PUBLIC HEALTH SERVICE NATIONAL INSTITULES OF HEALTH - DEPARTMENT OF HHALTH, EDUCATION, AND WELEPARE SPECIAL RESEARCH RESOURCE ANNUAL, REPORT Report Period: o C arom: August 1, 1967 mo/dey/year (same as current 12-month To: budget period) July 31, 1968 mo/day/year Grant No. FR 00311-02 Resource Title Advanced Computer for MEdical Research (ACME) Resource Adaress Stanford University School of Medicine Palo Alto, California Resource Tel. No. (415 )321-2300 Ext. 5818 Principal Investigator Lederberg, Joshua Title Professor Acedemic Dept. Genetics Grantee Institution Stanford University Sehool of Medicine Type of Institution (Private Univ., State Univ., Hosp., etc.) Private Investigator's Tel. No. (415 )321-2300 Ext. 5049 Name of Institution's Special Research Resource Advisory Committee: Computer Policy Committee Membership of Special Research Resource Advisory Committee (Indicate Chairman) Name Title Department see next page Institution Typed Name & Title of Principal Investigator Signature Date Joshua Lederberg, Professor Typed Name & Title of Grantee Institution Signature Date Official ACME Policy Committee J» Weldon Bellville, M.D. Professor of Anesthesia Edward Feigenbaum, Ph.D. Director, Stanford Computation Center Robert J. Glaser, M.D. Vice-President for Medical Affairs, Dean of the School of Medicine and Professor of Medicine Keith F. Killam, Ph.D. Professor of Anatomy Joshua Lederberg, PheD., Committee Chairman Professor of Genetics and Biology, and Executive Head, Department of Genetics * Frank Morrel, M.D. Professor of Medicine and Head, Division of Neurology Lincoin E. Moses, Ph.D. Professor and Executive Head, Dept. of Statistics; Associate Dean, Humanities and Sciences; Professor of Preventive Medicine Lawrence J. Schneiderman, M.D. Assistant Professor of Medicine (Ambulatory Medicine) RK Anthony M. Tannone, M.D. Associate Professor of Medicine (Neurology), and Acting Head (67-68), Division of Neurology Lubert Stryer, M.D. Associate Professor of Biochemistry Emmanuel Mesel, M.D. Assistant Professor of Pediatrics Gio Wiederhold Associate Director for the Real-Time Facility * Sebbatical Leave 67-68 xt Substituting for Dr. Morrel Stanford University Grant No. FR 00511-02 Advanced Computer Sor Medical Research Section I-A General Descripticns of Resource Operations This report covers the period from June 1, 1967, the date of the preceding report, to April €O, 1968. The past year has seen the development of the ACME system from 2 vrimitive calculator system to one of the most powerful timesharing systers operating today. During this second year there was no change in the organizational status of the resource. The entire ACME Facility operates eas one of the Stanford Computation Center facilities and received administrative assistance and technical information through SCC's central offices. ACME is housed in the medical school, however, and operates on an indevendent budget, and its professional staff is solely responsible to the medical school and the needs of medical researchers, as represented by the Medical Computer Committee. Development of Service Facilities The initial services ACME provided were miscellaneous batch-type operations while the system was being developed. In May 1967, ACME had started providing calculating services at remote terminals. In July programs could be saved in ACME files and kept available for later use. In August single user data acquisition into the system was provided while other users were calculating. The ACME display was used for the first user project in September. In October small computers could be serviced by the ACME system; and since November, data storage is provided in ACME, In February the system started providing data acquisition service for multiple users. Facilities for reading cards into the system also became available in February. Current Status of Facilities The size and complexity of programs that ACME can handle has increased Steadily so that a number of programs currently in use at ACME are larger than could be handled in 7090-size equipment. Since no timesharing alterna- tives of similar scope exist yet at Stanford, which was one of the expecta- tions when the provosal for the ACME system was made Originally, the system services a larger cuantity of statistical and data manipulation needs than was originally expected. This has slowed down the development of ACME's capabilities for reeltime data acquisition and control. Currently, the system has the capability to handle up to 30 users operating simultaneously. Of these, up to four can use the data acquisition facilities provided by the time-shared 1800. These four share 12 data channels and an aggregate data rate of up to 6000 samples per second. In addition, four data channels are available for high-speed transmission to or from instruments to the 360 processor. However, new high speed applications are still scheduled outside of normal operating hours until they have proven that they do not introduce errors or problems in the overall system. Small computers can be serviced routinely and four of these we connected to ACME, + Future Development Needs Only two major additions are contemplated to the basic timesharing system: the implemention of external subroutines and prevision for double precision arithmetic. The realtime aspects of the system will require further develop- ment since they are lagging very much behind current demands. The other issue is system reliability. Even ugZn the numb system er of “or batch operating systems i a -“y and the failure rate a single failure is felt by many users immed LU OC TOLSrs has to be an order of magnitude Less -t Development of the real-time facilities need inuing effort. Both the number of simultaneous users and lines, ageregs data rates, and system response times are less than the demand put on tne system by the medical school. Within the current hardware* we hope to te able to handle ?2 users sharing a 20-ke aggregate rate on the 1800--as well as allow slow-rate collection of data over 24 hours periods. Development of Usage of the System We began collecting usage records in September 1967. The table below shows a steady increase of usage over the period of overation. The exceptions in December and January/February are due to major croblems that we experienced, mainly with the IBM data cell, which has now been replaced. The detailed accounting covers only actual accounting records, beginning in October when our summary accounting procedure came into operation. o 0) On the detailed usage listing there is an entry for MISC. USERS (no files). This is the total for the many small occasional users--mainly students--who do not keep permanent records in ACME, Neitner does ACME keep permanent individual records of their usage. We have designed our system so that no record is produced when 2 user's run is terminated due to system failure. In an on-line system this does not mean that all the time is wasted. SUMMARY OF USAGE DEVELOPMENT Month and Days Daily Account Account Estimated Usage Scheduled Records Days based on 30 days service Missing Console’ Page Console Page Hours Minutes Hours Minutes Sept 1 to 40 13-1800 78% 220,376 783 220,000 Oct 1 to 41 11-1800 766 260 , 283 766 260, 000 Nov 1 to 40 7-14.30 1800-2200 983 553,936 7% 12°27 460,000 Dec 1 to 41 7-14.40 1800-2200 705 eg7 432k 705 247 , 000 Jan 1 to 20 7-14.30 1800-2200 918 403,649 1377 606,000 Jan 21 to Feb 20 7-15.30 18, 40-2200 1056 431,649 6* 1267 518,000 Feb 21 to Mar 20 - F-15.40 18.30-2200 1966 826,350 1966 826,000 Mar 20 to Apr 20 7-15.20 18.30-2200 1274 639,826 10* 1911 960, 000 * Our usage record system uses IBM's operating system files for its record-keeping functions. Unfortunately, there is an error in this system which has caused us to lose our accounting records three times. A fix is promised by IBM by June, therefore tabulated usage figures in the estimate columns above compensate for the lost days — 2 Current Problems Now that the ACM® system has developed to a desirable level for the users, reliability becomes of prime concern. Hardware Hardware reliability is largely out of ACME control. The ACME staff is trying to develop a better understanding with IBM of the needs posed by real- time operations. A major source of unreliability, the data cell, has been replaced. Higher data acquisition rates, however, are still prone to induce failures in the central processor. software Software reliability, on the other hand, is under ACME control. The staff continues to redesign some system areas that are prone to failure. In addition, the rate of change in our basic system software is slowing down considerably, with resultant positive effects. Failsoft In addition, work has been going on and is expected to continue to minimize the effects of both hardware and software failures. Part. of the effort is in obtaining control from IBM code when a failure is signalled, and limiting the interruption to one user. Another part consists of utility programs that repair files and programs when a failure has been serious. Presentations Even though the ACME project has been productive less than a year, its existence and design are becoming well known. The ACME project is described in an IBM-distributed film on data acquisition. This film is also scheduled for showing on the educational television net- work. Another film was made at ACME and shown in Washington for the benefit of IBM salesmen. ACME will also be on NBC nationwide television May 2lkth as part of a Frank McGee program on the future of medicine. Presentations describing the system have been made at: IBM customer executive class, San Jose, October 6, 1967 (G. Breitbard). Katholischore Unversteit, Nymegen, Holland, November 6, 1967. California Nurses Association, Sacramento, California, November 19, 1967. Cornell Medical School, New York, January 25, 1968. IBM Computer Center directors’ executive class, Poughkeepsie, New York, January 26, 1968. SHARE PL/I Committee, Houston, Texas, March 1968. Johns Hopkins University, Baltimore, Maryland, May 3, 19 Johns Hopkins Hospital, Baltimore, Maryland, Mey 3, 1968 68. ar . Brooklyn Polytechnic Institute, New York, May 7, 1968. ACMK has received many visitors from Many parts of the United States and from outside of the United States. There are currently 253 ACME Notes documenting the system. Our resuler mailing list includes 132 addresses in the Stanford community and 32 addresses outside. The PL/ACME user's manual has gone through two major revisions since August 1967; there are approximately 400 copies in use, Courses During the year, about 300 medical school Facuity, staff, residents, and Students attended the three-session ACME ccurse. About 50 percent of these now use ACME at least occasionally. u ie FR 0OS1L1L-02 SUMMARY OF RESOURCE USAGE The material for this section is present=i in two forms in che following = Oo pages. el he first presentation is ca zrintout as rescurce utilization is reporteé by ACME on a monthly besis. ct =ils presentation is then expanded to include tne coding needed for NIH tc rrelare its statistical report. As explained in Section I-A, all utiliescice- ed October, 1967. J n Hy oO by ct ry e period beginning Naar category? ACHE STZ Name Department c i F project BRELTBARD,G ACME ACME CLASS _,C_. ACME /ACME CROUSE, LL. ACME /CATH_ LAB CUMMINS, D ACME /DOMESTIC DREW ,D. ACME /STAT2I FEINBERG, DA ACME ACME FLEXER, R_ ACME /1TYV GILMAN, J ACME /ACME GERAROI,S. ACME /ACME HUNDLEY, LL ACME /ACHE IBM ENGINEERS ACHE /TERMDIAG KORTZEBORN,B ACME /DISASTER LIERE,R. ACME /ACHME MATOUS,J_ ACME /GET MEEK J. ACME /REST MILLER, JU. ACME /pie MILLER, J ACME /pie MOORE_,M_ ACME /stet NELSON,G_ ACHE /ACME OSBORNE,D ACM {TECH PATEL A. ACHE /ACME PLASCH, G_ ACM /ACME PUBLIC PROGRAMS ACME /ACME RIEMAN,J_ ACME /VAT SANDERS, WJ ACME /asdfg SANDERS,G ACME /CONSULT SCHACH, ©. ACHE /MEDCOMP SCHACH, E ACME /MEDCOMP SHIH» 1) ACME {STAT WIEDERHOLD,V ACME /Instruct WIEDERHOLD,G ACME /test WIEDERHOLD,G ACME /CSMpP WIEDERHOLD, V ACKME /CLASS WEEDERHOLD,G ACKE /demo WIEDERHOLD, V_ ACME total =" hours ' ,s 1160.62 22! /Manual averages per user O Gb: PAUSE AT LINE 26.800 RUN! ? runs 146 256 137 203 50 50 95 63 103 bh 64 9 286 15 8 190 3 95 23 26 3186 pagehours 13 Crant Mo. Section I~ minutes 3268 Subd 537? BSS h 15 2329 223 L, 152 1960 2114 129 3606 470 1355 L&99 97 O17 184% 395 big S443 654 18kh 7016 2401 LO 7281 159 LO 5647 59 1638 296 u3e 69637 pbageminut 20604 13088 59652 25572 60 S119 1063 13 5488 9080 878i 82 25134 1547 543 5500 574 54399 h3010 1380 1384 13178 2708 8343 2157 15702 149 2066 655 136 26777 205 5699 1033 1560 426310 = 7105.16 ; 290 . 1776 kh OOD. L- Oe es PHD AML TIL OLA MLA DNDN PY 4A LD AY LD OD OD OF DD KA OD $ s ~ Equiv 1030, To fh bt 2982, J16é,. 5. LOS 53. Q, 269, Loh, h3s, 2h, 1256, 76, 227, 275, 1é, 1719, 2150, 69, 69 658 135, h17, 2106, 685, 7. 2103, 32, 6, 1338 10 284 51. 78, 21315 88 \o - cost 15 20 60 60 00 295 15 65 LO oa 05 10 70 &5 15 00 70 95 50 00 20 90 Ld 15 85 16 LS 50 75 &0 285 225 .95 65 00 81 category#?7 MEDICAL SCHOOL? Name Departrmene project ADLER, S_. GENETICS /SE TAL ARORON 7L PHARMACOLOGY LCELL BARLOW, FH PATHOLOGY /EMISSTON BASSET. RL GENETICS /CENSUS BASSET,RL GENETICS /CEHSUS Aa ies ANESTHESIA / SHUNT BAYLEY, BIOCHEMISTRY / FLU BEATRICE, TES PATHOLOGY / LASER BEERNINK, KD FLEISCHMANN /HANNA BELLVILLE, E ANESTHESIA FOROBAD TE BELLVILLE,E ANESTHESIA /PROBABI BELLVILLE,E. ANESTHESIA /PROB BODMER,W_ GENETICS /POPGEN BOLTON,G_ ANESTHESIA /SCOPE BOLTON,G_ ANESTHESIA /SCOPE BRAST_.N_ MED /CATALOG BRAST_,N_ PSYCHIATRY /RODENTS BRITT_,R_ NEUROLOGY /STARR BROWN _,BN MED /PROTEIN BROWN _,L_ PHARMACOLOGY /ASSAY BROWNE MEDICINE /MED_DATA BROWN, BN MED / PROTEIN BRODY_,B_. NEUROLOGY /FLYHIGH BUNNENBURG,E CHEMISTRY /CHEM BUTLER, E__ UROLOGY /UROLOGY CANH_.,H.. PEDIATRICS /GQUAT CASTELANO,R_. RADIOLOGY /SCHEDULE CAVE__,P_. ANESTHESIA /ventl COLLINS, «&_ BIOCHEMISTRY /ATCase CONSTANTINO,C UROLOGY /AD DOERING, CH PSYCHIATRY /1SORATIO DOERING,CH PSYCHIATRY /DESMOLAS DONG. ,E_ SURGERY /DATA DONG _,E._ SURGERY /MARG1 DONG ,&. SURGERY /heart DUFFIE,A_ CHEMISTRY /CHE} DURBRIDGE,T PATHOLOGY /DEADMAN EDWARD,D_. PSYCHIATRY /STRESS ENGLUND, P_ ANESTHESIA /ENZYME ENLANDER,D PATHOLOGY /cases FJELDBO,W UROLOGY /CHEM FOLK ,B_ BIOCHEMISTRY /GRS FORREST,W VA /ANALGESI GERSCH,W_ NEUROLOGY /SYNTHES!I GLEASON,C NEUROLOGY /CORTMEAS GODWIN,D. RADIOLOGY /ADRENAL GOLDSTEIN,A PHARMACOLOGY /PHAT GOLDSTEIN, DB PHARMACOLOGY /BARB GOLDSTEIN,A PHARMACOLOGY /APH HAHM.,G_ RADIOLOGY /RADIATE HAKCE, AU PHARMACOLOGY MENOTAUR HARRIS,DU PEDIATRICS /EPIGENET runs 9 55 51 Lah 7 13 $9 107 2u Li 77 28 137 25 22 32 288 109 42 10 62 54 25 199 257 25 96 14 120 134 3354 140 24 27 89 12 22 204 L5 31 48 195 6k 19 26 33 11 Grant io. Bh section T-B minutes 15 1207 1197 3059 51 155 LhEO 2567 18h 530 95% 525 5699 287 250 1141 905% 361 1975 56 1405 1 2074 961 6242 16242 128 610 3675 5 243 4263 - 287 6963 14213 37 3017 252 966 388.8 87 920 8642 922 1048 2293 6°65 1657 296 g68 59h 305 pagem PR OOBLL-V0 inutes Equiv. cose &9O $s 2.45 6430 § 321.56 5870 §$ 293,506 50019 $ 1560,95 177 S$ 6,65 724 § 36.20 59h9 Ss 297,45 15875 § 693,75 612 $ 50.60 166) § 63,05 343] $ 171.55 2570 §$ 118.50 31552 § 1577.60 993 $ 49.65 1077 $ 53.85 6550 $ 327,50 66618 §$ 5330.70 31086 §$ 1558 .30 16315 $ 805.75 16h $ 8.20 8516 §$ 25,80 hes 0.20 7619 $ 380.95 7265 $ 363.25 39779 $ 1988,95 T44U9S5 § 729.75 Libs $ 57.30 2412 $ 120.60 32670 $ 1635.50 17 $ 0,85 888 § bb h0 20648 § 1052.80 10035 § 50.15 95314 $ 8765.70 109840 § 5492.06 126 $ 6.30 17393 $ 869.65 878 S$ 3.90 3865 § 193.25 142359 § 711.95 381 5 19,05 L642 § 232,10 77645 § 3882.25 10486 § 52% ,30 5122 $ 256.10 23462 §$ 1175.20 35958 $§ 21°6,90 913 § BEG 70 1241 8 60,55 L796 § 239,99 2322 $ 116.20 951 § L755 Name Department project HAUSAMEN,T MEDICINES /STAT HELLERSTEIN,D_ GENETICS /ELECTRO'I HERZENBERG, LL GENETICS /P1GGY HERZENBERG, LE GENETICS /LAS HILL UC BEOCHEMISTRY /MISSENS! HILFE OG FL VA Le! ACKSOR HUFF urd GENEVICS PREPRINT HY ANG. aU. GENETICS /GENLIBI HWANG ,J_ GENETICS THK IRSCH HWANG /J GENETICS /CROUT JONES DL BIOCHEMISTRY /FLU KADIS_,LL. ANESTHESIA / INDIRECT KAKTHANA,R_. PSYCHIATR JANOVAL KAPLAN, BL) PSYCHIATRY /PSYCHOPH KAPLAN, HP NUCLEAR /BLDVOL] KESSLER, § KOUNTZ,S__ KRAEMER, H PSYCHIATRY /MATSPEED SURGERY /TRANSPLA PSYCHIATRY /PSYSTAT KRISS _,J__ NUCLEAR /ASSAY KRISS _,J_ NUCLEAR /ASSAY LEDERBERG, J Generics / TESTS LEDERBERG, J_. GENETICS /MEMOPAD LEDERBERG, J” GENETICS /DENDRAL LEFBOWITZ,U PHARMCOLOGY /M LIEBES,S_ GENETICS /MS LUETSCHER, J MEDICINE /Blood LUMB__,Jd_ MICROBIOLGGY /C_TUM LUTZKER,M_ RADIO /TORY MACPHERSON,L = /META MAFELY,R. MEDICINE /€02 MCPHIE,P_. BIOCHEMISTRY MESEL_,E_ PEDIATRICS MESEL_,E_ PEDIATRICS MESEL_,E_ PEDIATRICS MESEL_,E_ PEDIATRICS E S Pr ORS / RNASE /DOGLAB /VSD /WER /TV MESEL_,E_ PEDIATIRICS /carcat MEYER_,S. MED /DOSE1 MILLER,R_ BIOCHEMISTRY MISC.USERS (no files) # MORRIS,M_ GENETICS MESC MORRIS,S_ GENETICS /EXPTE NALL tn DERMATOLOGY /PSORIASI NELSEN,T_ SURGERY /GASTRIC NYE ,W_ MICROBIOLOGY /STRUCTUR NYE Wi MED /STUDENT PEARSON, M BICCHEMISTRY PETRALLI,J INFECTIOUS PORTER, Ru BIOCHEMISTRY PRYOR HL MED {GROWTH RAB KINRD GeneTICS /SET REAM an ZAK NED /é REYNOLDS, WE GE /BIOSTAT ACM /SCRA /CTCOR /MED DATA /ATCKIM OY One a 1c C iN EVE TICS )o Al 07 “ ™ rp Ti] Chi Ti ne 5 runs }- Mm MD ROM VU ne UT ID WROD RO NOR! ue Ow ote 19¢@ 135 it 10 wm Oo 52 19 53 Lu 10.8 18 51 hg 12 185 28 li 164 347 17 37 32 52 17 90 53 113 6 318 12 L6 1272 162 &3 5 33 150 28 6 78 1295 15 12 70 87 Pos: . CNA . Grebo ie abl AAT Dw eee Section T-* mMiNates S65 S155 § 248% 21250 5 212] 12655 § 49% Vh79 $ 1549 57719 $ LONG b765 § 267 865 $ 3267 20079 § 234 820 § LS76 57849 §$ 7056 57050 § 23581 1iso0 $s 991; SU5h $ 383 1329 $ 591 3206 § 2437 1102 § 2750 1h106 § L425 1528 § 565 2476 $ 811 U533 $ 358 1240 $ 575] 1972 $ 1006 b317 S$ 228 1377 $ 6 2h 55760 $ 7650 b1555 § 149 510 § 1542 7598 $ 721 3105 § 2143? Vh700 $ 315 1164 § 3665 27923 $ hiv u5523 $ 7132 LO504 §$ 37 137 $ 13559 186106 §$ 142 641 § 1910 10657 §$ 27429 102039 § 3010 9968 § 2619 123574 $ 117 439 § 528 1722 § 6413 31529 § 930 4013 $ 73 252 § 7332 L3922 § 6612 $8012 § 425 1660 § 59 177 §s 1280 7556 § L123 23650 § pagaimtinutes Equiv. 157. 1062 632. DO AN ROR WO NI 2 An Ns, 1003, Ld 1892, 2857, 500, 157, 66, 160, 55 705, 76, 125, 226, 62, 2098, 215, 68, 2708, 2076, 25, 379, 155, 735, 5&, 1396, 2276, 2675, 6, 9305, 32, 532, 5101, hoe, 618, 21. 86, 1576, 200, 12, 2196, 1900 73. é. 377. 1162, Ll u n COS: 75 229 75 295 r. «95 ao 225 25 95 00 tO 50 00 70 5 50 10 50 LQ 80 65 00 60 65 85 00 75 50 90 25 60 20 15 15 20 85 29 05 85 95 0 70 95 10 LS 65 60 10 2590 00 65 30 50 Grant J 2h OO5L1-Ce sec Lion ae Name Department project runs minutes pageminutes Equiv. cost ROSS R CHEMISTRY /CHEM 7 2 5 8 0,25 ROSENTHAL, W. AUDIOLOGY /RESEARCH hil 662 2329 § 116.65 ROSAN_,R_. PATHOLOGY /OXYCEL Lb L835 2196 § 109,80 ROTH___,WL. PSYCHIATRY /COMP 63 1Gi3 BLOGS § 324,75 SAUNDERS, AM PATHOLOGY /MASTCELL 194 6162 25456 $ 1272.80 SCHNEIDERNAN, L MEDICINE /PATCHART 13 1h6 521 5S 26.05 SCUDO_,F._. GENETICS /MIGRA 27 2117 14655 § 732.75 SHEFFLER, TE BIOCHEMISTRY /OLIGOMER Lg 1593 8420 § £21.00 SUELVERMAN,L PATHOLOGY /QUEM 53 1792 7281 =5 364 05 SILVERS|A_ LIPID /PAT_DATA 31h &798 41522 $ 2076.10 SMALLWOOD,R MEDICAL /MEDIPLAN Lok 9O15 1018649 § 5092 45 STARK__,L_ PEYSIOLOGY /COMPUP 14 103 BuL7 $ 17.35 STENSON,B CARDIOLOGY /CATH_.LAB 302 VH217 233455 $ 11672.6h STILLMAN,R PHYCHOLOGY /PSYGAME 61 1683 6541 $ 327.05 STRICK,R_ MEDICINE /GASTRIC 81 1485 5969 $ 298.45 STRYER,L_ BIOCHEMISTRY /NANOS 20 471 2957 $ 147.85 STUEDEMAN,D GENETICS /ADMIN 34 1231 5264 § 263.20 THATHACHARI, YT DERMATOLOGY /DOPA 52 1130 60h § 230.20 TUCKER,RB GENETICS /MS 92 3009 Lhhug § 722.45 UPSHER,M_ UROLOGY /DOCALL 7 2h 125 § 6.25 VONDER,J_. ANESTHESIA /chuckl Lt 88 32h $ 16.20 VONDER, J. ANESTHESIA /johni 72 2412 20672 § 1633.69 VONDER,J_ ANESTHESIA /larryl 235 95353 79932 § 3996.60 VONDER, J ANESTHESIA /cardio 11 42 133 8 6.65 WARRICK,G V /STEROID 26 Log 1604 § 80,15 WEISSMAN, | RADIOLOGY /THYMUS 18 246 9Oh6 $ 47,30 WHITCHER,C GENETICS /spetrrn 10 23 107 § 5.35 WONG ,F_. RADIOLOGY /PLAN 63 1782 17651 § 882.55 ZAJAC_,F_. NEUROLOGY /FLYHIGH li 183 632 § 31,60 total 10512 345592 2504269 $ 125211.56 =" hours ' ,s 5759.86 -=' pagehours ' ,= 41737.8 ; averages per user 79 2598 18829 § OL1 44 © 14k: PAUSE AT LINE 26.800 RUN! ?G ?logoff! USER G _Miederhold_ ss, PROUECT test FROM aZbQ (LINE 5) TIME ON WAS 21:03, TIME OFF IS 21:50, 506 PAGESMINUTES WERE USE LOGOFF COMPLETED ON 4/27/68 category=?' OTHER MEDICAL USERS! Name Department project runs minutes pageminutes HARDYCK,C PSYCH /EMG 20 2 UNIVERSITY 0: CALIFORNIA, BERKELEY wy 109 27262 $ total 30 2509 27262 S =' hours |! J h8.4833 ,58!' pagehours ' ,» bSE 366 ; averages per user 0 12 113° $ O Jhb: PAUSE AT LINE 26.800 RUN! ? Faulv. cost 1563.10 J 5 An 63.10 5.68 category= Name “CAMPUS USERS! Department project runs BERNS_, RI CAMPUS /ASLIBERN 13 HARBAUGH, JW GEOLOGY Gic ouneoL 75 JUROW, J. SLA /ASOLPREL 275 LEPPERT,G MECHANICAL /ASOSLAS Lh LIKENESS, B AERO /ASGSAERO Ah a howe AERO /ASIS5 Zi RABINGWITZ,ML SLAC /ASOLPHEL 16 total bis =" hours ' ,5 238.850 2=! pagehours averages per user 1 @ Jbh: PAUSE AT LINE 26,800 RUN! ? category=#?' STANFORD COMPUTATION CENTER! Name Department project runs LIEBERMAN, M__ CAMPUS /TOSEAMRE 7 MOSES ,L_ STATISTICS /DEVELOPE 171 total 178 =' hours ' ,s# 90.2533 ,=' pagehours averages per user 0 © 144: PAUSE AT LINE 26,800 RUN! ? Graivs ie. section T-5 minutes paseminutes Equiv. cost: 241; Lhe7 § 74,35 5355 hEO1G § 2250.50 7556 SUSE2 §$ 171&.10 b3& 1660 $ 9% 00 202 1769 § 69,85 685 5558 § 177.90 65 212 $ 10,60 Lo331 68278 § Ub13.89 oF 1h71.30 7 59 367 $ minutes pageminutes Equiv. cost hy 12 5s 0,60 5410 32730 $ 1636,50 Shab 32742 $ 1637.10 ,= 545.700 3 22 136 § 6.82 Lh OLSS SoTgeuesoysy *SOTJOUSS [T2SO pooltq e4tum ueumy "mM § Leupog QTSh *s8nip peqered 6rtth solsesTeuy pue sorqgeugseue Fo Apngs satqeqrqueny "a SOTTTATTEG QTSh ‘snap peyepTed 6nnn SoTsosTeuy pue sotqaeugseue fo Apnyas satQeatauend ‘a SOTTTATTEg StSt “SENAp pe 1eyTear jo 6nhn SOTSoOsTeuy pue sortgeyuysaue go ApNIS SATQBITQUENy ‘g “OTLTATTEG *‘asnow OT9E ABOTOTQOLO TE aud UT ZoAeT ptroudéy uo satdureg "ay SyuUTUreeg *dodsozqoeds votsstue eqordoiotm reset Osh? 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Reference Dr. Lederze letter to Dr. Waxman of February 29, 1968. The 2321 had LOOK Bytes of memory and each of the 23lls had 7K Bytes; and the replacement 2314 elek Bytes. This change has resulted in substantially improved per from the hardware configuration at the expense of data storage car A second IBM 2414, Direct Access Storage Device, has been budgeted Tor addition to the configuration in February, 1959. It would be desirable to install this device as early as possible but delivery will be delayed to keev within the budget ceiling established for the third year. Travel expenses have been somewhat higher than budgeted in the awardé for the 02 year and $4,000 is requested agein Tor 03 year. It is frequently more economical to search out information and advice from institutic: individuals who have experienced problems than to duplicate efforts. In the field of computing the months that separate problem solutions ena publication (if any) cannot be afforded. wy Ni Grant pio, FR OOo LLG. INDIVIDUAL USER od —_ \ oo © fo ry S CY DESCRIPTION INVES TIGAT GE, DEPARTI ANSTITUTION: Stanford Computation Center Stanford Medical School Breitbard, Gary ACME FIELD OF GNA ISAT ON PLE Computer Science Testing in ACME AMOUNT OF RESOURCE USAGE: ts— wd INVESTIGATOR: ———_—«|d DEPART! INSTITUT JN: Stanford Computation Center 7 Avram Goldstein Pharmacology 1 School FIELD OF iN VESTICATION various Ai LOUNT T OF RES SOURCE USAGE L519 PROJECT DESCRIPTION (Approximately 300 words} ACME is used for general laboratory computations of several kinds, primarily those in which exhaustive calculations are required following experiments of several days' duration. These uses are all in connection with project Biochemical Mechanisms in Drug Addiction, supported by NIMH. Statistical packages are also used routinely. Some of the studies concern drug-induced activity of mice, measured in photoelectric counter cages at successive drug injections. Other studies involve tissue distribution of radioactive levorphanol in the mouse. Yet other studies concern binding of radioactive levorphanol under various conditions to subcellular fractions of mouse brain homogenates. ACME is also used for miscellaneous purposes in connection with graduate student training; a number of student projects are handled on this same project account. Seat Abn qa yee Graal IO. Bh ' Sectior INDIVIDUAL US ECT DESCRIPTION INVESTIGATOR. INSTITUTION: Stanford Computation Center Leonard Ae Herzenbers. Gevetics otenford Medical Center oar ne neern ars Stee tee deenemin rte em wine ota nen mine tnnnso ttebagn ane nae een toe FIELD OF ENVESTISC DAY ON PROJEC TELE: Genetics and Imnunology "precy" AMOUNT QF RESOURCE USAGE: 12,655 PROJECT DESCRIPTION (Approximately 300 words} Our laboratory is engaged in quantitative studies on immunoglobulins in antibody in production/mice., ACME has been used to calculate immunoglobulin levels from raw data obtained in experiments, to predict immuncglobulin levels from theoretical curves, to calculate geometric means for autibody assays and operations to convert raw data to useable experimental results. In addition some work hes already beczun to use ACHE to keep track of individual histories of thousands of mice maintained in this laboratory. The program to draw pedigree charts for all of the inbred strains is already in operation. Other programs to study the immmologic history are in process of preparation. It is hoped that programs will be developed to make information retrieval for antisera testing easier and quicker. C7 INDIVIDUAL USER PROSECT DESCRIPTION “INS1 V1 f UTIOH Stanford Comoutation Center t B ‘ antoed Maedteal Seheas” J. Hwang CEMET ERS Stvanroed Moaical Se Te PROJECT TITLE: INVESTIGATOR: | DEPAR FIELD OF INVESTIGAT! Ne CROUT GENETICS AMOUNT OF R ESOURCE USAGE: Ww NI . laa) Oo ay PRQJECT DESCRIPTION (Approximately 300 words) This project consists mainly of programs for the analysis of cyclic graphs to allow the enumeration of the rings structures of chemistry. Proerams analized the trivalent cyclic graphs, The main objectives are to Indicate all the possible sraphs, isomorphisms of superficially different graphs, symmetries within a praph, rational description of eack item, rational ordering of the graphs, rational numbering of the vertices and paths and compact, computable notation for each feature, Fach graph is represented as a Hani lton Cireult projected n the boundary of a regular polygzon with | vertices, Oining these M vertices and M/2 chords, since each vertex is rivalent., The locations of these chords are specified hy /2 characters, ON Grent No, FR oOsli-op Section Hie B INDIVIDUAL USER PROJECT DESCRIPTION INSTITUTION: Stanford Computetion Center Stanford Medical School INVESTIGATOR: DEPART MER CERNE TICS Jd. Hwang FIELD OF INVESTIGATION: PROJECT TITLE: GENETICS GEMLIBT AMOUNT OF RESOURCE USAGE: 20,079 PROJECT DESCRIPTION (Approximately 300 words) This project contains the statistical and miscelleanous promrams use by the Genetics Bepartment. Statictical programs: feneral statistical analysis for tke calculations of sum, mean, standard deviation, the analysis of variance, chisauareand prohahility of chisquare distribution, correlation and repression analysis, the norinal distribution with the same mean and standard deviation for fitting a curve, Plotting programs: Plot har eranh in 100 positions, plot of percentage distrihution, plot by function scaled to the range of 9 to 100, plot of multivalued function allows the choice and supersition of several characters. Flas is inserted on the chart when underflow or overflow occured, Sorting programs: Sortins a vector in ascending order, sort array and alphabetical informations. Grant No, ECT PROJ ye q ZR 2 L US DUA vi Vt IND INVESTIGATOR: Computa Pord Stan en UONES IN FIELD O§ vl L.. v time 4 vf QUE “CF tr to = c Protein CE USAGE. RESOUR em i AMOUNT 0! 91 050 PROJECT DESCRIP TiO! - cimately 300 words) (Appro Ss ‘ 1 OwVve pave thy Na erati ee . -~7-t Ons bse. ¢ we i o> vat nstriae } i j rol] c f Da can - fy _ ys OO ke 1g SL GT ow wok aD OS BM oe Q Hw Cie nlm “1 4 oF Moa 2 oO a Ree whe 22 44 i i n ey cP] “0 me — aed —_ Hi , “ Ne - my Z trues ca eculs 70 Sections oe t Sra! ae Section Tle B INDIVIDUAL USER PROJECT DESCRIPTION INVESTIGATOR: DEPARTMENT. INSTEFUTION: STANT ORD : J. Lederberg CEMETICS ve FIELD QF INVESTIGATION. PROJECT TITLE: Genetics PEMOPAR AMOUNT OF {ESOQURCE USAGE: PROJECT DESCRIPTION (Approximately 300 wards) A program for information retrieval interfacing with the Sanders 7270 display. Programs work with multiple files. Files is created hy program and store on disk, Program is called in by 1?! 2741 terminal thru ACHE. After the com- pilation by ACME, the excution of the program is initiated on the terminal, all the communication to and from the computer is turned Over to Sanders 720 display via the display keyboard, Program features the option of working vith any files, also provides selection of the following actions - create new file, addition of records to the existine files, alter content of any record, delete or Insert records, listing any portion of the existine file and search for key words fn the file. After each selection ts processed user has option of rerunnine the program without recompiling, While execution is in progress, in addition of the information displayed on the scope, a list of options and selections is printed on the IBM 2741 terminal to keep track of what kas heen done during each run, Grant No. FR o0411-09 Section Ili-B INDIVIDUAL USER PROJECT DESCRIPTION INVESTIGATOR: DEPARTMENT: INSTITUTION: SIDNEY LIEBES, JR. GENETICS STANFORD MEDICAL SCHOOL, STANFORD COMPUTATION CATER FIELD OF INVESTIGATION: TITLE: MASS SPECTRAL DATA HANDLING MS (MASS SPECTOMETRY) AMOUNT OF RESOURCE USAGE: 555760 PROJECT DESCRIPTION (Approximately 300 words) The computer has been used to provide various gupport functions fer research in the area of mass spectral microanalysis of organic materials. The mass svectremeter is run in either of two different modes, The data derived while running in one of these modes is transmitted automatically to the ACME system for storage. The other mode requires operator participation in the transmission, The stored data is subjected to a varlety of interpretative manipulations. In one running mde the mass peak locations are quadratically related to the real running time parameter. Linearization of the mass peak displacetcnt has been performed with the aid of the computer thus simplifying the identification of individual peaks. A computer driven television unit has been used to facilitate the visual comparison of pairs of mass spectra. The unit incorporates a manual control that positions a spot on the screen, The coordinate of the spot location may be entered into the computer by activation of a switch. The basic display format for the program consists of a central area surrounded by a marginal pattern of zones. A wide selection of program decisions can be made in program execution by directing the spot to different zones. This flexibility enabler selection,for example, of the spectra (identified by {ile numbers) to be displayed for each spectrum; the normalization to be used in the peak height display; the identification of the mass numbers associated with various peaks, ete, INVESTIGATOR, GOP AMOUNT OF | INDIVIDUAL USER PROJECT DESCRIPTION | INSTITUTION: 0” Tiere, Raymond 0, ACIS, Stanford Comou Stanford Medicel School “ee iq] - Wi: Consulting User Program Consulting IkcGe USAGE: 25,13) PROJECT DESCRIPTION (Approxizrately 300 words) Consultant and programmer. Programs written so far include a scatter D2 e plotting routine which plots as many different sets of data as is desired on one graph using a different symbol for each plot; array size checking procedures for approximately 35 statistical subroutines to oO _ keep users from writing over the syste sample programs for ar ACME publication which introduces the new user to ACME, Or ao IIDU IND PLO oO | 1 T OF I i OUR AN RIP —_ 0 Tl Sc Ms QJECT DES PR (Approxima ely 306 words) i r u Oo QO Mm fa Uv .. L eye ety 7 ah 4 i tS O ae ~ eet SO u) ry ! a mi ue © @ tm i i ney abs aedon ¢ oa ‘ Ma t CiiGrs Ovi t yh electrol mt é WwW 4 Grart No. FR 0O511-02 Section 1H-B INDIVIDUAL USER PRQUECT DESCRIPTION INVESTIGATOR, unwcas STITUTION: . bantord Computation Centor P Roy H. Maffly, MD. Medicine Stanford Medicel Sehcol FIELD OF tNVESTIGAT.ON, PROG E Ion transport Relationship of Metabolism to Sodium | Transport AMOUNT OF RESOURCE USAGE: 14,700 PROJECT DESCRIPTION (Approximately 300 words) We are measuring simultaneously the rate of sodium transport and the rate of CO? production by the urinary bladder of the toad. Rate of sodium transport is measured as the short circuit current. Rate of COj production is measured as the rate of decrease in conductivity of a dilute NaOH solution as CO? is trapped. Outputs proportional to each measure are recorded on a dual channel Varian recorder. The computer is used to facilitate "continuous" (4 minute inter- val) comparison of the two variables, By means of the computer we calculate (1) rate of CO9 production from change in conducti- vity (mot a proportional factor); (2) ratio of short circuit current to rate of CO9 production a) at each 4 minute interval, b) as increments following change of rate by adding variables (hormones, substrates, drugs), expressed as absolute numbers and as percentage change. We can thus compare changes in metabolism to changes in sodium transport to see how they interrelate. In particular we are studying which changes first in different siuta- tions and the different ratios obtained in different situations. Grant No. pRoos.es Section TH}. 8 INDIVIDUAL USER PROJECT DESCRIPTION INVESTIGATOR: DEPARTMENT INSTITUTION: Stanford Comput Emmanuel Mesel, M.D, Pediatric Cardiology Stanford Medi FIELD OF INVESTIGATION PROJECT TIT Direct Measurement of Intracardiac VSD Blood Flow. AMOUNT OF RESOURCE USAGE. 15 52% PROJECT DESCRIPTION (Approximately 300 words) Project VSD is concerned with blood flow through ventricular septal defects (VSD) surgically produced in dogs. Two major sets of comparisons are made: the pattern of flow through the VSD is compared with the pattern of differentia pressure between the left and right ventricles and with the electrocardiogram (ecg); and flow measured by an electromagnetic flow probe (which we consider a primary standard) is compared with flow measured by other techniques used on people (Flick, dye dilution). During the experiment, VSD flow, left and right ventricular pressures, and the ecg are recorded on tape. The more interesting data are selected for A to D conversion and for computation of the differential pressure by program WORKHORSE, Program LISTING lists digitized data, which, when graphed, permits comparison of the pattern of flow with the pattern of differential pressure. As might be expected, we have found that these patterns are very similar even under varying conditions (eg, ectopic beats), with flow slightly delayed with respect to pressure. Program cathlog produces a file which summarizes all our VSD experiments. ~ Future effort will be directed towards the incorporation and use of programs developed in project carcat for pattern recognition of pressure and flow contours. , Section fi- B INDIVIDUAL USER PROJECT DESCRIPTICN INVESTIGATOR. DEPARTMENT INSTITUTION. Emmanuel Mesel Pediatrics Stanford Medical School oy] { ay ae Ae Tord Comtutat FIELD OF HIVESTICATION PROLECT Medical Diagnosis WER AMOUNT OF RESOURCE USAGE. 49,504 PROJECT DESCRIPTION (Approximately 300 words) The project is an investigation of mathematical modeling techniques applicable to medical diagrams. The plan is ultimately to apply the cause- effect modeling techniques developed in reference 1 in an environment that allows online interaction between physician and computer model. Currently programmed is the congenital heart disease model of Warner . a : * and his collaborators“. Also programmed are text editor routines that are being used to speed the preparation of reference 1. Though a program has been written to implement the cause-effect modeling techniques of reference 1 using a Burroughs B5500 computer, adapting even that program to ACME will require considerable effect as the program depends heavily on the nearly unique ability of the B5500 to efficiently handle re- cursion and treat overlay automatically. It is felt that the ability to experiment with the models constructed in a way available only in an online system and that the increased interest and criticism that will result from testing the models produced in a clinical environment justify the effort, l. W.F. Rousseau, A Method for Computing Probabilities in Complex Situations, Doctoral Dissertation, Stanford University (in pteparation). 2. H.R. Warner, A.F. Toronto, L.G, Veasy, R. Stephenson, "A Mathematical Approach to Medical Diagnosis," JAMA , Vol. 177, July 22, 1961, pp 177-183. Grant Ho. pp. OOBL1OG. Section Hl-B INVESTIGATO | DEPARTINT. NSTITUTION ; stant ord Medical Center Emmanuel Mesel, 1D, Pediatrics pe bamzors Camput on Center FIELD OF | { INVE Sj IGA TION ! PROJGCT TITLE: On-line analysis of cardiac catheterize- Carcat tion data. AMOUNT OF RESOURCE USAGE. 186, 106 PROJECT DESCRIPTION (Appfoximately 300 words) Project "'carcat!' analyzes cardiac catheterization pressure tracings in children. From catheters in the right and left heart, pressure tracings are transmitted to the ACME computer, converted to digital data, and analyzed to determine atrial, ventricular, arterial, venous and wedge pressures. Currently the values in millimeter of mercury are calculated for the a and u waves, X and y troughs, and mean pressures in the artia and great veins, for systolic and end-diastolic pressures in the ventricles, for systolic, diastolic and mean pressures in the great arteries, and for mean pressures for the wedge positions. These values are calculated immediately and printed out on the computer terminal in the catheterization room. At this time, efforts are under way to improve and ascertain the accuracy of the algorithms used in pattern recognition for atrial and ventricular pressure tracings. The basic data acquisition and analysis system that has been set up will also be used to store data acquisition and analysis sytem that has been set up will also be used to store data for additional calculations and for the preparation of reports. As data is accumulated in storage from cardiac catheteriza- tions and from other sources of clinical information, it will be possible to analyze large amounts in clinical data rapidly using eh ACME computer. Research into methods of storing and recalling data for analysts ‘of clinical information will be an important part of our future efforts. INDIVIDUAL USER PROJECT DESC INVESTIGATOR INSTITUTION: S mol iitee : a Seonlev ld 7 Stan® ord Computati FIELD OF 5 NGATION PROJECT TITL EL - USAGE. 27,925 PROJECT DESCRIPTION “Approxivately 300 words) Gre WE fil O He G04 I i. ” OF INDIVIDUAL USER PROJECT DESCRIPTION INSTITUTION: . tn me ee ee ee te te cman a es INVESTIGATOR: DEPARTM 3 stanford Medics Stenford Compus NAT ay fact GENRE TCS GY Ville: PROS: BRAIN PROTHIN BIOCHEMISTRY AMOUNT OF RESOURCE USAGE: 123,7h PROJECT DESCRIPTION (Approximately 300 words) \ 2 An inexpensive, easy to realize interface for a Packard # 3514 liquid scintillation counter - IBM 1800 was built and tested. Several support pro- grams written in 1800 Assembly Tanguage end PI/1 comclete the interface. 1 (A full description is available in ACME Note #TPA-1). The interface makes possible direct reading of data into ACME deta files from the counter outout, linst 1 PUT SPAR hi ARG po INVES Wi OATO: fix: tye FIELD OF iN. see below AMOUN ’ OF RESOURS E USAGE 51529 Up ty CT DESCRIP 300 PROJE (Aporoxin ate! HON words) The usage of this terminal under this name actually represents usage by several investigators in this department. Mr. Nye has written most of the programs and his field of usege has been calculation of equilibrium constants of antibody-hapten reactions and structural studies. Dr. Rosenberg has used it for genetic studies of complement in mice. Dr. Stocker has used it fo genetic studies in bacteria, and Dr. Awkraut for statistical studies of the immunologicbulins in man. It has also been used in a vedagosic sense by students of these men as well as for manuscript editin antages of time sharing and data files becoms more evident, and ai sted instrumentation becotrs more commonplace, it is expected that there will be yn considerably more usage by this department. CO INDIVIDUAL USER PROJECT DESCRIPTIO WES: es —— RA ANS THTUTION: Dr. Petralii | Tnfectious Diseases F IL 0 0. Aye STiCAT- GH: i? Pep ie Med-Data pace nee eee Ae ree ee es ee ee ns . ee ene rental on omen eee ce ene mat cence ee nem ob een Ae mene ne nea AMOUNT OF SOU RCE USAGE: 43, Gee PROJECT DESCRIP TIO? ty (Approxivately 300 word This project deals with the data collected in the Ho: store in a form suiteble Laboratory, quality control of the input as well as s for later analysis pital Bacterlolosy Ge 5 or o As conceived the project will proceed as follows: the secretaries will type the information at the terminal. Yhe data will be placed in a tempor: frou which it will be aualyeed for quslity vtuel, Deta moet consis Hh oat previous data will be questioned and perhaps the leboratory test repent deta will then be placed in a complete file end a sorted file, each of which may be used for later analysis. The temsorary file will be used to put out the daily laboratory reports. This step will inelude some calculations such as conversion of sensitivity zone size to "sensitive" or “resistant”. OEE Using the computer to put on daily reports allows the project to proceed without addition of personnel to type in information, The input time of the secretary will be less than the time usually required to type repoxts. The data analysis will give us informoticn about the sensitivitics of various bacteria to antibiotics, This information vill help us to decide which treatnent | to use in certain cases. We will also be able to detect significant changes in sensitivity as well as major trends. On YO Stant ay C Stantord iM Robert W. Porter LD OF UNVES TI SAT ON | ekOszar Fa Kinetics of Aspartate | ATC KIN Transcarbary tase | AMOUNT. OF RESOURCE. USAGE: 58,012 PROJECT BDESSRIFTION (Approxirate!ly 300 words) ATC_KIN contains six programs used for the study of the reaction catalyzed by the enzyme, aspartate transcarbamylase. Program LstSq simply calculates a least-squares linear fit and standard deviation. Program DataFit calculates initial rates of rcaction from experimental data. These data are time points and counts per minute of product at each time point. Initial rates are calculated by a least-squares linear fit; rates are taken from the fitted slopes, converted to molar values using a value for specific radio-activity, and also corrected for enzyme concentration, This program, like the others in Project ATC_KIN, has been written so that it can be operated easily by other workers in the research group without experience in using computers, Other programs are used to fit the various kinetic equations which describe the relation of initial rate to substrate concentration. Program HyperFit fits the simple hyperbolic equation, called the Michaelis-Menten equation, The curve fitting procedure is very crude. For the two constant parameters in this function, initial estimates are provided, with ranges to be tested for both, Ina first step, a coarse fit is obtained by testing all the combinations of the trial values for the two parameters, in coarse steps covering the two ranges. In succeeding steps, the operator provides new, smaller ranges to be tested, repeating this procedure until achieving a sufficiently defined pair of values. Next the data points are scanned for deviations from this fitted curve, and the point with the largest deviation may be rejected, at the option of the operator. If the point is rejected, the fitting process is repeated, giving new values of the two parameters for the best curve, Program DataFit 2 simply gives a least-squares linear fil for the linear equation obtained from the reciprocal form of the Michaelis-Menten equation, first calculating reciprocal values of the data ports, and also calculating the kinetic parameters from the fitted slope and intercept. Vhese values are then used as the initial estimates for use in Programm HyporFit, Program DataFit 1 fits the much more complicated equation which describes the kinetics of the two substrate reaction, or the similar equation for the kinetics in the presence of inhibitor. The cquation fitted is in the simpler reciprocal form, which predicts a family of straight lines having a common intersection, fhe programis designed to select the valucs for the coordinates of the common intersection point which gives the 1) sest value for the deviations of all the experimental points from their corresponding best lines. The fitting procedure is Similar to t.c crude trial-and-error method described for program HyperFit. It should be noted that this curve-fitting procedure requires the use of an on-line communication system. Finally, Progran: ATCase 1] is a manuscript in preparation for publication of these kinetic studies. Ay hy INVESTIGATOR, DEPART EN! INSTITUT! Walter He RS Yai FIELD or Computer i AMOUNT OF RESOURCE USAGE: 24,650 PROJECT DESCRIPTION (‘Approxirais!y 300 words} The "S007" project is a subset of the general work of the Instrumentation Re Laboratory, Cenetics Department, in the ficid of instrumentation research conceived to ansver the question, "What kind of automated beste blological instrusentation would be suitable for interplanetary probes of exobio forme?" Accusl acceso -s Of this laboratory have shed light area and have inmediate here and nov applications in conventional biological and medical research. An example is the computer-directed mass spactrenster implemented by this laboratory and reported in this labo oratory's Technical Report No. IRL 1062. A quadrupole mass spectrometer was uniquely controlled by a computer to achieve a high order of instrument efficiency. The "S007" account supports technical and enginesring development. Prograus to help in engineering design have been written and used. Two such prograns are "RCs" and “Dblfocus." The first of these exeuples vas a streightforverd electrical engineering circuit analysis aid and the second was an evaluation of the accuracy and conplexity of instrumentation n ded for a contemplated mass spectroncter purchase. Other "S007" files have experimental data uscful in the develepment of algorithirs to be used in the control or data ecauleition Be Tees TM a, " o seo les of tte taps modes of ACH. TRACE” and "PICKER" ere excmples of this types. This investicator's a ety 2, es «Leg ce ot + mi de ge compen dt in the tame-cheved instru.sn that ACH! is to develop. is the direct digital connection of the ACH compucors to laboratory dnstrwsents. All of this investisater' 2 se of ACHE S a aD has been eirectly peal. To this dste usage has been in obilicy to serve these direct ¥ instrumentation moods of this lsboratery, pelucorily in the field of ms mi os oF an 2 ere) spectrom2ters, Onee principal goal is the integration of en Associated Electronic Indus m A c 3 p> we ; te o a (AET) model MS-9 mass spectrometer date the ACHE data system, This work is being supported by NIB grant 5 ROL AM 64257-0907. ~ ON ail ic _ Br _ Section HH-B INDIVIDUAL USER PROIECT DESCRIPTION INVESTIGATOR. EPART INSTH Uy ION ‘; A.M, SAUNDERS MoD PATTOTORY stanford Medical School —s : _ ves Stanford Comoutation Contes RIEL ') oF SVEN ETAT IVE CYTOLOGY MAST CHUL YES as AMOUNT Tndividual of 1O00-420C computer. microscope and two are The computer RESOURCE E : 25,456 (Approxirral objects, cells or standard spheres, Ox in a microscope for size and flourescence intensity at a spec wave length. are measured at a meee aoe - ied Data thus tabulated forms the basis for statistical analysis by The computer is used similarly in calculating corrections when the a is used as a spectroflourimeter. Two manuscripts have been accepted in preparation using these facilities. 7 S M Le Ube also used to write the text of the er ae INVESTIGATOR: | DEPARTMENT INSTITUTION F. Me. Seudo Genetles Stanford he, otanrord FIELD OF USAGE: 1h, 655 PROJECT DESCRIPTION (Approximately 300 words) ine program tabulates the results of models for the genetical variability among populations in a linear array, with migration between edjacent colonies. Tne basic quantity is given by the symmetric recursion +E BCR. + +oF =O; Fain * Pap) + BPs * Fay)? Wg = O35 its proper, special solution has vRePorn a. a = Ajay + Ajo where Ay > Ay are very complicated algebraic functions of the parameters. The final quantity is a linear combination of F 's, d up to a few hundred. Thus a d 2 ’ with the precision of this comouter, a too large error would result from its = 3 cay direct application. K ° 9