRESENT NATIONALITY (If non-US, citizen, SEX . indicate kind of visa and expiration date) Pennsylvania U.S. 3 Male [_} Female EDUCATION (Begin with baccalaureate training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Massachusetts Institute of Tech. M.S. 1960 Elec. Engr. Harvard School of Medicine M.D. 1965 HONORS Eta Kappu Nu-Honorary Society of Electrical Engineers Tau Beta Pi-Honorary Society of Engineers Sigma Xi-Honorary Scientific Society MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT Computer Applications in Cardio- Collaborator logy RESEARCH SUPPORT (See instructions) RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experiance refevant to area of project. List alt or mast representative publications, Do not exceed 3 pages for each individual.) 1972- Assistant Professor of Medicine, Stanford University School of Medicine, Stanford, Cal. 1971- Clinical Instructor of Medicine, University of California, Davis, Cal. 1970-72 Major USAF, MC, Staff Cardiologist, Travis AFB, Cal. 1969-70 Sr. Resident, Stanford University Hospital, Stanford, Cal. 1967-69 Postdoctoral Fellow, Cardiology Division, Stanford University School of Medicine, Stanford, Cal. 1966-67 Resident, Beth Israel Hospital], Boston, Mass. 1965-66 Intern, Beth Israel Hospital, Boston, Mass. RHS-398 Rev. 3-70 (131) Robert E. Stenson, M.D. Bibliography Stenson, R.E., Crouse, L., Henry, W.L., Harrison, D.C.: A Time-Shared Digital Computer System for on-Line Analysis of Cardiac Catheterization Data: Computers and Biomedical Research 1:605, June 1968. Henry, W.L., Crouse, L., Stenson, R.E., Harrison, D.C.: Computer Analysis of Cardiac Catheterization Data: Am. J. Cardiology, 22:696, Nov. 1968. Stenson, R.E., Constantino, R., Harrison, D.C.: Interrelation- ships of Hepatic Blood Flow, Cardiac Output and Blood Levels of Lidocaine in Man: Circulation 43:205, Feb. 1971. Stenson, R.E., Harrison, D.C.: Cardiac Output: Computer, Dow and Fick. (In press) Cardiovasc. Res., 1972. (132) SECTION I — PRIVILEGED CO!AMUNICATION . BIOGRAPHICAL SKETCH (Give the following information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format for each person.} NAME TITLE BIRTHDATE (Mo., Day, Yr.) Professor of Surgery Chairman, Division of Urology April 26, 1928 Thomas A. Stamey, M. D. PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (/f non-US. citizen, SEX indicate kind of visa and expiration date} Rutherfordton, N.C. USA [iMate (Cl Female EDUCATION (Begin with baccalaureate training and include postdoctorat) YEAR SCIENTIFIC INSTITUTION AND LOCATION OEGREE CONFERRED FIELD Vanderbilt University, Nashville, Tenn. A.B. 1948 Johns Hopkins University School of Medicite M.D. 1952 Medicine Johns Hopkins University School of Med tine, Brady Urological House Staff Residency 8 1952-1956 Urology HONORS Chairman, Comm. Renal Disease and Urology Training Grants, NIAMD, NIH; Member, Advisory Board, USPHS/Coop Study on Renal Disease and Pyelonephritis; Member, National Scientific Advisory Board, National Kidney Foundation; Member, Scientific Advisory Council, No. Calif. Kidney Foundation; Member, Research Comm.; No. Calif. Kidney Fndtn; Editor, Urology Digest; Member, Editorial] Board. Jovest, Urol; Member Editorial Boch, MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT KIDNEY Renal Physiology. Infectious Diseases, Collaborator RESEARCH SUPPORT (See instructions) 2 TO1 AM 05513 -- Training Grant in Urology Period 7/1/71-6/30/76 5 RO] AI 09366 -- Urinary Infection Grant Period 1/1/70-12/31/72 RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevant to area of project. List all or Most representative publications, Do not exceed 3 pages for each individual.) Professor of Surgery, Chairman, Division of Urology Stanford University School of Medicine 1964-present Sabbatical year with Prof. Paul Beeson, Nuffield Dept. of Medicine Radcliffe Infirmary, Oxford, England 1967-1968 Assoc. Professor of Surgery, Chairman, Division of Urology Stanford University School of Medicine 1961-1964 Assoc. Professor of Urology Johns Hopkins University School of Medicine 1960-1961 Asst. Professor of Urology Johns Hopkins University School of Medicine 1958-1960 U. S. Armed Forces, United Kingdom-Urological Consultant 1956-1958 PUBLICATIONS: See list attached RHS-398 (133) THOMAS A, STAMEY, M.D. PUBLICATIONS Books. Renovascular Hypertension. Baltimore: Williams & Wilkins Co., 1963. lst reprinting, Mar. 1967. Urinary Infections. Baltimore: Williams & Wilkins Co. (in press). Chapters in Books Stamey, T.A. and Good, P.H.: Diagnostic tools in the evaluation of renal vascular disease. In: Hypertension, Recent Advances. Philadelphia: Lea & Febiger, 1961, pp. 189-203. Stamey, T.A.: Differential renal function studies. In: Diagnostic Urology: A Handbook of Urologic Diagnostic Technique. Edited by J. Glenn. New York: Harper & Row, Chapt. 9, 1964. Stamey, T.A.: Some observations on the filtration fraction, on the transport of sodium and water in the ischemic kidney, and on the prognostic importance of R.P.F. to the contralateral kidney in renovascular hypertension. In: Ciba Foundation Symposium on Antihypertensive Therapy. Edited by F. Gross. Heidelberg, Germany: Springer-Verlag, 1966, pp. 555-579. Stamey, T.A.: The diagnosis of urinary tract disease in the patient with gastrointestinal symptoms. In: Gastroenterologic Medicine. Edited by M. Paulson, Philadelphia: Lea & Febiger, Chapt. 49, 1969, Palmer, J.M. and Stamey, T.A.: History of differential renal function studies. In: History of Urology. Baltimore: Williams & Wilkins Co. (in press). Meares, E.M. and Stamey, T.A.: Bacterial prostatitis and recurrent urinary tract infection. In: Infectious Diseases. Edited by P.D. Hoeprich. New York: Harper & Row (in press). Stamey, T.A.: Renal vein renins or differential renal function studies in the diagnosis of curable, renovascular hypertension? W.W. Scott - Festschrift, Baltimore: Williams & Wilkins Co. (in press). Scientific Papers Stamey, T.A.: The pathogenesis and implications of the electrolyte imbalance in ureterosigmoidostomy, S&.G. & 0., 103:736-758, 1956. Stamey, T.A. and Scott, W.W.: Ureteroileal anastomosis. S.G. & 0. 104:11-24, 1957, Stamey, T.A., Nudelman, I.J., Good, P.H., Schwentker, F.N. and Hendricks, F.: Functional characteristics of renovascular hypertension. Medicine. 40:347-394, 1961. Stamey, T.A.: The diagnosis of curable unilateral renal hypertension by ureteral catheterization. Postgraduate Medicine, 29:496-504, 1961. Spencer, F.C., Stamey, T.A., Bahnson, H.T. and Cohen, A.: The diagnosis and treatment of hypertension due to occlusive disease of the renal artery. Ann. Surg., 154:674~-697, 1961. ‘Stamey, T.A.: Functional characteristics of renovascular hypertension with emphasis on the relationship of renal blood flow to hypertension. Circ. Res., 11:209-219, 1962. Stamey, T.A. and Pfau, A.: Some functional, pathological, bacteriological, and chemotherapeutic characteristics of unilateral pyelonephritis in man. (two articles: PartI and II). Invest. Urol. 1:134-172, 1963. Pfau, A. and Stamey, T.A.: Some functional characteristics of polycystic renal disease. Invest. Urol., 1:593-603, 1964. SECTION Ul — PRIVILEGED COMMUNICATION (134) BIOGRAPHICAL SKETCH : (Give the following information for all professionat personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format for each person.} NAME TITLE BIRTHDATE (Mo., Day, Yr} Constantinou, Christos E. Research Associate July 21, 1939 PLACE OF BIRTH (City, State, Country} PRESENT NATIONALITY (/f non-U,S. citizen, SEX Limassol, Cyprus indicate kind of visa and expiration date) United Kingdom (TI) (4 Male (_] Femaie EDUCATION (Begin with baccalaureate training and include postdoctoral} YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Borough Polytechnic, London, England HNC 1964 Elect. Engineering Stanford University, Stanford, Calif. M.Sc. 1968 Biomedical Engineering Ph.D. Expected 1972 Biomechanics HORGHE Member, Institute of Electrical and Electronic Engineers MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT Electrophysiology and biomechanics of the Collaborator upper urinary tract. RESEARCH SUPPORT (See instructions) ; NIH Training Grant in Urology - 2 TO1 AM 05513 July 1, 1971 - June 30, 1973 RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevant to erea of project. List alf Or most representative publications, Do not exceed 3 pages for each individual.) 1969- Research Associate, Department of Surgery (Urology), Stanford University 1966-1969 Research Assistant, Department of Surgery (Urology), Stanford University Development of computer based system for the real time collection and analysis of experimental data from the surgical laboratory. Integration and construction of physiological monitoring devices in the study of the dynamics of transport in the ureter. Incorporation of new electrophysiological techniques with bio- mechanical transducers to evaluate static and dynamic parameters of the peristaltis. Cooperation with the Radiology Department in the assessment of contrast media and other methods of visualizing the ureter, in vivo, using the technique described in the list of publications enclosed. Participate in the training of research residents in the quantification of experimental data and teaching in biophysical and biostatistical techniques using the time shared computer. Ph.D. candidate. Biomedical Engineering. 1965-1966 Research Assistant, Microwave Laboratory, Department of Radiotherapy, Laser research on parametric oscillators. RHS-398 Od mae am Christos Constantinou (135) Research Associate Bibliography Chapters in Books Constantinou, C.E., Dale, R.L., Briggs, E.M., and Govan, D.E.: Electro- physiological methods in the study of ureteral dynamics. In URODYNAMICS, ed. Boyarsky, S., Chapter 12, Academic Press, New York, 1971. Constantinou, C.E., Briggs, E.M., Dale, R.L., and Govan, D.E.: Real time digital computer system for ureteral physiology investigation. In URODYNAMICS, ed. Boyarsky, S., Chapter 33, Academic Press, New York, 1971. Scientific Papers Constantinou, C.E. and Briggs, E.M.: Precision electrostatic urine flowmeter. J. Appl. Physiol., 29:396-397, 1970. Constantinou, C.E., Dale, R.L., Briggs, E.M., Perkash, I., Engelsgjerd, G.L., and Govan, D.E.: Dynamics of the upper urinary tract: IT. System for data collection and evaluation. Invest. Urol., 8:645-654, 1971. Dale, R.L., Constantinou, C.E., Briggs, E.M., and Govan, D.E.: Dynamics of the upper urinary tract: II. The effects of an indwelling ureteral catheter on ureteral peristalsis. Invest. Urol., 8:655-672, 1971. Constantinou, C.E., Sands, J.P., and Govan, D.E.: Computer monitoring and control instrumentation in urology research. Proceedings of the 8th Annual Rocky Mountain Bioengineering Symposium. pp. 147-151, 1971. Constantinou, C.E. and Butler, E.D.: Medical application of computer displays in the rapid examination of developing abnormality patterns in the kidney. Digest of Society of Information Display International Symposium, pp. 72-74, 1971. Rosen, D.I., Constantinou, C.E., Sands, J.P., and Govan, D.E.: Dynamics of the upper urinary tract: III. The effects of changes in bladder pressure and volume on ureteral peristalsis. J. Urol., 106:209-213, 1971. Sands, J.P., Constantinou, C.E., and Govan, D.E.: Bladder pressure and its effect on mean arterial blood pressure. Invest. Urol., 10:6~17, 1972. Briggs, E.M., Constantinou, C.E., and Govan, D.E.: Dynamics of the upper urinary tract: IV. The relationship of urine flow rate and rate of ureteral peristalsis. Invest. Urol., 10:18-23, 1972. Abstracts and Demonstrations Butler, E.D. and Constantinou, C.E.: The application of computers to urology. 64th Annual Meeting of the A.U.A., San Francisco, May 1969. Constantinou, C.E., Butler, E.D., and Govan, D.E.: Computer graphic techniques in urologic follow-up of myelodysplasia in children. 39th Annual Meeting of American Academy of Pediatrics, San Francisco, Oct. 1970. Friedland, G.W., Kohatsu, S., and Constantinou, C.E.: Relationship between motility of gastric sling fibers and distal esophagus. Proc. of 18th AUR Symposium. Invest. Radiol., p. 272 5(4)1970. Dale, R.L., Constantinou, C.E., and Govan, D.E.: Dynamics of the upper urinary tract: The effects of acute and chronic obstruction on peristalsis. Presented at the Society of University Urologists - Residents Meeting, New Haven, Conn., May 6-9, 1970. Granato, J.J., Constantinou, C.E., and Govan, D.E.: The effect of radiopaque contrast media on the ureter. Western Section, American Urological Association, Inc. July 2-7, 1972. (136) SECTION 1) — PRIVILEGED COMMUNICATION BIOGRAPHICAL SKETCH (Give the foliowing information for all professional personnel listed on page 3, beginning with the Principal investigator. Use continuation pages and follow the same general format for eech person, | NAME TITLE oc. Dean for Research, BIRTHDATE (Mo, Oay, Yr.) Elliott C, Levinthal SU Med School, Director of IRL April 13, 1922 PLACE OF BIRTH (City, State, Country} PRESENT NATIONALITY (/f non-U.S. citizen, SEX indicate kind of visa and expiration date} Brooklyn, New York id USA (Cd Mate ([} Femate EDUCATION (Begin with baccalaureate training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION AND LOCATION OEGREE CONFERRED FIELD Columbia College BLA. 19h2 Physics Massachusetts Institute of Technology M.S. 1943 Physies and Math Stanford University Ph.d. 1949 Physics and Math HONORS MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT Medical Instrumentaion Research Collaborator RESEARCH SUPPORT (See instructional Contract 952489 Mariner 71 Photo Interpretation, Current Year $71,000 Total $5, 000 Jet Propulsion Lab, 25% time Contract NAS~1-9687 Viking 75 Imaging, Current Year $31,658 Total $297, 805 Langley Res. Center, 20% time Grant NGR 05-020-064-513 Cytochemical Studies in Planetary Microorganisms, Current Year $240,000 Total to date $3, 800,000, 25% time NIH Contract Proposed, Cell Separator Construction, Total $240,000 10% time, no salary Grant GM17 367-03 Automatic Cell Separation - Clinical and Riological Uses, $364, 455, 10% time, no salary (cont'd below) RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present positon, list training and experience relevant to erea of project. List all or most representative publications, Do not exceed 3 pages for each individual.) 1970-present Associate Dean for Research Affairs, Stanford University School of Medicine 1961-present Senior Scientist, Director of Instrumentation Research Laboratory, Dept. of Genetics, Stanford University School of Medicine 1953-1961 President, Levinthal Flectronic Products 1952-1953 Chief Engineer, Century Electronics 1950-1952 Research Director, Member of Board of Directors, Varian Associates 1949-1950 Research Physicist, Varian Associates © 1946-1948 Research Associate, Nuclear Physics, Stanford University 1943-1946 Project Engineer, Sperry Gyroscope Co., New York 1943 Teaching Fellow in Physics, Massachusetts Institute of Technology Research Support (cont'd) Stanford Medical School Associate Dean for Research 25% time Relevant Publications and Papers: (137) E. C. Levinthal,"Detection of Extraterrestrial Life", Professional and Technical Group of Instrumentation and Measurements of I.F.E.E., April, 1963. E. C. Levinthal,"The Detection of Life Within Our Planetary System", Presented at WESCON, August, 1963. E. C. Levinthal, "The Biological Exploration of Mars", Presented at the Space Technology Laboratory's Invited Lecture Series, November 6, 1963. E. C. Levinthal, "The Biological Exploration of Mars", Presented at Moffet Field, Fullerton, Los Angles and San Diego, April 27-30, 1964, as part of the University of California Extension Series Lectures - Horizons in Space Biosciences: Exobiology. E. C. Levinthal, J. Lederberg and L. Hundley, "Multivator - A Biochemical Laboratory for Martian Experiments”, Life Sciences and Space Research II, COSPAR (Committee on Space Research) 1964. B. Halpern, J. W. Westley, E. C. Levinthal, J. Lederberg, "The Pasteur Probe: An Assay for Molecular Asymmetry", Life Sciences and Space Research, COSPAR (Committee on Space Research) 1966. E. C. Levinthal, "Space Vehicles for Planetary Missions", in: Biology and the Exploration of Mars, Nat. Acad. Sei., National Research Council. E. C. Levinthal, "Prospects for Manned Mars Missions", in: Biology and the Exploration of Mars, Nat. Acad. Sci., National Research Council, O. Reynolds, E. Levinthal, G. Soffen, "The Role of the Scientist in Automated Laboratory Systems", AIAA’ Paper No. 67-632, (1967). E. C. Levinthal, J. Lederberg and C. Sagan, "Relationship of Planetary Quarantine to Biological Search Strategy", Presented at COSPAR Meeting (Committee on Space Research), London, (1967) C. Sagan, E. C. Levinthal and J. Lederberg, “Contamination of Mars*", Science, 159: 1191-1196 (1968) E. C. Levinthal, "The Role of Molecular Asymmetry in Planetary Biological Exploration", Gordon Research Conferences, Nuclear Chemistry Section, 1968. (Paper) Relevant Publications (continued) (138) J. P. Kriss, W. A. Bonner, E. C. Levinthal. ‘Variable Time-Lapse Videoscintiscope: A Modification of the Scinti- llation Camera Designed for Rapid Flow Studies." J. Nuclear Med. 10, 249 (1969). W. E. Reynolds, V. A. Bacon, J. C. Bridges, T. C. Coburn, B. Halpern, J. Lederberg, E. C. Levinthal and E. Steed, "A Computer Operated Mass Spectrometer System’ Anal. Chem. 42, 1122 (1970). H. Masursky, R. Batson, W. Borgeson, M. Carr, J. McCauley, D. Milton, R. Wildey, and D. Wilhelms, B. Murray, N. Horowitz, R. Leighton, and R. Sharp, W. Thompson, G. Briggs, P. Chandeysson, and E. Shipley, C. Sagan and J. Pollack, J. Lederberg, E. Levinthal, W. Hartmann, T. McCord, B. Smith, M. Davies, G. DeVaucouleurs, C. Leovy. "Television Experiment for Mariner Mars 1971" Icarus 12, 10-45 (1970). H. Masursky, R. M. Batson, J. F. McCauley, L. A. Soderblom R. L. Wildey, M. H. Carr, D. J. Milton, D. E. Wilhelms B. A. Smith, T. B. Kirby, J. C. Robinson, C. B. Leovy G. A. Briggs, T. C. Duxbury, C. H. Acton, Jr., B. C. Murray, J. A. Cutts, R. P. Sharp, Susan Smith, R. B. Leighton, C. Sagan, J. Veverka, M. Noland, J. Lederberg, E. Levinthal, J. B. Pollack, J. T. Moore, Jr., W. K. Hartmann, E. N. Shipley, G. de Vaucouleurs M. E. Davies. "Mariner 9 Television Reconnaissance of Mars and Its Satellites: Preliminary Results" Science, 175 (4019) 294 (1972). (139) SECTION I — PRIVILEGED COMMUNICATION BIOGRAPHICAL SKETCH (Give the following information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use cantinuation pages and follow the same general format for each person, } NAME TITLE BIRTHDATE {Ma Day, ¥r) Leonard A. Herzenberg Professor of Genetics Nov. 5, 1931 PLACE OF BIRTH (City, State, Country] PRESENT NATIONALITY (If non-US citizen, SEX indicate kind of visa and expiration date) Brooklyn, New York U.S. EXMale C] Female EDUCATION (Begin with baccalaureate training and include postdoc torat} . YEAR SCIENTIFIC ‘NS ! NSTITUTION AND LOCATION DEGREE CONFERRED FIELD Brooklyn College, Brooklyn, New York A.B. 1952 Biology, Chemistry California Institute of Technology , Pasadend Ph.D. 1955 Biochemistry, Pasteur Insti fute, Paris, Postdoctoral fel low Immunology HONORS Phi Beta Kappa, Sigma Xi, . Distinguished Alumnus Award, Brooklyn College, 1970 Genetics Study Section, National Institutes of Health MAJOR RESEARCH INTEREST ROLE iN PROPOSED PROJECT Immunogenetics, somatic cell genetics Collaborator | RESEARCH SUPPORT (See instructions) N.I.H. GM-17367, Automated Cell Sorting~Clinical and Biological Uses, $115,072 current year, total funds for project $364,355. N.I.H. AI-08917, Genetics of Immunoglobulins, $44,044 current year, $240,893 total funds for project period RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, fist training and experience relevant to area of project: List alf or most representative publications. Oo not exceed 3 Pages for each individual. } 1969: present Stanford University School of Medicine, Stanford, California, Professor of Genetics 1964-1969: Stanford University School of Medicine, Stanford, California, Associate Professor of Genetics 1959-1964: Stanford University School of Medicine, Stanford, California, Assistant Professor of Genetics 1957-1959: National Institutes of Health, Bethesda, Maryland. Officer, USPHS (Dr. Harry Eagle) 1955-1957: Pasteur Institute, Paris, France (Prof. Jacques Monod, American Cancer Society Postdoctoral Fellow) 1952-1955: Ph.D. California Institute of Technology, Pasadena, California. (Major: Biochemistry, Prof. H. K. Mitchell; Minor: Immunology, Prof. R. D. Qwen) 1948-1952: A.B. Brooklyn College, New York Publications since 1967: 1. Herzenberg, L. A. and N. L. Warner, 1967.Genetic control of mouse immunoglobulins, p. In 8. Cinader (Ed.), Regulation of the antibody response, Chapter XV. C. C. Thomas, Springfield, Illinois. 2. Tyan, M. L., L. J. Cole and L. A. Herzenberg. 1967. Fetal liver cells: a source of thymus-dependent specific immunoglobulin production in radiation chimeras. Proc. of Sec. of Exp. Biol. & Med. 1161-1163. RHS-398 een — Rev, 3-70 DO NOT TYPE IN THIS SPACE-BINDING MARGIN (140) Continuation page nO. in 12. 13. 14, 15. 16. 17. 18. 9. 20. 21. Klein, J., J. Martinkova & L. A. Herzenberg. 1967. Analysis of the histo- | compatibility-2 (H-2) locus of NZB mice. Transplantation 5: 1335-1337. Klein, J. & L. A. Herzenberg. 1967. Congenic mouse strains with different immunoglobulins allotypes. 1. Breeding scheme, histocompatibility tests and kinetics of ¥G globulin production by transferred cells for C3H. S.W. and its congenic paftner CWB/5. Transpl. 5:1484-1495. Welton, J., S. R. Walker, G. C. Sharp, L. A. Herzenberg, R. Wistar and W. P. Creger, 1968. Macroglobulinemia with bone destruction. Difficulty of distinguishing between macroglobulinemia and myeloma. Amer. J. of Med. 44:280-288. Warner, Noel L. and L. A. Herzenberg. 1967. Immunoglobulin isoantigens (allotypes) in the mouse. IV. Allotypic specificities common to two distinct immunoglobulin classes. J of Immunol. 99:675-678. Minna, J. D., G, M. Iverson & L. A. Herzenberg. 1967. Identification of a gene locus for 6G, immunoglobulin H chains and its linkage to the H chain chromosome region in the mouse. Proc. of Natl. Acad. of Sci. 58:188-194. Tyan, M. L., L. J. Cole & L. A. Herzenberg. 1967. Fetal liver cells: a source of specific immunoglobulin production in radiation chimeras, pp. 87-89. In J. Dausett, J. Hambruger, G. Mathe (Eds.) Advance in transplantation. Proc. Ist Intl. Cong. Transpl. Soc., Paris, June 27-30 (Munksgaard, Publisher). Herzenberg, L. A., Leonore A. Herzenberg, R. C. Goodlin & E. C. Rivera. 1967. Immunoglobulin syntehsis in mice: suppression by anti-allotype antibody. J. ! Exp. Med. 126:701. Herzenberg, L. A. J. D. Minna & Leonore A. Herzenberg. 1967. The chromosome region for immunoglobulin heavy chains in the mouse: allelic electrophoretic mobility differences and allotype suppression. Cold Spring Harbor Symposia on Quantitative Biology 32: 181-186. Herzenberg, L. A. H. O. McDevitt & Leonore A. Herzenberg. 1968. Genetics of antibodies. Ann. Rev. of Genetics 2:209-244. Tyan, M. L. & L. A. Herzenberg. 1968. Ontogeny of the mouse immune system. If. Immunoglobulin-producing cells. J. of Immunol. 101:446-450. Tyan, M. L., H. O. McDevitt & L. A. Herzenberg. 1968. Genetic control of the antibody response to a synthetic polypeptide: transfer of response with spleen cells or lymphoid precursors. Abstract and paper submitted to 2nd Intl. Transpl. Cong. N.Y., Sept. 1968. Herzenberg, L. A. and M. L. Tyan. 1968. Genetics of antibody formation: role of thymus in the evolution of the immune response. 12th Intl. Cong. of Genetics, Tokyo, Japan, Aug. 19-28. Tyan, M. L. & L. A. Herzenberg. 1968. Immunoglobulin production by embryonic tissues: thymus independent. Proc. of Soc. for Exp. Biol. & Med. 128;952-954 Heraenberg, L. A. 1969. Rabbit Aa locus allotypes: quantitative comparisons in IgG, IgA, and IgM by inhibition of precipitation. Fed. Proc., p. 435 (abstract) Hulett, H. R., W. A. Bonner, J. Barrett and L. A. Herzenberg. 1969. Cell sorting: automated separation of mammalian cells as a function of intracellular fluorescence. Science 1663747. Tyan, M. L., L. A. Herzenberg-& P. R. Gibbs. 1969. Lympoid precurosors: thymus independent antibody production. J. of Immunol. 10331283. L'age=Stehr, J. and L. A. Herzenberg. 1970. Immunological memory in mice. I. Physical separation and partial characterizationof memory cells for different Ig classes from each other and from antibody producing cells. J. of Exp. Med. 131:1093-1108. Jacobson, E. B., J. L'age-Stehr & L. A. Herzenberg. 1970. Immunological memory in mice: II. Cell interactions in the secondary immune response studied by means of Ig allotype markers. J. of Exp. Med. 131:1109-1120. Hulett, H. R., L. A. Herzenberg, W. A. Bonner, and P. L. Wolf. Rapid cell- sorter -- a new tool for cell study with clinical applications. Laboratorv Investigations (abstract in press) Presented at 5¥th Annual Meeting of International Academy of Pathology, St. Louis, Missouri, March, 1970. Fru s avo A870 — 78-895 DO NOT TYPE IN THIS SPACE-BINDING MARGIN (141) Continuation page p2. Riblet, Roy J. and L. A. Herzenberg. 1970. Mouse lysozyme: production by a monocytoma, isolation, an comparisons with other lysozyme. Science 168:1595 23. Herzenberg, L. A. Gene interactions in immunoglobulins (in press). Presented at Symposium on Anti-Human Gamma Globulins, Lund, Sweden, Oct. 1969. 24. Herzenberg, L. A. 1970. From cell biology to immunology -- a short trip. J. of Cellular Physiology 76: 303-310. 1971. The antibody response to (T,G) -A--L in tetraparental mice. Federation Proceedings, p. 1531 (abstract). 27. Riblet, R. J., L. A. Herzenberg & L. A. Herzenberg. 1971. Active allotype 28. Bonner, W. A., H. R. Hulett & L. A. Herzenberg. 1971. Highspeed sorting of fluorescence labelled cells. Federation Proceedings, p. EIO. (abstract) 29. Mitchell, G. F., E. 0. Chan, M. S. Noble, I. L. WEissman, R. I. Mishell and in both T-cell and B-cell populations and requirement for T-cell in expression of B-cell memory. Evidence using Anti 6 and anti-allotype sera with congenic mice, J. Exp. Med., in press. of T-cells in antibody production. Presented at the lst International Congres of Immunology, Washington D.C., August, 1971. 31. Herzenberg, Leonore, E. B. Jacobson, L. A. Herzenberg, and R. J. Riblet. 1971. Chronic allotype suppression in mice: an active regulatory process. New York Academy of Sciences. In press. 32. Herzenberg, L. A. 1971. Immunoglobulin genetics in cellular immunology. New York Academy of Sciences. In press. Selected publications before 1967: 1. Herzenberg, L. A. and Leonore A. Herzenberg. 1959. Adaptationto lactose. Nutrition Review 17:65-87. 2. Herzenberg, L. A. 1959. Studies on the induction of beta-galactosidase in a cryptic strain of escherichia coli. Biochimica et Biophysica Acta 31:525-538. 3. Herzenberg, L. A. and Leonore A. Herzenberg. 1961. Association of H-2 antigens with the cell membrane fraction of mouse liver. Proc. of Natl. Acad. of Sci. 47:762-767. 4. Herzenberg, Leonard A. 1962. Part I. Steps toward a gentics of somatic cells 5. CAnn, H. M. and L. A. Herzenberg. 1963. In vitro studies of mammalian somatic cell variation II. Isoimmune cytotoxicity y with a cultured mouse lymphoma and selection of resistant variants. J. of Exp. Med. 117: 267-284. 6. Wunderlich, J. and L. A. Herzenberg. 1963. Genetics of a gamma globulin iso= antigen (allotype) in themuse. Proc. of Natl. Acad. of Sci. 49 3592-598, 7. Erickson, R. P., D. K. Tachibana, L. A. Herzenberg and L. T. Rosenberg. 1964. J. of Immunol. 92:611-615. 8. Hereenberg, L. A. 1964. A chromosome region for gamma 2, and beta 2, globulin H chain isoantigens in th mouse~ Cold Spring Harbor Symposium of Quantitative Biology 29:455-464. Total number of publications: 75. 25. Merrill, J. T., N. Veizades, H. R. Hulett, P. L. Wolf and L. A. Herzenberg. 1971. An improved cell-volume analyzer. Review of Scientific Instruments 42:1157-1163. 26. Bechtol, K. B., T. G. Wegmann, B. W. Chesebro, L. A. Herzenberg & H. 0. McDevitt. Suppression in a cell transfer system. Federation Proceedings, p. 2552. (abstract) L. A. Herzenberg. 1971. Specific immunological memory to heterologous erythrocyt 3 in culture. Part II. Maternal isoimmunization as a result of breeding in the mous A single gene controlling hemolytic complement and a serum antigen in the amouse. ru SHPO. 1470 — 370-408 30. Mitchell, %, F. R. I. Mishell and L. A. Herzenberg. 1971. Studies on the influence | | € (142) BIOGRAPHICAL SKETCH (Give the following information for alt professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and foliow the same general format for each person.) SECTION !f — PRIVILEGED COMMUNICATION NAME TITLE Chiet, Psyt. Research & BIRTHDATE (Mo, Day, Yr.) Bert S. Kopell, M. D. Training Division, VA Hospital Palo Aito, California 2/11/31 PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (/f non-U.S. citizen, SEX New York N ew York indicate kind of visa and expiration date} > USA 4 Male (] Female EDUCATION (Begin with baccalaureate training and include postdoctoral} YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Univ. of Geneva, Geheva, Switzerland Medical Baccalaureate 1953 Medical Sctence Univ. of Geneva, Geneva, Switzerland M. OD. 1958 Maimonides Hospital, New York Rotating 1958-59 lotern ONO chiatry Career Teaching Award--July, 1966 - June, 1968 Diplomate of American Board of Psychiatry & Neurology in Psychiatry, 1966 MAJOR RESEARCH INTEREST ROLE tN PROPOSED PROJECT Electrophysiological Studies of Drugs Collaborator RESEARCH SUPPORT (See instructions) }. Current Research Support a. 20% effort VA Part 1 funds "Electrocortical Measurement of Set and Attention in Psychiatric Patients''. Grant terminates 6/20/72, $15,000 for F. Y. 1972. b. 10% effort to: MH 19918; total direct costs for May 1, 1971 to Apri 30, 1972--$115,062. 2. Pending Applications . a. 40% effort "Brain Responses, Behavior and Drug States in Man: A General Research Proposal''. Total amount requested for current year $154,134. Total requested for a 5-yr. period $635,801. To NIMH and the VA (See Below) RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevant to area of project. List ail or most representative publications. Do not exceed 3 pages for each individual.) 1970-Present Chief, Psychiatry Research & Training Div., VA Hospital, Palo Alto, CA. 1970-Present Assoc. Professor, Stanford University Sch. of Medicine, Dept. Psychiatry 1969-Present Director, Medical Student Training Program in Psych., Stanford Univ. 1968-Present Director, Human Perception Lab., Stanford Univ. Sch. of Med., Dept. Psychi. 1965-1970 Assist. Professor, Stanford Univ. Sch. of Med., Dept. Psychiatry 1964-1966 Research Associate, Palo Alto Veterans Administration Hospital 1964-1965 Instructor, Stanford Univ. Sch. of Medicine, Dept. of Psychiatry 1962-1964 Chief, Psychiatric Services, Westover Air Force Base, Massachusetts 1959-1962 Resident, University of Colorado, Denver, Colorado 1958-1959 Rotating Intern, Maimondes Hospital, New York See representative publications 2. Pending Applications (continued) b. 20% effort ''Brain Responses in Alcoholics During Drinking Cycle. Total amount requested for current year $73,607. Total requested for a 3-yr. period $222,699. Submitted to NIMH. RHS-398 Rev. 3-70 Bert S. Kopell, M. D. (143) PUBLICATIONS Stilson, D. W. and Kopell, B.S. The recognition of visual signals in the presence of visual noise by psychiatric patients. J. Ner. Ment. Dis., 139- 209-221, 1964. Kopell, B. S., Noble, E. P. and Silverman, J. The effect of thiamytal and methamphetamine on the two-flash fusion threshold. Life Sciences, 4: 2211-14, 1965. Stilson, D. W., Kopell, B. S., Vandenbergh, R., and Downs, M P. Perceptual recognition in the presence of noise by psychiatric patients. J. Nerv. Ment. Dis., 142: 235-247, 1966. Noble, E. P., Silbergeld, S., Kopell, B. S., McKinney, W., Wittner, W. K., and Butte, J. C. The effects of physiologic doses of corticosteroid on catechola- mine metabolism in man. J. Psychiat. Res., 6: 159-167, 1968. Kopell, B. S. and Wittner, W. K. The effects of chlorpromazine and methampheta- mine on visual signal from noise detection. J. Nerv. Ment. Dis., 147:418-24, 1968. Hilf, F. and Kopell, B. § Non-contingent reinforcement and certainty. Psychonomic Science, 1]: 211-213, 1968. Macpherson, L. and Kopell, B. S. Systems approach to the measurement of Slow evoked potential changes. Med. Biol. Eng., 6: 673-65, 1968. Kopell, B. S., Lunde, D. T., Clayton, R. B., and Moos, R. H. Variations in some measures of arousal during the menstrual cycle. J. Nerv. Ment. Dis., 148: 180-187, 1969. Moos, R. H., Kopell, B. S., Melges, F. T., Yalom, I. D., Lunde, D. T., Clayton, R. B., and Hamburg, D. A. Fluctuations in symptoms and mood during the menstrual cycle. J. Psychosom. Res., 13 37-44, 1969. Kopell, B. S., Wittner, W. K. and Warrick, G. The effects of stimulus differ- ences, light intensity and selective attention on the amplitude of the visual averaged evoked potential in man. Electroenceph. Clin. Neurophysiol., 26:619-22, 1969. Kopell, B. S. The role of progestins and progesterone in brain function and be- havior. In The Metabolic Effects of Gonadal Hormones and Contraceptive Steroids, Hilton A. Salhanick (ed.), New York: Plenum Press, 1969. Kopell, B. S., Wittner, W. K., Lunde, D. T., Warrick, G., and Edwards, D. Cortisol effects on the averaged evoked potential, alpha rhythm, time estimation, and the two-flash fusion threshold. Psychosom. Med., 32: 39-49, 1970. Roth, W. T. and Kopell, B S$. The auditory evoked response to repeated stimuli during a vigilance task. Psychophysiology, 6: 301-309, 1969. Hilf, F. D., Wittner, W. K., Kopell, B. S. Feedback utilization styles of Paranoid patients. J. Nerv. Ment. Dis., 149: 491-495, 1969. Roth, W. T., Kopell, B. S., and Bertozzi, P. E. Effects of attention on averaged evoked response to speech sounds. Electroenceph. Clin. Neurophysiol., 29: 38-46, 1970. (144) Bert S. Kopell, M. D. Publications Continued Kopell, B. S , Wittner, W. K., Lunde, D. T., Warrick, G. and Edwards, D. Influence of triiodothyronine on selective attention as measured by the averaged evoked potential in man. Psychosom. Med., 32: 495-502, 1970. Zarcone, V., de la Pena, A., Kopell, B. S., and Dement, W. Visual evoked response following REM deprivation. Psychophysiology, 7: 301, 1970. Kopell, B. S., Zarcone, V., de la Pena, A., and Dement, W. C Changes in selective attention as measured by the visual averaged evoked potential following REM deprivation in man. Electroenceph. Clin. Neurophysiol., 32: 322-325, 1972. Macpherson, L., Hutchings, M. D., and Kopell, B. S. An electrically operated skin resistance switch. Psychophysiology, 8: 673-675, 1971. Macpherson, L. and Kopell, B. S. A zero-setter and voltage reference unit for EEG amplifier systems. Psychophysiology, in press. (1972). Tinklenberg, J. R., Kopell, B. S., Hollister, L. E., and Melges, F. T. A comparison of the effects of marihuana and ethanol on memory, evoked potential, and contingent negative variation. Psychopharmacology Bulletin, in press. (1972). Corby, J. C. and Kopell, 8. S$. Blink and eye movement EEG artifacts. Psycho-~ pyhsiology, in press. (1972). Kopell, B. S., Maxim, P., and Koran, L. Influence of lithium on selective attention as measured by the averaged evoked potential in man. Submitted and accepted for publication by Psychopharmacologia. Kopell, B. S., Wittner, W. K., Lunde, D. T., and Wolcott, L. L. Effect of amphetamines and barbiturates on selective attention as measured by the averaged evoked response. In preparation. Kopell, B. S , Tinklenberg, J. R and Hollister, L. E. Effects of marijuana and alcohol on the contingent negative variation. In preparation. To be sub- mitted to Archives of General Psychiatry. Kopell, B. S., Wittner, W. K., and Lunde, D. T. Influence of amphetamines and barbiturates on contingent negative variation. In preparation. To be sub- mitted to Psychopharmacologia. Corby, J. C. and Kopell, B. S. Effect of predictability on evoked response enhancement in selective attention. In preparation. Lunde, D. T., Costell, R., Wittner, W. K. and Kopell, B. S. The electro- corticol expression of sexual object preference in non-deviant male and female subjects. In preparation. To be submitted to Science. Moos, R., Clayton, R., Kopell, B. S$. and Hamburg, D. A. Progesterone and menstrual cycle symptomatology. In preparation. SECTION f! — PRIVILEGED COMMUNICATION (145) BIOGRAPHICAL SKETCH (Give the following information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the sarne general format for each person,} NAME TITLE . . BIRTHDATE [Mo., Day, Yr) Chief of Psychiatric Walton T. Roth, M.D. Consultation Services 2/23/39 PLACE OF BIRTH (City, State, Country] PRESENT NATIONALITY (if non-US citizen, SEX L indicate kind of visa and expiration date) Topeka peka, Kansas USA {xl Mate 1} Female EDUCATION (Begin with baccalaureate training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Harvard College B.A. 196] Biochemistry New York University School of Medicine M.D. 1965 HONORS Harvard National Scholar, 1957-196] Diplomate of American Board of N.Y.U. Merit Scholar, 1961-1965 Psychiatry and Neurology in AOA Medical Honor Society, elected 1965 Psychiatry, 1972 MAJOR RESEARCH INTEREST : ROLE IN PROPOSED PROJECT Human Electrophysiology Collaborator RESEARCH SUPPORT (See instructions) 1. Current Research None 2. Pending Applications a. 50% effort ''Brain responses in alcoholics during drinking cycle''. Total amount requested for current year $73,607. Total requested for a 3-year period $222,699. Submitted to NIMH. b. 50% effort ''Brain responses, behavior and drug states in man: a general research proposal'', Total amount requested for current year $154,134. Total requested for a 5-year period $635,801. To NIMH and VA. RESEARCH AND/OR PROFESSIONAL E XPERIENCE (Starting with present position, list training and experience retevant to area of project, List all or mast representative publications, Do not exceed 3 pages for each individual. } 1971 - Present Chief of Psychiatric Consultation Services, V.A. Hospital, Palo Alto, Ca. 1969 - 197] National Institutes of Mental Health, Clinical Associate 1966 - 1969 Resident in Psychiatry, Stanford Hospital 1965 - 1966 Intern in Medicine, North Carolina Memorial Hospital 1964 National Science Foundation Summer Fellowship, The Worcester Foundation for Experimental Biology 1960 National Science Foundation Summer Fellowship, Harvard See Representative Publications RHS-398 Rev. 3-70 (146) Publications, Walton T. Roth, M.D. Roth, W.T. The effect of LSD, mescaline, and d-amphetamine on the evoked ‘'secondary discharge’. Psychopharmacologia (Berl.), 9: 253-258, 1966. Roth, W.T. and Kopell, B.S. The auditory evoked response to repeated stimuli during a vigilance task. Psychophysiology, 6: 301-309, 1969. Roth, W.T., Kopell, B.S., and Bertozzi, P.E. The effect of attention on the average evoked response to speech sounds. Electroenceph. clin. Neurophysiol., 29: 38-46, 1970. Stillman, R., Roth, W.T., Colby, K.M., and Rosenbaum, C.P. An on-line computer system for initial psychiatric inventory. Amer. J. Psychiat., 125: 7, Jan. 1969 suppl., 8-11. Roth, W.T. and Cannon, E.H. Some features of the auditory evoked response in schizophrenics. Arch. Gen. Psychiat., in press, 1972. Roth, W.T., Galanter, M., Weingartner, H., Vaughan, T., and Wyatt, R. The effect of marijuana and synthetic delta-9-THC on the auditory evoked response and background EEG in humans. Submitted for publication, 1972a. Roth. W,T. Auditory evoked responses to unpredictable stimuli. Submitted for publication, 1972b. (147) SECTION I! — PRIVILEGED COMMUNICATION BIOGRAPHICAL SKETCH (Give the following information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format for each person.) NAME TITLE BIRTHDATE (Mo., Day, Yr.} Ronald D. Jamtgaard Facility Director (ACME) May 2, 1933 PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (f/f non-U.S citizen, SEX indicate kind of visa and expiration date) Sioux Falls, South Dakota USA EXMate (] Female EDUCATION (Begin with baccalaureate training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Augustana College, Sioux Falls, S.D. University of Minnesota A.B. 1957 University of Minnesota coursework for M.A. in Pub. Admin. HONORS MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT Biomedical computing, communications systems Management Support RESEARCH SUPPORT (See instructions) ACME Computing Facility, Stanford School of Medicine 95% time RROO411 S.U. Medical Center Computer Planning Funds 5% RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevant to area of project, List all or most representative publications, Do not exceed 3 pages for each individual.) 1970-present Director, Advanced Computer for MEdical Research (ACME) Stanford Medical School, Stanford Computation Center, Stanford University. 1969-1970 Manager of Administrative Services, Radiation Division, Varian Associates, Palo Alto, California. 1967 -1969 Inter-Facility Associate Director, Stanford Computation Center, Stanford University. 1966- Executive Assistant to Director (Dr. W.K.H. Panofsky) Stanford Linear Accelerator Center, Stanford University. 1961-1966 Budget Officer, Stanford Linear Accelerator Center, Stanford University. 1958-1961 Management Trainee, Field Office Liaison Officer and Pudget Analyst U.S. Atomic Energy Commission at Germantown, Maryland, and Idaho Falls, Idaho. RHS-398 Rev. 3-70 (148) St -_ “thy LEGED COMMUNICATION BIOGRAPHICAL SKETCH {Give tha follawing information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format far each person. | NAME THTLE BIRTHDATE (Ma, Day, ¥r.) . . Lecturer, Consultant, and June 2h, 1936 Gio C.M. Wiederhold le ~ .? , 3 wernior Systems Designer PLACE OF BIRTH {City, State, Country} PRESENT NATIONALITY (/f non-U.S citizen, SEX indicate kind of visa and expiration date} Varese, [taly Permanent Resident Alien CJ Male () Femaie EDUCATION (Begin with baccalaureate training and include postdoctoral} YEAR SCIENTIFIC INSTITUTION AND LOCATION OEGREE CONFERRED FIELD IMS Technicum, Rotterdam, Holland B.S. 1957 Aeronautical Eng. U.C. Berkeley, Calif. 1960-64 Coursework in heu- risti ropramming Comp! Ter destin, Bte. HONORS Graduated cum laude from TMS Technicun. Listed in WHO's WHO IN AMERICA, vol . 35, 1968-69. MAJOR RESEARCH INTEREST ROLE iN PROPOSED PROJECT Use of computers in data reduction and medil- Technical Staff cal applications of computers. RESEARCH SUPPORT (See instructions) ACME Computing Facility, Computation Center, Stanford University. Supported under the Biotechnology Resources Branch of NIH, Grant No. RROO311-06.(30% time) Department of Surgery, Div. of Cariovascular Surgery, S.U. Medical Center, Stanford University, consultant. (10% time) Hospital Data Processing, S.U. Hospital, Stanford University, technical eer ’ (60% time RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training end experience relevant to area of project. List all or most representative publications, Do not exceed 3 pages for each individual.) 1970-present: User Services Manager, ACME and consultant to Director, SU. Hospital, ADP. 1965-70: Director, ACME Facility, Stanford Computation Center. 1965-present: Lecturer, Computer Science Dept., Stanford University. 1964-65: Visiting Professor, Indian Inst. of Technology, Kanpur, India under USAID. 1961-64: Head of Programming, U.C. Berkeley, Calif. 1958-61: IBM Service Bureau Corp., New York and San Jose, Programmer. 1958: SHAPE Air Defense Technical Center, Europe - technical assistant. Consultant to American Cyanamid Co. (1961-date); Optimum Systems Inc. (1967-date); Syntex Corp. (1968); U.C. Berkeley Center for Research and Management Science ( 1968-69) Reeves Telecom Corp., N.Y. and Detroit (1969-70), Consultant, National Center for Health Services, USPHS. Consultant, Polymorphic Corp., Palo Alto, Calif. Bibliography: 1) Wiederhold, G., Loewner, P. et al.: CSI/CSO Insurance Rate Tables. SBC Corp., 1959. 2) Wiederhold, G. and Tsao, C.C.: A program for eValuation equilibrium combustion. Kinetics, Equilibrium and Performance of High-Temperture Systems, 1962. 3) Wiederhold, G. and Potter, R.L.: Computation of the equilibrium composition of multi-component chemical systems. American Cyanamid Co., Stamford, Conn., 1962. 4) Wiederhold, G.: Control language for an interactive time-sharing system. SHARE TSS/67 Control Language Comm., 1966. (continued) RHS395 Rew. 3-70 (149) Gio C. M. Wiederhold, B.S. 2 Bibliography (continued) 5) 6) 10) 11) 12) 13) 14) 15) 16) 17) 18) 19) Wiederhold, G.; Internal Documentation, U.C. Computer Center, Berkeley, Calif., 1962-65. FORFOR: A timesharing compiler system design; programming using Assembly Macros; FXMS: An error traceback procedure for FORTRAN IV and MAP Programs; MORT: A col- lection of Text Manipulating Procedures; Proposal for simple system allowing direct access to the computer; STUDENT: A Fast FORTRAN IV Compiler. Wiederhold, G.: A Summary of the ACME System. ONR Computer and Psychobiology Conference Proceedings, Monterey, Calif., May 17, 1966. Wiederhold, G.: A Summary of the ACME System. Conversation with a 50 Conference Proceedings, Chicago, Ill., October 31 ~ November 1, 1966. Sanders, W.J., and Wiederhold, G., et al.: An Advanced Computer System for Medi- cal Research. AFIPS Conference Proceedings 31, Anaheim, Calif., 1967. Brietbard, G.Y., and Wiederhold, G.: PL/ACME: An Incremental Compiler for a Sub- set of PL/1. IFIP68 Congress Proceedings, Edinburgh, Scotland, August 1968. Wiederhold, G. and Hundley, L.: A Time-Shared Data Acquisition System. Digest 1969 IEEE Computer Group Conf. on Real-Time Systems, IEEE, Minneapolis, Minn., pp. 190-196, June 1969. Wiederhold, G.: Setting Up a General Purpose Data Acquisition System. Proceedings of IBM Scientific Computing Symposium on Computers in Chemistry, Data Processing Division, White Plains, New York, August 1969. Wiederhold, G.: An Advanced Computer System for Medical Research. Proceedings of IBM Japan Computer Science Symposium, Research and Computer System, Tokyo, Japan, pp. Bl-B15, November 1969. Crouse, L. and Wiederhold, G.: An Advanced Computer System for Real-Time Medical Applications. Computer in Biomedical Research (Academic Press), vol. 2, 6, December 1969. Wiederhold, G.: Internal Documentation (ACME Notes), Stanford Computation Center, ACME Computer Facility, Stanford, Calif., November 1965 - present. Wiederhold, G.: Medical Uses of Computer (in Japanese) presented in Tokyo, Japan, November 1969, published in IBM Review No. 27, February 1970. Wiederhold, G., Brietbard, G.: A Method for Increasing the Modularity of Large Systems. IEEE Computer Group News, vol. 3, 2, March-April 1970. Girardi, S., Frey, R., Wiederhold, G.: A Filing System for Medical Research. Pre- sented at Journees Internationales d'Informatique Medicale de Toulouse, France, March 4-6, 1970, and at The Eighth Annual Symposium on Biomathematics and Computer Science in the Life Sciences, Houston, Texas, March 23~24, 1970. Crouse, L. and Wiederhold, G.: Interactive Use of a Timesharing System for Medical Laboratory Supports, San Diego Biomedical Symposium Computing On-Line, April 6-8, 1970. Wiederhold, G., and Ehrman, J.: An inferred syntax and semantics of PL/S. Sub- mitted to Sigplan Notices, A Journal of the ACM, September 1971. (150) SECTIC . 1, — PRIVILEGED COMMUNICATION BIOGRAPHICAL SKETCH (Give ths following information for all professional personnel listed on page 3, beginning with the Principal investigator. Use continuation pages and follow the same general format for each person, } NAME TITLE BIRTHDATE (Ma, Day, Yr.) Hundley, Lee Assistant Director, ACME danuary 31, 1941 PLACE OF BIRTH (City, State, Country) PRESENT NATIONALITY (/f non-U.S. citizen, SEX indicate kind of visa and expiration date} Dallas, Texas USA Mate ()Femate EDUCATION (Begin with baccalaureate training and include postdoctorat) YEAR SCIENTIFIC INSTITUTION AND LOCATION DEGREE CONFERRED FIELD Southern Methodist University, Dallas, Té¢x. B.S. 1960 Electrical Engineer San Jose State College, S.J., Calif. coursework for MA HONORS Sigma Tau - Engineering Honorary Fraternity Eta Kappa Nu - Electrical Engineering Honorary Fraternity Graduated second in a class of 92 from Southern Methodist University MAJOR RESEARCH INTEREST ROLE IN PROPOSED PROJECT Biomedical Computing Applications Technical Staff RESEARCH SUPPORT (See Instructions) ACME Computing Facility, Stanford School of Medicine 100% time RROO411 RESEARCH AND/OR PROFESSIONAL EXPERIENCE (Starting with present position, list training and experience relevent to srea of project, List all or most representative publications. Do not exceed 3 pages for each individual.) 1967-present Assistant Director ACME Computing Facility, Stanford University 1966-67 Manager, Systems Engineering-Programming Manager, Data Pathing, Los Altos, Calif. 1961-1966 Research Engineer, Instrumentation Research Laboratory, Genetics Department, Stanford School of Medicine. 1959-1961 Research Scientist, University of Texas Southwestern Medical School. Re, DP, (151) Publications: Montgomery, P. O'B. and liundley, L. L.: "The Use of Television in Scanning Techniques for Ultraviolet Irradiation of Cells." Digest of Technical Papers, 12th Annual Conference on Electrical Teconiques in . Med. and Biol. November 10-12, 1959, 19. Hundley, L. L. and Montgomery, P. O'B: "Flying Spot Techniques in Microscopy." Digest of Technical Papers, 12th Annual Conference on Electrical Techniques in Med. & Biol. November 10-12, 1959, 20-21, Montgomery, P. O'B. and Hundley, L. L.: "The Use of Television and Scanning Techniques for Ultraviolet Irradiation Studies of Living Cells." IRE Trans. Med. Electr. ME 7:135-138 July 1960. Montgomery, P. O'B. and Hiundley, L. L.: "The Effects of Selective Ultraviolet Irradiation of the Cytoplasm of Living Cells." Proc. Soc. Exp. Bio. & Med. 105:117-120, Oct. 1960. Montgomery, P. O'B., Bonner, Wm. A. and Hundley, L. L.: "Flying Spot Microscopy." Encyclopedia of Microscopy, Edited by George L. Clark, Reinhold Publishing Corp. pp. 334-338, 1961. Montgomery, P. O'B. and Hundley, L. L.: "Ultraviolet Microbeam Irradiation of the Nucleoli of Living Cells." Exp. Cell Res. 24:1-5, 1961. Montgomery, P. O'B., Bonner, W. A., Hundley, L. L. and Ashworth, C. T.: "Biological Effects of U. Vv. Irradiation in Chaos Chaos." Royal Microscopical Society. 80:19-24 (PT I) April 1961. Montgomery, P. O'B. and Hundley, L.L.: "A Flying Spot Interference Television Microscope." Nature. 192:4807, 1059-1060, December 1961. Montgomery, P. O'B., Van Orden, F., Hundley, L. L., Chapman, C. L. and Cook, 3. E.: "Effects of Selective Ultraviolet Irradiation of the Nuclei of Living Cells." Proc. Soc. Exp. Biol. and Med. 108:2, 372-375, Nov. 1961. Hundley, L. L.: "A Flying Spot Interference Microscope." Annals of the New York Academy of Sciences, Vol. 97, Art. 2, pages 514-515, June 5, 1962. Levinthal, E., Hundley, L. L., and Lederberg, J.: Life “Sciences and Space Research II: "Multivator - A Biochemical Laboratory for Martian Experiments," North Holland Publishing Company, June 3-12, 1963. Hundley, Coburn, Garwin and Stryer: "A Nanosecond Fluorimeter." Review of Scientific Instruments, 38-488-1967. Wiederhold, Gio, Lee Hundley: "A Time-Shared Data Aquisition System” Proceedings of the IEEE. Computer Group Conference, March 1970 SECTION I — PRIVILEGED COMMUNICATION (152) BIOGRAPHICAL SKETCH (Give the following information for all professional personnel listed on page 3, beginning with the Principal Investigator. Use continuation pages and follow the same general format for sech person} NAME Regina Frey TITLE BIRTHDATE (Ma, Day, Yr.) Systems Programmer September , 1937 PLACE OF BIRTH (City, State, Country) Newton County, Indiana PRESENT NATIONALITY (ff non-U.S citizen, SEX indicate kind of visa and expiration date) USA Oj Male _fiFemasie EDUCATION (Begin with baccalaureste training and include postdoctoral) YEAR SCIENTIFIC INSTITUTION ANDO LOCATION DEGREE CONFERRED FIELD Purdue University, Lafayette, Indiana B.S. 1959 Mathematics HONORS General Motors and Purdue University Alumni Association Scholarships MAJOR RESEARCH INTEREST Biomedical systems computing RESEARCH SURPORT (See instructions) ROLE IN PROPOSED PROJECT Technical Staff ACME Computing Facility, Stanford University School of Medicine 100% time NIH BRR Grant RROO311 RESEARCH AND/OR PROFESSIONAL E XPERIENCE (Starting with present position, list training end experience relevant to area of project, List ail or most representative publications, Da not exceed 3 pages for each individual.) 1968-present Systems programmer, ACME Facility, Stanford Computation Center, c Stanford University . 1964-1967 Programmer, University of California at Berkeley, Linguistics Dept. 1959-1964 Programmer-Analyst, Systems Development Corporation, Santa Monica, Calif. Education 1959: Programmers Training School, System Development Corporation 1970: Systems Science II, IBM Education Papers A Filing System for Medical Research, coauthored, BIOMEDICAL COMPUTING, vol. 2, 1971, Elsenier Publishing Company, Ltd., England. HS-355 Rev. 3-70